汤文军

男， 中科院上海有机化学研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

1991年至1995年 华东理工大学 学士
1995年至1998年 中国科学院上海有机化学研究所 硕士
1998年至2003年 美国宾夕法尼亚州立大学 博士
2003年至2005年 美国Scripps研究所 博士后
2005年至2009年 美国Boehringer Ingelheim Pharmaceuticals, Inc. 高级科学家
2009年至2011年 美国 Boehringer Ingelheim Pharmaceuticals, Inc. 首席科学家
2011年-至今 中国科学院上海有机化学研究所 研究员

研究领域和兴趣

手性膦配体、不对称催化、药物绿色制造

主要业绩

主要从事药物绿色合成与制造，包括发展手性膦配体、不对称催化反应、药物绿色合成以及天然产物全合成。目前已发展了百余个具有原创性结构的P-手性膦配体，不仅被广泛应用在相关学术研究，其中多个配体实现商品化生产，或以公斤级规模应用于药物研发中，有效促进数个高效和实用的不对称催化反应的研究，实现了系列具有重要生理活性天然产物和药物的高效合成，在新药研发和药物绿色制造中提供了高效的催化剂、合成方法和工艺路线。在国际著名化学期刊上发表论文一百二十余篇，申请国内及国际专利三十余项，授权知识产权二十余项，其中多项成功实现成果转化。
主持与参与国家自然科学基金项目、国家重点研发计划7项，省级科委合作项目与中科院专项3项；2015年获中国均相催化青年奖，2017年获国家自然科学基金委杰青资助，2018年获科技部中青年科技创新领军人才，2019年入选国家“万人计划”，同年获药明康德生命化学研究奖学者，2023年获中国科学院朱李月华优秀教师奖，2024年获英国皇家化学会Organic Division Horizon Prize。

代表成果

1. 论文
1. Wang, N.; Yang, H.;* Tang, W.* "Enantioselective Ruthenium-Catalyzed Hydrogenation of Substituted 3-Acylamino Pyridinium Salts". J. Am. Soc. Chem. 2025, in press.
2. Zhang, D.; Yang, H.;* Zhou Q.;* Tang, W.* Enantioselective synthesis of chiral 2,3-cis-disubstituted piperidines and C1-substituted tetrahydroisoquinolines by asymmetric Cu-catalyzed cyclizative aminoboration. Nat. Commun. 16 (2025), 6851.
3. Huang, J. (1st co-author); Pei, C. (1st co-author); Yang, H.;* Wu, B.;* Tang, W.* Enantioselective Palladium-Catalyzed α-Arylation of Acyclic Esters. Angew. Chem. Int. Ed., 64 (2025), e202505458.
4. Zhu, Y. (1st co-author); Zhang, Y. (1st co-author); He, D.; Yang, H.;* Xue, X.-S.;* Tang, W.* Rhodium-Catalyzed Asymmetric Reductive Hydroformylation of α-Substituted Enamides. J. Am. Chem. Soc., 146 (2024), 33249-33257.
5. Lin, Y.; Xu, G.;* Tang, W.* Chiral Polymeric Diamine Ligands for Iridium-Catalyzed Asymmetric Transfer Hydrogenation. J. Am. Chem. Soc., 146 (2024), 27736-27744.
6. Peng, H.(1st co-author); Zhao, D.(1st co-author); Tang, W.;* Peng, A.* Dienediamine: A Safe Herbicide as Paraquat Surrogate. Mol. Plant., 16 (2023), 1962-1975.
7. Yang, H.(1st co-author); Yu, H.(1st co-author); Stolarzewicz. I. A.;* Tang, W.* Enantioselective transformations in the synthesis of therapeutic agents. Chem. Rev., 123 (2023), 9397-9446.
8. Sun, J.; Chen, Y.; Ragab. S. S.; Gu, W.; Tang, Z.; Tang, Y.; Tang, W.* Total Syntheses of Polyhydroxylated Steroids by an Unsaturation-Functionalization Strategy. Angew. Chem., Int. Ed., 62(2023), e202303639.
9. Zhou, M.(1st co-author); Lin, Y.(1st co-author); Chen, X.-X.(1st co-author); Xu, G.;* Chung, L. W.;* Tang, W.* Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Reductive Coupling of Ketimines Templated by Chiral Diborons. Angew. Chem., Int. Ed., 62 (2023), e202300334.
10. Li, B.; Luo, B.; Yang, H.;* Tang, W.* Heck Reaction of N-Heteroaryl Halides for Concise Synthesis of Chiral α-Heteroaryl-substituted Heterocycles. Angew. Chem., Int. Ed., 61 (2022), e202209087.
11. Yang, H.; Tang, W.* Enantioselective Construction of ortho-Sulfur- or Nitrogen-Substituted Axially Chiral Biaryls and Asymmetric Synthesis of Isoplagiochin D. Nat. Commun., 13 (2022), 4577.
12. Wu, T.; Zhou, Q.; Tang, W.* Enantioselective α‐Carbonylative Arylation for Facile Construction of Chiral Spirocyclic β,β'‐Diketones. Angew. Chem., Int. Ed., 60 (2021), 9978-9983.
13. Tian, D,; Xu, R,; Zhu, J.; Huang, J.; Dong, W.; Claverie, J.; Tang, W.* Asymmetric Hydroesterification of Diarylmethyl Carbinols. Angew. Chem., Int. Ed., 60 (2021), 6305-6309.
14. Zhou, M.; Li, K.; Chen, D.; Xu, R.; Xu, G.* Tang, W.* Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron. J. Am. Chem. Soc., 142 (2020), 10337-10342.
15. Yang, H.; Sun, J.; Gu, W.; Tang, W.* Enantioselective Cross-Coupling for Axially Chiral Tetra-ortho-Substituted Biaryls and Asymmetric Synthesis of Gossypol. J. Am. Chem. Soc., 142 (2020), 8036–8043.
16. Mu, X.; Yu, H.; Peng, H.; Xiong, W.; Wu, T.; Tang, W.* Expedite Construction of Various Bridged Polycyclic Skeletons by Palladium-Catalyzed Dearomatization. Angew. Chem., Int. Ed., 59 (2020), 8143-8147.
17. Zhu, J.; Huang, L.; Dong, W.; Li, N.; Yu, X.; Deng, W.*; Tang,W.* Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin. Angew. Chem., Int. Ed., 58 (2019), 16119-16123.
18. Li, C.(1st co-author); Wan, F.(1st co-author); Chen, Y.; Peng, H.; Tang, W.*; Yu, S.*; McWilliams, J. C.*, Mustakis, J.; Samp, L.; Maguire, R. J. Stereoelectronic Effects in Ligand Design: Enantioselective RhodiumCatalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of (R)-Tofacitinib. Angew. Chem., Int. Ed., 58 (2019), 13573-13583.
19. Li, B.; Li, T.; Aliyu, M. A.; Li, Z.; Tang, W.* Enantioselective Palladium-Catalyzed Cross-Coupling of a-Bromo Carboxamides and Aryl Boronic Acids. Angew. Chem., Int. Ed., 58 (2019), 11355-11359.
20. Rao, X(1st co-author).; Li, N(1st co-author).; Bai, H(1st co-author).; Wang, Z.; Tang, W.* Efficient Synthesis of (-)-Corynoline by Sterically Hindered Enantioselective Palladium-Catalyzed α-Arylation. Angew. Chem., Int. Ed., 55 (2018), 5044–5048.
21. Tian, D(1st co-author).; Li, C(1st co-author).; Gu, G.; Peng, P.; Zhang, X.;* Tang, W.* Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles: A Crucial CONH Effect. Angew. Chem., Int. Ed., 55 (2018), 5044–5048.
22. Chen, D.; Xu, G.; Zhou, Q.; Chung, L, -W.; Tang, W.* Practical and Asymmetric Reductive Coupling of Isoquinolines Templated by Chiral Diborons. J. Am. Chem. Soc., 139 (2017), 9767-9770.
23. Zhao, G(1st co-author).; Xu, G(1st co-author).; Qian, C.; Tang, W.* Efficient Enantioselective Syntheses of (+)-Dalesconol A and B. J. Am. Chem. Soc., 139 (2017), 6630-6636.
24. Li, C.; Zhang, Y.; Sun, Q.; Gu, T.; Peng, H.; Tang, W.* Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles. J. Am. Chem. Soc. 138 (2016), 10774-10777.
25. Hu, N.; Li, K.; Wang, Z.; Tang, W.* Synthesis of Chiral 1,4-Benzodioxanes and Chromans by Enantioselective Palladium-Catalyzed Alkene Aryloxyarylation Reactions. Angew. Chem., Int. Ed., 55 (2016), 5044–5048.
26. Huang, L.; Zhu, J.; Jiao, G.; Wang, Z.; Yu, X.; Deng, W.-P.;* Tang, W.* Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram. Angew. Chem., Int. Ed. 55 (2016), 4527–4531
27. Hu, N(1st co-author).; Zhao, G(1st co-author).; Zhang, Y.; Liu, X.; Li, G.; Tang, W*. Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective hydroboration of α-Arylnamides. J. Am. Chem. Soc. 137 (2015), 6746-6749.
28. Du, K.; Guo, P.; Chen, Y.; Cao, Z.; Wang, Z,; Tang, W*. Enantioselective Palladium-Catalyzed Dearomative Cyclization for Efficient Synthesis of Terpenes and Steroids. Angew. Chem., Int. Ed., 54 (2015), 3033-3037.
29. Li, C.; Chen, T.; Li, B.; Xiao, G.; Tang, W*. Efficient Syntheses of Sterically Hindered Acyclic Secondary Alkyl Arenes by Suzuki-Miyaura Cross-Couplings. Angew. Chem., Int. Ed., 54 (2015), 3792-3796.
30. Fu, W.; Nie, M.; Wang, A.; Tang, W*. Highly Enantioselective Nickel-Catalyzed Intramolecular Reductive Cyclization of Alkynones. Angew. Chem., Int. Ed., 54 (2015), 2520-2524.
31. Xu, G.; Fu, W.; Liu, G.; Senanayake, C. H.; Tang, W*. Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions. J. Am. Chem. Soc., 136 (2014), 570–573.
32. Liu, G.; Liu, X.; Cai, Z.; Jiao, G.; Xu, G.; Tang, W*. Design of Phosphorus Ligands with Deep Chiral Pockets: Practical Synthesis fo Chiral β-Arylamines by Asymmetric Hydrogenation. Angew. Chem., Int. Ed., 52 (2013), 4235-4238.
33. Tang, W.*; Wei, X.; Li, W.; White, A.; Patel, N. D.; Savoie, J.; Gao, J. J.' Rodriguez, S.; Qu, B.; Haddad, N.; Lu, B. Z.; Krishnamurthy, D.; Yee, N. K.; Senanayake, C.H. A General and Special Catalyst for Suzuki-Miyaura Coupling Processes. Angew. Chem., Int. Ed., 49 (2010), 5879-5883.
2. 专利
1. 中国科学院上海有机化学研究所,上海市第十人民医院;一种非联吡啶盐类除草剂及其制备方法和应用; 2022, 2022116743009; 2025, ZL2022116743009;
2. 绍兴赜军生物医药科技有限公司;阿片类衍生物、其中间体及其制备方法; 2021, 2021110272407; 2025, ZL2021110272407;
3. 中国科学院上海有机化学研究所;一种甘氨酸-亚磷酸二甲酯法合成草甘膦优化工艺及其膦谱原位核磁监测方法; 2022, 2022105581462; 2025, ZL2022105581462.
4. 国科大杭州高等研究院;一种二茂铁基联芳基手性单膦配体、制备方法及应用;2025, 2025101326232;2025, ZL2025101326232;
5. 绍兴赜军生物医药科技有限公司;羟考酮类化合物、其中间体及制备方法; 2020, 2020113898155; 2024, ZL2020113898155;
6. 中国科学院上海有机化学研究所;聚合膦配体、包含其的过渡金属络合物、其制备和应用; 2021, 2021101133000; 2023, ZL2021101133000;
7. 宁波赜军医药科技有限公司;膦配体及其制备方法和催化合成邻位四取代联芳烃的应用; 2019, 201910165339X; 2023, ZL201910165339X;
8. 中国科学院上海有机化学研究所;一种手性杂环化合物的制备方法; 2019, 2019108313350; 2023, ZL2019108313350;
9. 中国科学院上海有机化学研究所;手性1,2-二胺化合物及其合成方法; 2017, 2017103694268; 2022, ZL2017103694268;
10. 中国科学院上海有机化学研究所; 一种金属配合物、中间体、其制备方法及应用; 2018, 201811178107X; 2022, ZL201811178107X;
11. 中国科学院上海有机化学研究所;一种联硼酸二醇酯、其制备方法、其中间体及其应用; 2019, 2019100415619; 2022, ZL 2019100415619;
12. 中国科学院上海有机化学研究所;羟考酮类化合物及其中间体和制备方法; 2019, 201911157445X; 2022, ZL201911157445X;
13. 中国科学院上海有机化学研究所;一种棉酚、其衍生物的制备方法及其中间体; 2019, 2019103648038; 2022, ZL2019103648038;
14. 中国科学院上海有机化学研究所;一种三级胺类化合物和双膦配体、其中间体及制备方法; 2019, 2019108060126; 2022, ZL2019108060126;
15. 中国科学院上海有机化学研究所;双齿膦-膦氧配体及其中间体、制备方法和应用; 2019, 2019103637118; 2021, ZL2019103637118;
16. 中国科学院上海有机化学研究所;手性双膦配体、其制备方法、中间体及应用; 2018, 2018113202122; 2021, ZL2018113202122;
17. 中国科学院上海有机化学研究所;金属络合物、制备方法和应用及其中间体;2017, 2017106973855; 2020, ZL2017106973855;
18. 中国科学院上海有机化学研究所;苯并氮杂磷杂茂膦氧配体及含其络合物、制备方法和应用;2018, 2018110530093; 2020, ZL2018110530093;
19. 中国科学院上海有机化学研究所;一种联芳基双膦配体、其制备方法及应用; 2017, 201711147384X; 2020, ZL 201711147384X;
20. 中国科学院上海有机化学研究所;芳基醇类化合物及艾司西酞普兰合成方法;2016, 2016100563903; 2019, ZL2016100563903;
21. 中国科学院上海有机化学研究所;过渡金属络合物、手性α-氨基三级硼酸酯及其制备方法; 2015, 2015102069294; 2018, ZL2015102069294;
22. 中国科学院上海有机化学研究所, 江苏联化科技有限公司;一种取代的2，3‑二氢苯并[d][1,3]氧杂磷杂茂配体的制备方法; 2013, 2013105048267; 2017, ZL2013105048267;
23. 中国科学院上海有机化学研究所;手性膦配体以及包含该配体的金属催化剂和它们的应用; 2013, 2013100203711; 2015, ZL2013100203711;
3. 著作
1. Axially Chiral Compounds: Synthesis and Application. Wiley-VCH, 2021.
2. Chiral Ligands. Evolution of Ligands for Asymmetric Catalysis. CRC Press/Taylor and Francis Oxford, 2021.
3. Handbook of CH-Functionalization. Wiely-VCH, 2022.
4. Comprehensive Chirality 2nd Edition. Elsevier, 2023.
5. Li, K.; Tang, W. Air-stable P-chiral Phosphorus Ligands for Asymmetric Catalysis and Synthesis" of Full Book "The Strem Chemiker, 2019.

*以上信息由高级会员个人更新和维护。