李昂

男， 中国科学院上海有机化学研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

2000.09--2004.07 北京大学化学与分子工程学院化学专业本科学生
2004.07--2010.01 美国斯克里普斯研究所生物学博士研究生
2010.01--2010.09 新加坡化学与工程科学研究所博士后
2010.09--至今 中国科学院上海有机化学研究所研究员、课题组长
2019.09--至今 中国科学院上海有机化学研究所副所长
2025.01--至今 中国科学院上海有机化学研究所党委副书记

研究领域和兴趣

复杂天然产物的化学合成；天然产物的作用机制解析

主要业绩

天然产物合成对化学学科的发展和小分子药物的创制起到了重要推动作用，是国际上非常活跃的研究领域。李昂博士在此领域取得了具有国际影响力的成绩，系统地发展了针对拥挤环系的合成策略，完成了14类90多个天然产物的全合成，其中45个为首次合成。他的一项代表性工作是虎皮楠生物碱的全合成。这类分子在过去30多年里引起了国际全合成界的广泛关注和激烈竞争。他完成了该家族多个成员的集合式合成，其中含有11个环和19个手性中心的hybridaphniphylline B的合成代表了该领域继Heathcock杰出工作后的一项突破。他在五味子降三萜、二萜生物碱以及吲哚萜类和生物碱合成领域也有重要建树。基于这些学术成就，他获得了Tetrahedron Young Investigator Award for Organic Synthesis (2017年) 和 Thieme-IUPAC Prize (2020年)。

在天然产物合成领域，李昂博士形成了鲜明的学术风格。首先体现在对于复杂分子结构的深刻解读，善于利用几何对称性、拓扑相似性、生源关联性等天然产物结构中的隐含要素，提出具有启发性的合成思路，将全合成化繁为简；其次体现在对于特定核心结构的创新性合成策略，例如打破分步修饰苯环的常规思路，发展电环化/芳构化策略，从头构建天然产物结构中的多取代苯环；最后体现在对于先进合成方法的发展和运用，一方面将碳氢键官能化等新反应融入复杂分子的构建之中，另一方面深入挖掘Prins环化等未被全合成界充分重视的古老反应的潜力，这样既提升了目标分子合成的效率，又丰富了上述合成方法的内容。他的研究工作对于天然产物化学结构和生源途径的解析以及基于活性天然产物的化学生物学研究和药物先导物创制也具有积极意义。

代表成果

1.L. Ren, Z. Lu, D. Wu, M. Ma, and A. Li,* Total synthesis of paxdaphnine A and daphlongamine B via an aza-prins cyclization strategy, J. Am. Chem. Soc. 2025, 147, 27137−27142.
2.J. Li, P. Ren, L. Wang, Y. Zhang, P. Yang,* W. He,* and A. Li,* Inverse-electron-demand Diels–Alder approach to densely substituted bicyclo[3.2.2]nonanes: Discovery of an autophagy regulator, Chin. Chem. Lett. DOI:10.1016/j.cclet.2025111381.
3.Y. Fei, B. Fan, Z. Liu, M. Ba, Z. Cui, P. Yang,* A. Li,* Concise total synthesis of ambiguine P. J. Am. Chem. Soc. 2025, 147, 18391−18396.
4.Y. Wu, S. Wang, Z. Guo, M. Sun, Z. Xu, Y. Du, F. Zhu, Y. Su, Z. Xu, Y. Xu, X. Gong, R. Fang, J. Hu, Y. Peng, Z. Ding, C. Liu, A. Li,* W. He,* Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperon-mediated autophagy, Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2400809121.
5.M. Ba, F. He, L. Ren, W. G. Whittingham, P. Yang, A. Li,* Scalable total synthesis of acremolactone B, Angew. Chem. Int. Ed. 2024, 63, e202314800.
6.Y. Peng, Y. Zhang, R. Fang, H. Jiang, G. Lan, Z. Xu, Y. Liu, Z. Nie, L. Ren, F. Wang, S.-D. Zhang, Y. Ma, P. Yang, H.-H. Ge, W.-D. Zhang,* C. Luo,* A. Li,* W. He,* Target identification and mechanistic characterization of indole terpenoid mimics: proper spindle microtubule assembly is essential for Cdh1-mediated proteolysis of CENP-A, Adv. Sci. 2024, 11, 2305593.
7.W. Zhang, M. Lu, L. Ren, X. Zhang, S. Liu, M. Ba, P. Yang, A. Li,* Total synthesis of four classes of Daphniphyllum alkaloids, J. Am. Chem. Soc. 2023, 145, 26569–26579.
8.B.-C. Yan, M. Zhou, J. Li, X.-N. Li, S.-J. He, J.-P. Zuo, H.-D. Sun, A. Li,* P.-T. Puno,* (–)-Isoscopariusin A, a naturally occurring immunosuppressive meroditerpenoid: structure elucidation and scalable chemical synthesis. Angew. Chem. Int. Ed. 2021, 60, 12859–12867.
9.P. Yang, J. Li, L. Sun, M. Yao, X. Zhang, W.-L. Xiao, J.-H. Wang, P. Tian,* H.-D. Sun,* P.-T. Puno,* A. Li,* Elucidation of the structure of pseudorubriflordilactone B by chemical synthesis. J. Am. Chem. Soc. 2020, 142, 13701–13708.
10.S. Zhou, K. Xia, X. Leng, A. Li,* Asymmetric total synthesis of arcutinidine, arcutinine, and arcutine. J. Am. Chem. Soc. 2019, 141, 13718–13723.
11.X. Zhang, B. N. Kakde, R. Guo, S. Yadav, Y. Gu, A. Li,* Total synthesis of echitamine, akuammiline, rhazicine, and pseudoakuammigine. Angew. Chem. Int. Ed. 2019, 58, 6053–6058.
12.Z. Lu, X. Zhang, Z. Guo, Y. Chen, T. Mu, A. Li,* Total synthesis of aplysiasecosterol A. J. Am. Chem. Soc. 2018, 140, 9211–9218.
13.S. Zhou, R. Guo, P. Yang, A. Li,* Total synthesis of septedine and 7-deoxyseptedine. J. Am. Chem. Soc. 2018, 140, 9025–9029.
14.W. Zhang, M. Ding, J. Li, Z. Guo, M. Lu, Y. Chen, L. Liu, Y.-H. Shen, A. Li,* Total synthesis of hybridaphniphylline B. J. Am. Chem. Soc. 2018, 140, 4227–4231.
15.Y. Chen, W. Zhang, L. Ren, J. Li, A. Li,* Total syntheses of daphenylline, daphnipaxianine A, and himalenine D. Angew. Chem. Int. Ed. 2018, 57, 952–956.
16.J. Li, W. Zhang, F. Zhang, Y. Chen, A. Li,* Total synthesis of daphniyunnine C (longeracinphyllin A). J. Am. Chem. Soc. 2017, 139, 14893‒14896.
17.Z. Zhang, J. Wang, J. Li, F. Yang, G. Liu, W. Tang, W. He, J.-J. Fu, Y.-H. Shen,* A. Li,* W.-D. Zhang,* Total synthesis and stereochemical assignment of delavatine A: Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution through Pd-catalyzed triflamide-directed C−H olefination. J. Am. Chem. Soc. 2017, 139, 5558–5567.
18.H. Li, Q. Chen, Z. Lu, A. Li,* Total syntheses of aflavazole and 14-hydroxyaflavinine. J. Am. Chem. Soc. 2016, 138, 15555–15558.
19.P. Yang, M. Yao, J. Li, Y. Li, A. Li,* Total synthesis of rubriflordilactone B. Angew. Chem. Int. Ed. 2016, 55, 6964–6968.
20.Y. Li, S. Zhu, J. Li, A. Li,* Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine. J. Am. Chem. Soc. 2016, 138, 3982–3985.
21.M. Yang, X. Yang, H. Sun, A. Li,* Total synthesis of ileabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole. Angew. Chem. Int. Ed. 2016, 55, 2851–2855.
22.Z. Lu, H. Li, M. Bian, A. Li,* Total synthesis of epoxyeujindole A. J. Am. Chem. Soc. 2015, 137, 13764–13767.
23.S. Zhou, H. Chen, Y. Luo, W. Zhang, A. Li,* Asymmetric total synthesis of mycoleptodiscin A. Angew. Chem. Int. Ed. 2015, 54, 6878–6882.
24.M. Yang, J. Li, A. Li,* Total synthesis of clostrubin. Nat. Commun. 2015, 6, 6445.
25.Z. Meng, H. Yu, L. Li, W. Tao, H. Chen, M. Wan, D. J. Edmonds, J. Zhong, A. Li,* Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families. Nat. Commun. 2015, 6, 6096.
26.J. Li, P. Yang, M. Yao, J. Deng, A. Li,* Total synthesis of rubriflordilactone A. J. Am. Chem. Soc. 2014, 136, 16477–16480.
27.Z. Lu, M. Yang, P. Chen, X. Xiong, A. Li,* Total synthesis of hapalindole-type natural products. Angew. Chem. Int. Ed. 2014, 53, 13840–13844.
28.Y. Sun, P. Chen, D. Zhang, M. Baunach, C. Hertweck, A. Li,* Bioinspired total synthesis of sespenine. Angew. Chem. Int. Ed. 2014, 53, 9012–9016.
29.J. Deng, S. Zhou, W. Zhang, J. Li, R. Li, A. Li,* Total synthesis of taiwaniadducts B, C, and D. J. Am. Chem. Soc. 2014, 136, 8185–8188.
30.Y. Sun, R. Li, W. Zhang, A. Li,* Total synthesis of indotertine A and drimentines A, F, and G. Angew. Chem. Int. Ed. 2013, 52, 9201–9204.
31.Z. Lu, Y. Li, J. Deng, A. Li,* Total synthesis of the Daphniphyllum alkaloid daphenylline. Nat. Chem. 2013, 5, 679–684.
32.M. Bian, Z. Wang, X. Xiong, Y. Sun, C. Matera, K. C. Nicolaou,* A. Li,* Total syntheses of anominine and tubingensin A. J. Am. Chem. Soc. 2012, 134, 8078–8081.
33.J. Deng, B. Zhu, Z. Lu, H. Yu, A. Li,* Total synthesis of (–)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart. J. Am. Chem. Soc. 2012, 134, 920–923.

*以上信息由高级会员个人更新和维护。