高级会员

欢迎 薛江丽 会员加入中国化学会
欢迎 陈宗兴 会员加入中国化学会
欢迎 王璐 会员加入中国化学会
欢迎 赵昌明 会员加入中国化学会
欢迎 罗然 会员加入中国化学会
欢迎 吴兵 会员加入中国化学会
欢迎 王静云 会员加入中国化学会
欢迎 田爽 会员加入中国化学会
欢迎 陆冰 会员加入中国化学会
欢迎 邓思琦 会员加入中国化学会
欢迎 王敏燕 会员加入中国化学会
欢迎 隋朝 会员加入中国化学会
欢迎 徐天赐 会员加入中国化学会
欢迎 岳浩宇 会员加入中国化学会
欢迎 张进涛 会员加入中国化学会
欢迎 邱慧莹 会员加入中国化学会
欢迎 宋世杰 会员加入中国化学会
欢迎 江雯惠 会员加入中国化学会
欢迎 金宇豪 会员加入中国化学会
欢迎 段征 会员加入中国化学会

咨询:haojiangtao@iccas.ac.cn

点击申请中国化学会会员

李昂

男, 中国科学院上海有机化学研究所, 教授/研究员/教授级高工或同等级别

学习/工作经历

工作经历:
2010– 中国科学院上海有机化学研究所,生命有机化学国家重点实验室,研究员
2010 新加坡化学与工程科学研究所,博士后,导师:K. C. Nicolaou 教授

教育背景:
2004–2009 美国斯克里普斯研究所,博士, 导师:K. C. Nicolaou 教授
2000–2004 北京大学化学与分子工程学院,理学学士, 导师:杨震教授

研究领域和兴趣

活性天然产物的化学合成

主要业绩

天然产物合成对化学学科的发展和小分子药物的创制起到了重要推动作用,是国际上非常活跃的研究领域。李昂博士在此领域取得了具有国际影响力的成绩,系统地发展了针对拥挤环系的合成策略,完成了14类90多个天然产物的全合成,其中45个为首次合成。他的一项代表性工作是虎皮楠生物碱的全合成。这类分子在过去30多年里引起了国际全合成界的广泛关注和激烈竞争。他完成了该家族多个成员的集合式合成,其中含有11个环和19个手性中心的hybridaphniphylline B的合成代表了该领域继Heathcock杰出工作后的一项突破。他在五味子降三萜、二萜生物碱以及吲哚萜类和生物碱合成领域也有重要建树。基于这些学术成就,他获得了Tetrahedron Young Investigator Award for Organic Synthesis (2017年) 和 Thieme-IUPAC Prize (2020年)。

在天然产物合成领域,李昂博士形成了鲜明的学术风格。首先体现在对于复杂分子结构的深刻解读,善于利用几何对称性、拓扑相似性、生源关联性等天然产物结构中的隐含要素,提出具有启发性的合成思路,将全合成化繁为简;其次体现在对于特定核心结构的创新性合成策略,例如打破分步修饰苯环的常规思路,发展电环化/芳构化策略,从头构建天然产物结构中的多取代苯环;最后体现在对于先进合成方法的发展和运用,一方面将碳氢键官能化等新反应融入复杂分子的构建之中,另一方面深入挖掘Prins环化等未被全合成界充分重视的古老反应的潜力,这样既提升了目标分子合成的效率,又丰富了上述合成方法的内容。他的研究工作对于天然产物化学结构和生源途径的解析以及基于活性天然产物的化学生物学研究和药物先导物创制也具有积极意义。

代表成果

1. 代表性论文:
1) P. Yang, J. Li, L. Sun, M. Yao, X. Zhang, W.-L. Xiao, J.-H. Wang, P. Tian,* H.-D. Sun,* P.-T. Puno,* A. Li,* Elucidation of the structure of pseudorubriflordilactone B by chemical synthesis. J. Am. Chem. Soc. 142 (2020), DOI: 10.1021/jacs.9b09699
2) S. Zhou, K. Xia, X. Leng, A. Li,* Asymmetric total synthesis of arcutinidine, arcutinine, and arcutine. J. Am. Chem. Soc. 141 (2019), DOI: 10.1021/jacs.9b05818
3) X. Zhang, B. N. Kakde, R. Guo, S. Yadav, Y. Gu, A. Li,* Total synthesis of echitamine, akuammiline, rhazicine, and pseudoakuammigine. Angew. Chem. Int. Ed. 58 (2019), DOI: 10.1002/anie.201901086
4) Z. Lu, X. Zhang, Z. Guo, Y. Chen, T. Mu, A. Li,* Total synthesis of aplysiasecosterol A. J. Am. Chem. Soc. 140 (2018), DOI: 10.1021/jacs.8b05070
5) S. Zhou, R. Guo, P. Yang, A. Li,* Total synthesis of septedine and 7-deoxyseptedine. J. Am. Chem. Soc. 140 (2018), DOI: 10.1021/jacs.8b03712
6) W. Zhang, M. Ding, J. Li, Z. Guo, M. Lu, Y. Chen, L. Liu, Y.-H. Shen, A. Li,* Total synthesis of hybridaphniphylline B. J. Am. Chem. Soc. 140 (2018), DOI: 10.1021/jacs.8b01681
7) Y. Chen, W. Zhang, L. Ren, J. Li, A. Li,* Total syntheses of daphenylline, daphnipaxianine A, and himalenine D. Angew. Chem. Int. Ed. 57(2018), DOI:10.1002/ange.201711482
8) J. Li, W. Zhang, F. Zhang, Y. Chen, A. Li,* Total synthesis of daphniyunnine C (longeracinphyllin A). J. Am. Chem. Soc. 139 (2017), DOI: 10.1021/jacs.7b09186
9) Z. Zhang, J. Wang, J. Li, F. Yang, G. Liu, W. Tang, W. He, J.-J. Fu, Y.-H. Shen,* A. Li,* W.-D. Zhang,* Total synthesis and stereochemical assignment of delavatine A: Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution through Pd-catalyzed triflamide-directed C−H olefination. J. Am. Chem. Soc. 139 (2017), DOI: 10.1021/jacs.7b01718
10) H. Li, Q. Chen, Z. Lu, A. Li,* Total syntheses of aflavazole and 14-hydroxyaflavinine. J. Am. Chem. Soc. 138 (2016), DOI: 10.1021/jacs.6b10880
11) P. Yang, M. Yao, J. Li, Y. Li, A. Li,* Total synthesis of rubriflordilactone B. Angew. Chem. Int. Ed. 55 (2016), DOI:10.1002/ange.201601915
12) Y. Li, S. Zhu, J. Li, A. Li,* Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine. J. Am. Chem. Soc. 138 (2016), DOI: 10.1021/jacs.6b00764
13) M. Yang, X. Yang, H. Sun, A. Li,* Total synthesis of ileabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole. Angew. Chem. Int. Ed. 55 (2016), DOI:10.1002/ange.201510568
14) Z. Lu, H. Li, M. Bian, A. Li,* Total synthesis of epoxyeujindole A. J. Am. Chem. Soc. 137 (2015), DOI: 10.1021/jacs.5b09198
15) S. Zhou, H. Chen, Y. Luo, W. Zhang, A. Li,* Asymmetric total synthesis of mycoleptodiscin A. Angew. Chem. Int. Ed. 54 (2015), DOI: 10.1002/ange.201501021
16) M. Yang, J. Li, A. Li,* Total synthesis of clostrubin. Nat. Commun. 6 (2015), DOI:10.1038/ncomms7445
17) Z. Meng, H. Yu, L. Li, W. Tao, H. Chen, M. Wan, D. J. Edmonds, J. Zhong, A. Li,* Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families. Nat. Commun. 6 (2015), DOI:10.1038/ncomms7096
18) J. Li, P. Yang, M. Yao, J. Deng, A. Li,* Total synthesis of rubriflordilactone A. J. Am. Chem. Soc. 136 (2014), DOI:10.1021/ja5092563
19) Z. Lu, M. Yang, P. Chen, X. Xiong, A. Li,* Total synthesis of hapalindole-type natural products. Angew. Chem. Int. Ed. 53 (2014), DOI: 10.1002/anie.201406626
20) Y. Sun, P. Chen, D. Zhang, M. Baunach, C. Hertweck, A. Li,* Bioinspired total synthesis of sespenine. Angew. Chem. Int. Ed. 53 (2014), DOI: 10.1002/anie.201404191
21) J. Deng, S. Zhou, W. Zhang, J. Li, R. Li, A. Li,* Total synthesis of taiwaniadducts B, C, and D. J. Am. Chem. Soc. 136 (2014), DOI:10.1021/ja503972p
22) Y. Sun, R. Li, W. Zhang, A. Li,* Total synthesis of indotertine A and drimentines A, F, and G. Angew. Chem. Int. Ed. 52 (2013), DOI: 10.1002/anie.201303334
23) Z. Lu, Y. Li, J. Deng, A. Li,* Total synthesis of the Daphniphyllum alkaloid daphenylline. Nat. Chem. 5 (2013), DOI: 10.1038/nchem.1694
24) M. Bian, Z. Wang, X. Xiong, Y. Sun, C. Matera, K. C. Nicolaou,* A. Li,* Total syntheses of anominine and tubingensin A. J. Am. Chem. Soc. 134 (2012), DOI:10.1021/ja302765m
25) J. Deng, B. Zhu, Z. Lu, H. Yu, A. Li,* Total synthesis of (–)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart. J. Am. Chem. Soc. 134 (2012), DOI:10.1021/ja211444m

2. 重要学术会议邀请报告:
1) New approaches to radical chemistry, 2020, 第十九届中美卡弗里前沿研讨会, 美国
2) Total Synthesis of Polycyclic Natural Products, 2019, 第54届比尔根斯托克会议, 瑞士
3) 多环生物碱的全合成, 2019, 第十一届全国有机化学学术会议, 上海
4) 多环天然产物的全合成, 2019, 天然有机 (药物)化学高峰论坛, 兰州
5) Total Synthesis of Polycyclic Natural Products,2019, 第二届韩国高等科学技术学院-BK21讲座奖研讨会,韩国
6) 芳香天然产物的全合成, 2019, 第一届创新药药物研究(暨绿色制药技术)国际高峰论坛, 杭州
7) 碳氢键官能团化在天然产物全合成中的策略应用, 2018, 江苏省产业技术研究院药物合成技术国际研讨会,南京
8) Total Synthesis of Polycyclic Natural Products, 2018, 第七届中泰双边天然产物化学与药物发现学术研讨会, 南京.
9) Total Synthesis of Polycyclic Natural Products, 2018, The 24th Conference on Isoprenoids, 波兰
10) Total Synthesis of Polycyclic Natural Products, 2018, Gordon Research Conference on Stereochemistry, 美国
11) Total Synthesis of Daphniphyllum Alkaloids, 2018, Organic & Biomolecular Chemistry Symposium, 上海
12) Total Synthesis of Polycyclic Natural Products, 2018, The 53rd Swiss Chemical Society Conference on Stereochemistry (Bürgenstock Conference), 瑞士
13) The Chemistry of Chirality, 2018, 第18届中美前沿科学研讨会预备会, 北京
14) Total Synthesis of Polycyclic Natural Products, 2017, Gordon Research Conference on Natural Products & Bioactive Compounds, 美国
15) Total Synthesis of Natural Products Containing Multisubstituted Arenes, 2017, The 25th International Symposium: Synthesis in Organic Chemistry, 英国
16) Total Synthesis of Polycyclic Natural Products, 2017, The 18th Tetrahedron Symposium, Award Lecture, 匈牙利
17) Total Synthesis of Natural Products Containing Multisubstituted Arenes, 2017, Manchester-Shanghai-Hong Kong Trilateral Symposium on Chemistry Frontiers, 上海
18) Prins Cyclization in Natural Product Synthesis, 2017, Organic/Green Chemistry Joint Symposium, The 97th Annual Meeting of The Chemical Society of Japan, 日本
19) Total Synthesis of Polycyclic Natural Products, 2017, China Novartis Institute of BioMedical Research Synthesis Symposium, 上海
20) Total Synthesis of Polycyclic Natural Products, 2017, Bristol-Myers Squibb Lecture, 美国
21) Prins Cyclization in Natural Product Synthesis, 2016, International Conference on New Challenges in Organic Synthesis, 广州
22) Total Synthesis of Natural Products Possessing Multisubstituted Arenes, 2016, The 26th Symposium on Optically Active Compounds, 日本
23) Constructing Multisubstituted Arenes of Natural Products, 2016, Tetrahedron Event: Challenges in Organic and Medicinal Chemistry, 北京
24) Total Synthesis of Natural Products Possessing Multisubstituted Arenes, 2016, The 6th China-Thailand Joint Workshop on Natural Products and Drug Discovery, 泰国
25) 含有多取代芳环的天然产物的全合成, 2016, 中国化学会第十一届全国天然有机化学学术会议, 上海
26) Late Stage Prins Cyclization in Natural Product Synthesis, 2016, 第十八届中国科协年会第一分会: 绿色化学, 西安
27) Prins Cyclization in Natural Product Synthesis, 2016, 第五届天然产物全合成青年学术研讨会, 昆明
28) Total Synthesis of Sespenine: a Bio-Inspired Aza-Prins Approach, 2016, The 12th Sino-US Chemistry Professor Conference, 广州
29) 天然产物全合成研究, 2015, 中国化学会2015年化学青年学术论坛, 福州
30) Synthesizing Multisubstituted Arenes of Natural Products, 2015, The 15th Tateshina Conference on Organic Chemistry, 日本
31) Assembling Multisubstituted Arenes of Natural Products, 2015, The 3rd Roche and RSC Chemistry Symposium on Leading Science for Drug Discovery, 上海
32) Total Synthesis of Indole Diterpenoids, 2015, The 12th National Synthetic Organic Chemistry Symposium, 桂林
33) Prins Cyclization in Natural Product Synthesis, 2015, NSFC-RSC International Symposium on Emerging Frontiers in Organic Synthesis, 上海
34) The Detours in Bioinspired Synthesis of Natural Products, 2015, 中国化学会第九届全国有机化学学术会议, 长春
35) Synthesis of Natural Products with Multisubstituted Arenes, 2015, The 2nd Element Organic Chemistry Symposium, 天津
36) The Development of Electrocyclization/Aromatization Strategies in Natural Product Synthesis, 2015, The 8th Sino-German Frontiers of Science Symposium, 德国
37) Total Synthesis of Indole Terpenoids, 2015, The 2nd Organic Chemistry Frontiers International Symposium, 杭州
38) Electrocyclization/Aromatization as a Powerful Strategy in Natural Product Synthesis, 2014, The 13th International Symposium for Chinese Organic Chemists, 厦门
39) Total Synthesis of Indole Terpenoids, 2014, The 11th National Synthetic Organic Chemistry Symposium, 第十一届全国有机合成会议, 上海
40) The 6π Electrocyclization in Natural Product Synthesis, 2014, The 2nd International Symposium on Natural Product Synthesis and Innovative Process Methods for Drug Manufacture, 南京
41) The Detours in Bioinspired Natural Product Synthesis, 2014, 第三届天然产物全合成-青年学术研讨会, 兰州
42) Total Synthesis of Sespenine: A Bio-Inspired Aza-Prins Approach, 2014, The 10th Sino-US Chemistry Professor Conference, 济南
43) Aza-Prins Cyclization in Natural Product Synthesis, 2013, The 3rd Junior International Conference on Cutting-Edge Organic Chemistry in Asia, 日本
44) Total Synthesis of Polycyclic Natural Products Using 6π Electrocyclization, 2013, 全国药物化学学术会议, 济南
45) 6π Electrocyclization for Synthesizing Natural Products, 2013, Roche and Royal Society of Chemistry Symposium, 上海
46) Bioinspired Aza-Prins Cyclization in Syntheses of Indole Natural Products, 2013, 中国化学会第八届全国有机化学学术会议, 重庆
47) Total Synthesis of the Daphniphyllum Alkaloid Daphenylline, 2013, 第八届全国化学生物学学术会议, 上海
48) To Travel and to Arrive: A Fascinating Journey of Natural Product Synthesis, 2013, 第二届天然产物全合成-青年学术研讨会, 北京
49) 6π Electrocyclization in Natural Product Synthesis, 2012, The 7th International Conference on Cutting-Edge Organic Chemistry in Asia, 新加坡
50) Total Synthesis of Daphenylline, 2012, New Horizons in Natural Product Synthesis Symposium, 英国
51) Total Synthesis of Daphenylline via 6π Electrocyclization, 2012, The 1st International Symposium on the Natural Product Synthesis and Process Methods for Drug Manufacture, 重庆
52) Total Synthesis of Fusarisetin A, 2012, The 4th Young Investigators Workshop of the Organic Division of EuChemS, 奥地利
53) Divergent Total Synthesis of Indole Terpenoids, 2012, The 8th Sino-US Chemistry Professor Conference, 昆明

*以上信息由高级会员个人更新和维护。