曹鸿志

男， 中国海洋大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2020.08-至今：中国海洋大学医药学院，教授
2010.01-2020.07：山东大学国家糖工程技术研究中心，副教授、教授
2005.12-2009.12：美国加州大学戴维斯分校化学系，博士后
2005.07-2005.12：上海美迪西生物医药有限公司，课题组长
2004.07-2005.06：中国科学院上海有机化学研究所，科研助理
2000.08-2004.06：中国科学院上海有机化学研究所，博士
1997.09-2000.06：郑州大学化学系，硕士
1993.09-1997.06：郑州大学化学系，本科

研究领域和兴趣

糖化学生物学、糖生物工程

主要业绩

曹鸿志，中国海洋大学“筑峰”二级岗特聘教授，博士生导师，万人计划科技创新领军人才(2022)，山东省泰山学者特聘专家(2022)。目前兼任国际糖科学专业杂志Carbohydr. Res.和J. Carbohydr. Chem.编委(2016-)，中国化学会糖化学专业委员会秘书长(2019-)，获惠永正糖科学奖—青年创新奖(2021)，日本水谷糖科学基金会（Mizutani Foundation for Glycoscience）的Research Grant Award (2020年)，中国化学会—巴斯夫公司青年知识创新奖(2019)，Taylor Francis出版社Tomoya Ogawa Young Investigator Award (2017年)，张树政糖科学奖—优秀青年奖(2015年)等。在Nat. Catal., JACS, Angew. Chem.等国际知名期刊发表SCI论文60余篇，主持科技部重点研发计划课题，国自然国际合作、面上等省部级以上项目10余项。其课题组主要从事复杂功能糖链的无细胞体生物合成、糖化学生物学和糖药物相关领域的研究。

代表成果

1. Jinfeng Ye, Hui Xia, Na Sun, Chang-Cheng Liu, Anran Sheng, Lianli Chi, Guofeng Gu, Shuqi Wang, Xian-Wei Liu, Jie
Zhao, Ping Wang, Min Xiao, Fengshan Wang, Hongzhi Cao*. Reprogramming the enzymatic assembly line for site
specific fucosylation. Nature Catal. 2019, 2, 514-522.
2. Na Lu, Jinfeng Ye, Jiansong Cheng, Aniruddha Sasmal, Chang-Cheng Liu, Wenlong Yao, Jun Yan, Naazneen Khan,
Wen Yi, Ajit Varki, Hongzhi Cao*. Redox-controlled site-specific α2,6-sialylation. J. Am. Chem. Soc. 2019, 141,
4547−4552.
3. Tian Gao, Jingyu Yan, Chang-Cheng Liu, Angelina S. Palma, Zhimou Guo, Min Xiao, Xi Chen, Xinmiao Liang,
Wengang Chai, Hongzhi Cao*. Chemoenzymatic synthesis of O-mannose glycans containing sulfated or nonsulfated
HNK-1 epitope. J. Am. Chem. Soc. 2019, 141, 19351-19359.
4. Xin Meng, Wenlong Yao, Jiansong Cheng, Xu Zhang, Lan Jin, Hai Yu, Xi Chen, Fengshan Wang*, Hongzhi Cao*.
Regioselective chemoenzymatic synthesis of ganglioside disialy tetrasaccharide epitopes. J. Am. Chem. Soc. 2014,
136(14), 5205-5208.
5. Chang-Cheng Liu, Jinfeng Ye, Hongzhi Cao*. Chemical evolution of enzyme-catalyzed glycosylation. Acc. Chem. Res.
2024, 57, 636-647.
6. Na Lu, Yun Li, Hui Xia, Kan Zhong, Chenning Jia, Jinfeng Ye, Xianwei Liu, Chang-Cheng Liu,* Hongzhi Cao*. A Redox-
Controlled Substrate Engineering Strategy for Site-Specific Enzymatic Fucosylation. Angew. Chem. Int. Ed. 2022, 61,
e202211032.
7. Jinfeng Ye, Kan Zhong, Zhi-Fei Hu*, Chang-Cheng Liu, Ming Li, Peng Wu*, Hongzhi Cao*. Sugar auxiliary group-
assisted diversity-oriented enzymatic modular synthesis of 0-series ganglioside glycans. Angew. Chem. Int. Ed. 2024,
e202418929.
8. Xuanjun Wu, Jinfeng Ye, Andrew T. DeLaitsch, Zahra Rashidijahanabad, Shuyao Lang, Tayeb Kakeshpour, Yuetao
Zhao, Sherif Ramadan, Paulo Vilar Saavedra, Vilma Yuzbasiyan-Gurkan, Herbert Kavunja, Hongzhi Cao*, Jeffrey C.
Gildersleeve*, Xuefei Huang*. Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome the Hydrolytic
Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development. Angew. Chem. Int. Ed. 2021, 60,
24179-24188.
9. Caicai Meng, Aniruddha Sasmal, Yan Zhang, Tian Gao, Chang-Cheng Liu, Naazneen Khan,Ajit Varki, Fengshan
Wang,* Hongzhi Cao*. Chemoenzymatic assembly of mammalian O-mannose glycans. Angew. Chem. Int. Ed. 2018,
57, 9003-9007.
10. Hui Xia, Kan Zhong, Yun Li, Jinfeng Ye*, Di Wang, Chao Cai, Wanmeng Mu, Chang-Cheng Liu*, Hongzhi Cao*.
Regioselective enzymatic galactosylation enabled divergent synthesis of asymmetrical biantennary human milk
oligosaccharides. ACS Catal. 2024, 14, 13390–13399.

*以上信息由高级会员个人更新和维护。