李翀

男， 西南大学药学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2001/09-2005/07 四川大学华西药学院药学专业（获理学学士学位）
2005/09-2010/06 复旦大学药学院药剂学专业(保送直博并获理学博士学位)
2008/01-2009/04 美国马里兰大学医学院 多肽/蛋白质化学（联合培养博士生）
2010/07-现在 西南大学药学院特聘教授、教授
2019/11-现在 西南大学医学研究院 副院长

研究领域和兴趣

药物化学生物学（天然药物、药物递送与药物载体）

主要业绩

围绕探索恶性肿瘤、中枢神经系统疾病等高效低毒治疗新模式开展工作，利用仿生策略克服药物靶向递送面临的多重“矛盾”，特别关注脂质递药系统的功能设计和体内命运调控。先后以通讯作者身份指导研究生在Signal Transduct Target Ther、J Controlled Release、Acta Pharm Sin B，Angew Chem Int Ed，Nano Letters，ACS Nano，Adv Func Mater等学术期刊发表系列论文。副主编专著一部《Drug Delivery to Tumors - Recent Strategies and Techniques》（Springer Nature，in press）。先后主持国家自然科学基金4项及省部级重点项目、制药企业联合研发项目10余项。曾获全国优秀博士学位论文奖和中国药学会-中恒青年药剂学奖，作为主要完成人获得教育部高等学校自然科学奖二等奖1项。入选青年长江学者。

代表成果

1.Wang X, Zheng W, Shen Q, Wang Y, Tseng Y, Luo Z, Wang X, Shi L, Li C*, Liu J*. Identification and construction of a novel biomimetic delivery system of paclitaxel and its targeting therapy for cancer. Signal Transduct Target Ther. 2021,6,1,33
2.Wang X, Wu J, Liu X, Tang K, Cheng L, Li J, Tang Y, Song X, Wang X*, Li C*. Engineered liposomes targeting the gut-CNS Axis for comprehensive therapy of spinal cord injury. J Control Release. 2021,331,390-403
3. Tang K, Wang X, Niu M, Wang X, Zhou G, Shi J, Yu Y, Chen Z, Li C*. Augmenting the Precise Targeting of Antimicrobial Peptides (AMPs) and AMP-Based Drug Delivery via Affinity-Filtering Strategy. Adv Funct Mater. 2022, 2111344
4. Li J, Tang W, Yang Y, Shen Q, Yu Y, Wang X, Fu Y*, Li C*. A Programmed Cell-Mimicking Nanoparticle Driven by Potato Alkaloid for Targeted Cancer Chemoimmunotherapy. Adv Healthc Mater. 2021,10(13):e2100311.
5. Cheng L, Niu M, Yan T, Ma Z, Huang K, Yang L, Zhong X, Li C*. Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections. Acta Pharm Sin B. 2021, 11(10):3220-3230 (Current cover paper)
6.Tang Y, Wang X, Li J, Nie Y, Liao G, Yu Y, Li C*. Overcoming the reticuloendothelial system barrier to drug delivery with a“don’t-eat-us”strategy. ACS Nano. 2019,13,11,13015-13026 (Reported by Chemical Engineering News in the "Pharmaceutics" column)
7. Xie J, Shen Q, Huang K, Zheng T, Cheng L, Zhang Z, Yu Y, Liao G, Wang X*, Li C*. Oriented assembly of cell-Mimicking nanoparticles via a molecular affinity strategy for targeted drug delivery. ACS Nano. 2019,13,5,5268-5277 (Current cover paper)
8. Tang Y, Wu S, Lin J, Cheng L, Zhou J, Xie J, Huang K, Wang X, Yu Y, Chen Z, Liao G, Li C*. Nanoparticles targeted against cryptococcal pneumonia by interactions between chitosan and its peptide ligand. Nano Lett.2018,18,10,6207-6213 (Recommended as the exceptional paper by F1000 Prime)
9. Tang Y, Wu S, Lin J, Cheng L, Zhou J, Xie J, Huang K, Wang X, Yu Y, Chen Z, Liao G, Li C*. Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the "hidden" part of membrane receptors for targeted drug delivery. Chem Commun.2017,53,81,11114-11117.
10. Zhang Y, Deng C, Liu S, Wu J, Chen Z, Li C*, Lu W. Active targeting of tumors through conformational epitope imprinting. Angew Chem Int Ed Engl.2015, 54,17, 5157-60.
11. Li C, Wang Y, Zhan H. Liposomes with ginsenoside as membrane material and preparations and use thereof. US20170172920A1, CA2994032, CN201610693884.2, WO2017028811A1, EP16836675.5, AU2016309847, JP2018-528372.

*以上信息由高级会员个人更新和维护。