王周玉

女， 西华大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1995.09—1999.07 西南石油学院攻读学士学位
1999.09—2002.07 西南石油学院攻读硕士学位
2002.07—2003.04 四川工业学院生物工程系担任教学、科研工作
2003.04－2005.02 西华大学生物工程学院担任教学、科研工作
2005.02－2007.06 西华大学理化学院担任教学、科研工作
2004.09－2007.07 中国科学院成都生物所攻读博士学位（在职不脱产）
2007.07-2013.04 西华大学生物工程学院担任教学、科研工作
2013.05-2014.12 西华大学理化学院担任副院长、教学、科研工作
2015.01-2021.10 西华大学理学院担任副院长、教学、科研工作
2021.11-今 西华大学理学院担任院长、教学、科研工作

研究领域和兴趣

有机合成、新药研发、连续流微反应、有机荧光材料

主要业绩

王周玉，女，博士，教授，院长，硕士生导师，四川省学术和技术带头人后备人选，四川省杰出青年基金获得者，四川省创新群体负责人，第九届四川省化学化工学会常务理事，第六届四川省科技青年联合会常务理事。1999年获西南石油学院化学工程与工艺专业本科学位，2002年获西南石油学院应用化学专业硕士学位，2007年获中国科学院成都生物所药物化学专业博士学位。主要从事生物活性分子的合成及应用、连续流微反应工艺、创新药物研发、有机荧光材料等方面的科研工作。近几年作为项目负责人主持国家自然科学基金、四川省科技厅项目等20余项。围绕医药中间体、合成方法学发表相关论文70余篇，包括Chinese Chemical Letters、Sensor. Actuat. B-Chem.、Organic Letters、Organic Chemistry Frontiers、European Journal of Medicinal Chemistry、Bioorganic & Medicinal Chemistry等SCI收录论文50余篇。申请专利30余项，国际专利3项，授权20余项。

代表成果

主要学术论文：
[1] Chengshuang Liao, Feishi Shan, Yinxia Zhu, Haodong Mi, Yanhong Liu, Qiao Song, Chuanfeng Wang, Leyong Wang * , Zhouyu Wang*. Self-ratiometric Photoluminescence Carbonized Polymer Dots with Junas Structure for Hypochlorite Selective Sensing. Sensor. Actuat. B-Chem., 2024, 420, 136453.

[2] Li Yan, Chengshuang Liao, Yinxia Zhu, Haodong Mi, Shanshan Jiang, Feishi Shan, Yanhong Liu, Yahui Zhang, Qian Zhou, Zhouyu Wang*, Xiaoqi Yu, Carbonized Polymer Dots with Aggregation-Induced Effect for Type I Photodynamic Therapy，ACS Applied Nano Materials, 2023, 6 (14):13320-13329.

[3] Yahui Zhang, Haoyu Xia, Mengdie Yang, Hairong Li, Feishi Shan, Yilong Chen, Xue Yue, Zhouyu Wang*, Xiaoqi Yu*, Carbon dots with two-photon fluorescence imaging for efficient synergistic trimodal therapy, Chinese Chemical Letters,2023, 34 (09): 108197.

[4] Feishi Shan, Tingrui Zhang, Chengshuang Liao, Jing Zhang, Li Yan, Yanman Liu, Zhixing Cao, Min Wang, Yahui Zhang, Leyong Wang, Zhouyu Wang*, Xiaoqi Yu, Red/NIR emission carbonized polymer dots based on citric acid-benzoylurea and their application in lymph nodes imaging，Chinese Chemical Letters. 2023, 34(11):108402.

[5] Feishi Shan, Jing Zhang, Chengshuang Liao, Zhouyu Wang*, Leyong Wang*，Mechanisms of photoluminescence in the molecular state of carbon dots prepared from o-phenylenediamine，Chinese Chemical Letters. 2023, 34(07): 108107.

[6] Qian Zhou, Shanqiang Wang, Xiaoyun Ran, Linzhi Shen, Xiaolin Luo, Gui Wang ,Hui Yang, Zhouyu Wang*, Xiaoqi Yu*, The water-soluble bicyclic 2-pyridone-based fluorescent probe for fast and selective detection of hypochlorite. Chinese Chemical Letters. 2023, 34(11):107922.

[7] Yahui Zhang, Hairong Li, Mengdie Yang, Wenbo Dai, Jianbing Shi, Bin Tong, Zhengxu Cai*, Zhouyu Wang*, Yuping Dong, Xiaoqi Yu*, Organic room-temperature phosphorescencematerials for bioimaging, Chem. Commun., 2023, 59, 5329–5342.

[8] Xiao-Long He, You-Wu Wen, Hechen Li, Shan Qian,* Mengyang He, Qiao Song, and Zhouyu Wang*，Diastereoselective Synthesis of Dihydrobenzofuran-Fused Spiroindolizidines via Double-Dearomative [3 + 2] Cycloadditions，J. Org. Chem. 2023, 88, 493−503.

[9] Qiao Song *, Sheng Wang, Xiangui Lei, Yan Liu , Xin Wen and Zhouyu Wang,* One-Pot Route from Halogenated Amides to Piperidines and pyrrolidines，Molecules，2022，27，4698-4705.

[10] Qiao Song*, Xiangui Lei , Sheng Yang , Sheng Wang , Jianhui Wang , Jiujun Chen , Yong Xiang, Qingwu Huang and Zhouyu Wang*，Continuous-flow Synthesis of Nitro-o-xylenes: Process Optimization, Impurity Study and Extension to Analogues，Molecules， 2022， 27， 5139-5148.

[11] Feishi Shan, Lijuan Fu, Xiangyu Chen, Xiangyan Xie, Chengshuang Liao, Yinxia Zhu,Haoyu Xia, Jing Zhang, Li Yan, Zhouyu Wang*, Xiaoqi Yu*, Waste-to-wealth: functional biomass carbon dots based on bee pollen waste and application，Chin. Chem. Lett.，2022, 33, 2942-2948.

[12] Yuxiang Wu, Dan Ren, Cheng Gao, Junyan Li, Bo Du, Zhouyu Wang*, Shan Qian*, Recent advances for alkaloids as botanical pesticides for use in organic agriculture, International Journal of Pest Management, 2021, https://doi.org/10.1080/09670874.2021.1917723.

[13] Xiao-Long He, Cheng Wang, You-Wu Wen, Yi-Bing Zhao, Huan Yang, Shan Qian, Lingling Yang* and Zhouyu Wang*, Highly stereoselective dearomatizative [3+2] cycloadditon of cyclic pyridinium ylides to access spiro-indolizidine scaffolds. Org. Chem. Front., 2021, 8, 5847-5851.

[14] Xiao-Long He, Cheng Wang, You-Wu Wen, Zhouyu Wang,* and Shan Qian*, Recent Advances in Catalytic Atroposelective Construction of Pentatomic Heterobiaryl Scaffolds. ChemCatChem. 2021, 13, 3547 – 3564.

[15] Xiaoyun Ran, Qian Zhou, Jin Zhang, Shanqiang Wang, Gui Wang, Hui Yang, Xiaochun Liu, Zhouyu Wang* and Xiaoqi Yu*, A solvent-free and efficient synthesis of bicyclic 2-pyridone derivatives for endoplasmic reticulum imaging, Organic Chemistry Frontiers, 2021, 8, 3631-3638.

[16] Qiao Song, Yan Liu, Linlin Cai, Xinyu Cao, Shan Qian *, Zhouyu Wang *, One-pot tandem route to fused indolizidines and quinolizidines: Application in the synthesis of alkaloids and bioactive compounds. Chinese Chemical Letters, 2021, 32, 1713–1716.

[17] Feishi Shan, Haoyu Xia, Xiangyan Xie, Lijuan Fu, Hui Yang, Qian Zhou, Yuanyuan Zhang, Zhouyu Wang*, Xiao Qi Yu. Novel N-doped carbon dots prepared via citric acid and benzoylurea by green synthesis for high selectivity Fe(III) sensing and imaging in living cells.Microchemical Journal, 2021,167, 106273-106283.

[18] Xiaoyun Ran, Yan Long, Sheng Yang, Changjiang Peng, Yuanyuan Zhang, Shan Qian, Zhenju Jiang, Xiaomei Zhang, Lingling Yang, Zhouyu Wang* and Xiaoqi Yu*，A novel route to unsymmetrical disubstituted ureas and thioureas by HMPA catalyzed reductive alkylation with trichlorosilane，Org. Chem. Front., 2020, 7, 472-481.

[19] Huan Yang, Wanying Zhang, Sumudu Athukorale, Zhiguo Liu, Shengli Zou, Bruno Donnadieu, Zhouyu Wang*, and Dongmao Zhang*，Dithiosulfindene Adsorption and Reaction on Gold Nanoparticles in Water，J. Phys. Chem. C2020, 124, 686−692.

[20] Hui Liu, Yingkun Yan, Jiayan Zhang, Min Liu, Shaobing Cheng, Zhouyu Wang* and Xiaomei Zhang*, Enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines, Chem. Commun., 2020, 56, 13591-13594.

[21] Jiayan Zhang, Min Liu, Min Huang, Hui Liu, Yingkun Yan, Zhouyu Wang* and Xiaomei Zhang*, Enantioselective dearomative [3 + 2] annulation of 3-hydroxy chromanones with azonaphthalenes, Org. Chem. Front., 2020, 7, 3160–3165.

[22] Wei Xu, Hao Yao, Xing Zhang, Changjiang Peng, Ling Li, Yuanyuan Zhang, Shan Qian, Lingling Yang,* Zhouyu Wang*, K2CO3 Promoted Cascade Reaction for the Preparation of 1H-Imidazol-4-yl-1-amine Derivatives, Letters in Organic Chemistry, 2020, 17, 127-132.

[23] Lingling Yang, Feng Chen, Cheng Gao, Jiabao Chen, Junyan Li, Siyan Liu, Yuanyuan Zhang, Zhouyu Wang*, Shan Qian*. Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy, Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35, 152-164.

[24] Lijiao Wang, Chao Li , Wei Chen , Chen Song , Xing Zhang , Fan Yang , Chen Wang , Yuanyuan Zhang , Shan Qian , Zhouyu Wang* and Lingling Yang*, Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors, Molecules, 2019, 24, 2724.

[25] Huan Yang, Guanglin Weng, Dongmei Fang, Changjiang Peng, Yuanyuan Zhang, Xiaomei Zhang* and Zhouyu Wang*，Enantioselective Conjugate Hydrosilylation of α,β-Unsaturated Ketones，RSC Adv., 2019, 9, 11627–11633.

[26] Xingjie Dai, Guanglin Weng, Shuowen Yu, Hui Chen, Jiayan Zhang, Shaobing Cheng, Xiaoying Xu, Weicheng Yuan, Zhouyu Wang*, Xiaomei Zhang*， One-pot diastereo- and enantioselective hydrosilylation–transacylation of α-acyloxy β-enamino esters，Org. Chem. Front., 2018, 5, 2787-2793.

[27] Guangyou Jiang, Min Liu, Dongmei Fang, Ping Tan, Min Huang, Taiping Zhou, Zhenju Jiang, Zhihong Xu and Zhouyu Wang*，Base promoted solvent-free four components reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates: an improvement of the Ramachary reductive coupling/alkylaiton reaction，RSC Adv., 2018, 8, 8961–8964.

[28] Lingling Yang （*）, Xiaobo Ma , Chen Yuan , Yanying He , Ling Li , Sha Fang , Wei Xia ，Tao He, Shan Qian, Zhihong Xu, Guobo Li, Zhouyu Wang*， Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacet- amide derivatives as new potent and selective human sirtuin 2 inhibitors，European Journal of Medicinal Chemistry，2017，134，230-241.

[29] Guanglin Weng, Xiaobo Ma, Dongmei Fang, Ping Tan, Lijiao Wang, Linlin Yang, Yuanyuan Zhang, Shan Qian and Zhouyu Wang*，Thiourea catalysed reduction of a-keto substituted acrylate compounds using Hantzsch ester as a reducing agent in water，RSC Advances,2017, 7, 22909 – 22912.

[30] Ling-Ling Yang, Yan-Ying He, Quan-Long Chen, Shan Qian, Zhouyu Wang*. Design, Synthesis of New 9-Substitued Norharmane Derivatives as Potential Sirt5 Inhibitors. Journal of Heterocyclic Chemistry, 2017，54 , 2，1457–1466.

[31] Tao He，Ronghua Shi，Yimou Gong，Guangyou Jiang，Ming Liu，Shan Qian，Zhouyu Wang*，Base promoted cascade approach for the preparation of reduced Knoevenagel adducts using Hantzsch esters as reducing agent in water，Synlett，2016，27, 1864-1869.

[32] Shan Qian, Tao He, Wei Wang, Yanying He, Man Zhang, Lingling Yang, Guobo Li, Zhouyu Wang*, Discovery and preliminary structure–activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties, Bioorganic & Medicinal Chemistry, 2016, 24: 6194–6205.

[33] Shan Qian, Man Zhang, Quanlong Chen, Yanying He, Wei Wang, Zhouyu Wang* IDO as a drug target for cancer immunotherapy: recent developments in IDO inhibitors discovery. RSC Advances, 2016, 7575-7581.

*以上信息由高级会员个人更新和维护。