汪君

女， 香港浸会大学化学系， 教授/研究员/教授级高工或同等级别

学习/工作经历

1996.09-2000.07 兰州大学化学系，本科学生
2002.09-2005.08 中科院上海有机所，硕士学生
2006.12-2009.12 香港理工大学应用生物与化学科技系，博士生
2010.03-2011.02 美国德州大学西南医学中心，博士后
2011.03-2012.08 香港浸会大学中医药学院研究助理教授
2012.08-2020.06 南方科技大学化学系助理教授/tenured副教授
2020.07-2023.06 香港浸会大学化学系副教授
2023.07至今 香港浸会大学化学系教授
2023.07至今 南方科技大学化学系访问教授

研究领域和兴趣

不对称催化，有机合成方法学，药物化学

主要业绩

1. 黄酮类化合物的不对称合成及其生物活性应用
2. 含膦手性配体的设计与合成
3. 非活化双键的氢官能团化反应研究

代表成果

1. 论文
1) Construction of Tetrasubstituted α-Amino- and α-Alkoxy- Phosphine Oxides via Pd-catalyzed Regio- and Enantioselective Hydrophosphinylation of Dienes. Cheng, J.-T.; Yuan, X.; Yang, Z.; Liu, K.; Wang, J.* Angew. Chem. Int. Ed. 2025, 64, e202519578
2）Enantio- and Regioselective Cascade Hydroboration of Methylenecyclopropanes for Facile Access to Chiral 1,3- and 1,4-bis(boronates). Zhou, J.; Meng, L.; Yang, Z.; Wang, J.* Adv. Sci. 2024, 11, 2400096 (Inside cover).
3）Palladium-catalyzed Enantio-and Regioselective Ring-Opening Hydrophosphinylation of Methylenecyclopropanes. Zhou, J.; Meng, L.; Lin, S.; Cai, B.; Wang, J.* Angew. Chem. Int. Ed. 2023, 62, e202303727
4）Asymmetric Hydrophosphinylation of Alkynes: Facile Access to Axially Chiral Styrene-Phosphines. Cai, B.; Cui, Y.; Zhou, J.; Wang, Y.-B.; Yang, L.*; Tan, B.*; Wang, J.* Angew. Chem. Int. Ed. 2023, 62, e202215820
5）Asymmetric synthesis of flavanols via Cu-catalyzed kinetic resolution of chromenes and their anti-inflammatory activity. Yang, Q.; Wang, Z.; Hor, C. H. H.; Xiao, H.; Bian, Z.*; Wang, J.* Sci. Adv. 2022, 8, eabm9603
6）Asymmetric access of γ-amino acids and γ-amino phosphonic acid derivatives via copper-catalyzed enantioselective and regioselective hydroamination. Yang, Z.-P.; Du, Q.-W.; Jiang, Y.-X.; Wang, J.* CCS Chem. 2022, 4, 1901–1911
7）Enantioselective palladium-catalyzed hydrophosphinylation of allenes with phosphine oxides: facile access to chiral allylic phosphine oxides. Yang, Z.-P.; Wang, J.* Angew. Chem. Int. Ed. 2021, 60, 27288 –27292
8） Kinetic Resolution and Dynamic Kinetic Resolution of Chromene by Rh-Catalyzed Asymmetric Hydroarylation, Yang, Q.; Wang, Y.; Luo, S.; Wang, J.* Angew. Chem. Int. Ed. 2019, 58, 5343-5347 (Highlighted in Synfacts, 2019, 15, 5343).
9) Asymmetric Hydrophosphination of Heterobicyclic Alkenes: Facile Access to Phosphine Ligands for Asymmetric Catalysis, Lu, Z.; Zhang, H.; Yang, Z.; Ding, N.; Meng, L.; Wang, J.* ACS Catal. 2019, 9, 1457-1463.
10) Asymmetric construction of atropisomeric biaryls via a redox neutral cross-coupling strategy, Qi, L.-W.; Li, S.; Xiang, S.-H.; Wang, J.*, Tan, B.* Nat. Catal., 2019, 314-323 (Highlighted by Chemical & Engineering News).

2. 专利
1）Flavan-3-ol analogs and anti-inflammatory activity. Wang, J.; Wang, Z.; Yang, Q.; Bian, Z. US Patent, Application No. 18/055,873, Filed on Nov. 22, 2021. Pub No. US20230159482A1, Patent No: 11952358, Issue date: April 09, 2024.
2）一种吲哚-二氢化萘类化合物及其制备方法和应用. 汪君, 李嗣锋, 王子豪, 卞兆祥. 专利号：ZL202010438007.7
3) 一种手性二氢黄酮类化合物及其衍生物及其制备方法和应用. 汪君, 熊东路，周文茜，陆志武. 专利号：ZL201710379364.9
4) 一种α-三氟甲硫基-β-氨基酮、酯、腈或酰胺化合物以及α-三氟甲硫基-β-氨基酸的制备方法. 汪君，金明宇，肖青，何其捷. 专利号：ZL201510896385.9
5) Asymmetric Synthesis of Norcantharidin Analogues by Alkynylation of Oxabenzonorborna -dienes and Their Anticancer Activities. Chan, A. S. C.; Fan, B.-M.; Wang, J.; Lin, C. Y.; Huang, C.; Yang, Q.-J.; Xu, J.-B.; Bian, Z.-X.; Lu, A.-P, Hu, J. Patent US 8835658B2, 2014.

*以上信息由高级会员个人更新和维护。