郭成

男， 浙江大学， 副教授/副研究员/高级工程师或同等级别

学习/工作经历

1.教育经历：
2008/09-2013/06，浙江大学化学系，博士
2006/02-2008/06，武汉大学生命科学学院，学士（双学位）
2004/09-2008/06，华中科技大学化学与化工学院，学士

2.研究工作经历：
2019/01-2019/09，加州大学河滨分校，访问学者
2018/06-2019/01，柏林工业大学，博士后
2014/03-2017/07，浙江大学医学院，博士后
2013/08-至今，浙江大学，助理研究员、副研究员

研究领域和兴趣

质谱分析，核酸修饰分析，代谢组学

主要业绩

近5年以第一作者/通讯作者在Analytical Chemistry, Analytica Chimica Acta, Chinese Chemical Letters, Journal of Proteome Research等期刊上发表SCI论文20余篇，以合作作者身份在Nature，JACS等期刊发表SCI论文多篇，授权发明专利2项。以第一完成人获得浙江省分析测试科学技术奖。承担国家自然科学基金面上项目等科研项目8项，作为学术骨干参加国家自然科学基金杰出青年基金、重点项目等多项。担任Chinese Chemical Letters青年编委及多个期刊的客座编辑。

代表成果

近5年以第一作者/通讯作者发表的10篇代表性论文：
(1) Yiqiu Hu, Zhijun Yuan, Xiujuan Hong, Jiayi Mu, Xiaoxiao Zhang, Zhihao Fang, Ying Yuan, Shu Zheng, Cheng Guo*. Pan-cancer analysis of DNA epigenetic modifications by hydrophilic interaction liquid chromatography-tandem mass spectrometry. Chinese Chemical Letters, 2023, 34, 108023.
(2) Zhihao Fang, Yiqiu Hu, Xiujuan Hong, Xiaoxiao Zhang, Tao Pan, Chi Pan, Shu Zheng*, Cheng Guo*. Simultaneous determination of methylated nucleosides by HILIC-MS/MS revealed their alterations in urine from breast cancer patients. Metabolites, 2022, 12, 973.
(3) Xiaoxiao Zhang, Yiqiu Hu, Xiujuan Hong, Mingwei Wang, Zhihao Fang, Xiaoji Cao, Kezhi Jiang*, Cheng Guo*. Determination of adenosine and its modifications in urine and plasma from breast cancer patients by hydrophilic interaction liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 2022, 1209, 123428.
(4) Ge Ma, Xiaoyong Zhao, Mengzhe Guo, Yaqin Liu, Keqiang Shi, Cheng Guo*, Yuanjiang Pan*. 6-Glycosylaminoquinoline-assisted LDI MS for detection and imaging of small molecules with enhanced detection selectivity and sensitivity. Analytica Chimica Acta, 2022, 1201, 339620.
(5) Cheng Guo*, Yiqiu Hu, Xiaoji Cao, Yinsheng, Wang*. HILIC-MS/MS for the Determination of Methylated Adenine Nucleosides in Human Urine. Analytical Chemistry, 2021, 93, 17060-17068.
(6) Rongrong Huang, Kexin Shen, Quan He, Yiqiu Hu, Cuirong Sun*, Cheng Guo*, Yuanjiang Pan*. Metabolic profiling of urinary chiral amino-containing biomarkers for gastric cancer using a sensitive chiral chlorine-labeled probe by HPLC-MS/MS. Journal of Proteome Research, 2021, 20, 3952-3962.
(7) Qin Chen#, Yiqiu Hu#, Zhihao Fang, Minfeng Ye, Jingqing Li, Suzhan Zhang, Ying Yuan*, Cheng Guo*. Elevated levels of oxidative nucleic acid modification markers in urine from gastric cancer patients: Quantitative analysis by ultra performance liquid chromatography-tandem mass spectrometry. Frontiers in Chemistry, 2020, 8, 606495.
(8) Cheng Guo*, Qin Chen, Jiani Chen, Jiekai Yu, Yiqiu Hu, Suzhan Zhang*, Shu Zheng. 8-Hydroxyguanosine as a possible RNA oxidative modification marker in urine from colorectal cancer patients: Evaluation by ultra performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 2020, 1136, 121931.
(9) Cheng Guo*, Cong Xie, Qin Chen, Xiaoji Cao, Mengzhe, Guo, Shu Zheng, Yinsheng Wang*. A novel malic acid-enhanced method for the analysis of 5-methyl-2’-deoxycytidine, 5-hydroxymethyl-2’-deoxycytidine, 5-methylcytidine and 5-hydroxymethylcytidine in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry. Analytica Chimica Acta, 2018, 1034, 110-118.
(10) Cheng Guo*, Cong Xie, Peili Ding, Guangming Qin, Weimin Mo, Xiaoji Cao*, Shu Zheng. Quantification of glycocholic acid in human serum by stable isotope dilution ultra performance liquid chromatography electrospray ionization tandem mass spectrometry. Journal of Chromatography B, 2018, 1072, 315-319.

*以上信息由高级会员个人更新和维护。