计剑

男， Zhejiang University， 教授/研究员/教授级高工或同等级别

学习/工作经历

1988.09-1992.06 浙江大学化学系 本科学生
1992.09-1997.08 浙江大学高分子科学与工程学系 博士学生
1997.08-至今 浙江大学高分子科学与工程学系 教师
1998.6-2000.6 国家公派到葡萄牙国家生物医学工程中心从事博士后研究
2004.12 浙江大学高分子科学与工程学系教授
2005.9-2005.12 德国海德堡大学高级访问学者
2018.6-至今 浙江大学生物医用大分子研究所所长

研究领域和兴趣

生物医用界面和生物医用材料

主要业绩

主要从事生物医用界面材料和植介入材料的应用基础研究，先后主持国家重点研发计划，国家自然科学基金委重点项目等，针对心血管原位再生材料的关键问题，发现并证明了复杂体内环境中细胞竞争行为对心血管内皮原位再生的关键作用，并成功研制了具有原位内皮再生功能的新型心血管支架，成果获浙江省科学技术奖一等奖；针对纳米微载体体内靶向的重要挑战，发现了两性离子纳米界面的生物学纳米效应；从宏观和微观两个层次，建立了复杂生命体系中实现高选择性生物医用界面的新方法和新理论，并致力于生物材料基因工程创新方法和应用示范的研究。近5年获国家发明专利授权20余项，以第一或通讯作者在包括Advanced Science, ACS NANO, Biomaterials 等期刊发表SCI收录论文120余篇，他引8000余次。国家杰出青年科学基金获得者(2010)，教育部长江特聘教授(2015), 国家“万人计划”科技创新领军人才（2016）。英国皇家化学会会士（2017）。Journal of materials Chemistry B副主编。中国生物材料协会理事和表界面工程分会副主任委员。

代表成果

论文：
1. Junjie Huang, Yanchao Xu, Yunfan Xue, Yue Huang, Xu Li, Xiaohui Chen, Yao Xu , Dongxiang Zhang, Peng Zhang*, Junbo Zhao*, Jian Ji *, Identification of Top-performance Antimicrobial Peptides from Whole Combinatorial Libraries via a Sequential Model Ensemble Machine Learning Pipeline, Nature Biomedical Engineering, 2023,10.1038/s41551-022-00991-2，https://www.nature.com/articles/s41551-022-00991-2
2. Yunfan Xue, Honglin Qian, Xu Li, Jing Wang, Kefeng Ren, and Jian Ji*，A deep-learning-based workflow to deal with the defocusing problem in high-throughput experiments, Bioactive Materials, 2022 ,11: 218–229.
3. Yun-fan Xue, Yang He, Jing Wang, Ke-feng Ren, Pu Tian,* and Jian Ji*，Label-Free and In Situ Identification of Cells via Combinational Machine Learning Models；Small Methods，2022, 6, 2101405
4. Xiaohui Chen, Haijie Han, Zhe Tang, Qiao Jin*, Jian Ji*, Aggregation-Induced Emission-based platforms for the treatment of bacteria, fungi, and viruses, Adv. Healthcare Mater., 2021, 202100736.
5. Dengfeng Hu, Lingyun Zou, Weijiang Yu, Fan Jia, Haijie Han, Ke Yao, Qiao Jin* and Jian Ji*, Relief of Biofilm Hypoxia Using an Oxygen Nanocarrier: A New Paradigm for Enhanced Antibiotic Therapy, Advanced Science, 2020, 7, 2000398
6. Dengfeng Hu,† Yongyan Deng,† Fan Jia, Qiao Jin,* and Jian Ji*，Surface Charge Switchable Supramolecular Nanocarriers for Nitric Oxide Synergistic Photodynamic Eradication of Biofilms，ACS Nano, 2020, 14, 347-359.
7. Yifan Gao, Jing Wang, Mengying Chai, Xu Li, Yongyan Deng, Qiao Jin*, and Jian Ji*, Size and Charge Adaptive Clustered Nanoparticles Targeting the Biofilm Microenvironment for Chronic Lung Infection Management, ACS Nano, 2020, 14, 5, 5686–5699.
8. Yongyan Deng, Fan Jia, Shengyu Chen, Zhida Shen, Qiao Jin,* Guosheng Fu, Jian Ji*, Nitric oxide as an all-rounder for enhanced photodynamic therapy: Hypoxia relief, glutathione depletion and reactive nitrogen species generation, Biomaterials, 2018, 187, 55-65
9. Tingting Chen, Hadi Bakhshi, Li Liu, Jian Ji*, and Seema Agarwal*, Combining 3D Printing with Electrospinning for Rapid Response and Enhanced Designability of Hydrogel Actuators, Advanced Functional Materials, 2018, 28, 180051
10. Haijie Han, Daniel Valdepeŕez, Qiao Jin,* Bin Yang, Zuhong Li, Yulian Wu, Beatriz Pelaz, Wolfgang J. Parak, Jian Ji*, Dual Enzymatic Reaction-Assisted Gemcitabine Delivery Systems for Programmed Pancreatic Cancer Therapy, ACS Nano, 2017, 11, 1281−1291.
11. Dengfeng Hu, Huan Li, Bailiang Wang, Zi Ye, Wenxi Lei, Fan Jia, Qiao Jin, Ke-Feng Ren, and Jian Ji*, Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm, ACS Nano, 2017, 11, 9330−9339.
12. He Zhang, Kefeng Ren*, Hao Chang, Jinlei Wang, Jian Ji*, Surface-mediated transfection of a pDNA vector encoding short hairpin RNA to downregulate TGF-b1 expression for the prevention of in-stent restenosis, Biomaterials, 2017, 116, 95-105.

13. X. Chen, K. Ren,* J. Zhang, D. Li, E. Zhao, Z. J. Zhao, Z. Xu, J. Ji*. Humidity-triggered self-Healing of microporous polyelectrolyte multilayer coatings for hydrophobic drug delivery. Adv. Funct. Mater.，2015, 25, 7470-7477
14. J. Wang, B. Li, Z. Li, K. Ren*, L. Jin, S. Zhang, H. Chang, Y. Sun, J. Ji*, Electropolymerization of dopamine for surface modification of complex-shaped cardiovascular stents, Biomaterials, 2014, 35, 7679-7689
15. Xiangsheng Liu, Yangjun Chen, Huan Li, Nan Huang, Qiao Jin, Kefeng Ren, Jian Ji*, Enhanced Retention and Cellular Uptake of Nanoparticles in Tumors by Controlling Their Aggregation Behavior, ACS Nano, 2013,7, 6244-6257
16. Yu Wei, Ying Ji, Lin-Lin Xiao, Quakui Lin, Jian-ping Xu, Kefeng Ren, Jian Ji*,Surface engineering of cardiovascular stent with endothelial cell selectivity for in vivo re-endothelialisation, Biomaterials 2013,34, 2588-2599
等

专利：
(1) 计剑; 任科峰; 黄威嫔; 陈夏超 ; 一种区域浸润性差异涂层及其制备方法, 2020-11-24, 中国, ZL201810316559.3ezh
(2) 计剑; 任科峰; 姚添甜 ; 一种基于主客体作用制备光动力抗菌涂层的方法及其产品和应用, 2019-7-5, 中国, CN201910604958.4
(3) 计剑; 任科峰; 黄威嫔 ; 一种图案化可逆多孔涂层及其制备方法, 2019-9-23, 中国, ZL201910900790.1
(4) 计剑; 任科峰; 汪璟 ; 一种自愈合抗菌涂层及其制备方法和应用, 2019-6-11, 中国, ZL201710267407.4
(5) 计剑; 任科峰; 汪璟 ; 一种聚电解质复合物涂层及其制备方法, 2020-10-13, 中国, ZL201711098931.X
(6) 计剑; 任科峰; 凡小利 ; 一种血液相容性的抗菌聚合物及其制备方法和应用, 2020-5-29, 中国, ZL201711337464.1
(7) 计剑; 任科峰; 黄威嫔; 陈夏超 ; 一种图形化涂层及其制备方法, 2020-9-8, 中国, ZL201810049452.7
(8) 计剑; 任科峰; 黄威嫔; 陈夏超 ; 一种图案化多孔聚合物涂层及其制备方法, 2019-8-13, 中国, ZL201810213280.2
(9) 计剑; 任科峰; 陈夏超 ; 一种利用聚电解质组装制备载药涂层的方法, 2014-10-21, 中国, CN201410558225.9
(10) 计剑; 任科峰; 汪璟 ; 一种自愈合支架复合涂层及其制备方法和应用, 2019-5-31, 中国, ZL201710266184.X
等


著作：
沈家骢，计剑，《超分子层状结构：界面及生物医学功能》，科学出版社，2016，北京

*以上信息由高级会员个人更新和维护。