贺晓鹏

男， 华东理工大学，化学与分子工程学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2023.01至今，国家肝癌科学中心，青年科技英才（兼职引进）
2018.01至今，华东理工大学，化学与分子工程学院，教授（博士生导师）
2014.09—2017.12，华东理工大学，化学与分子工程学院，副研究员
2013.06—2014.08，华东理工大学，化学与分子工程学院，讲师
2011.07—2013.06，华东理工大学，化学与分子工程学院，博士后（师从：陈凯先 院士）
2006.09—2011.06，华东理工大学，制药工程与技术，工学博士（师从：施小新 教授、龙亿涛 教授）
2008.07—2009.02，法国Cachan高等师范学校，生物有机，联合培养（师从：Juan Xie教授）
2002.09—2006.06，华东理工大学，应用化学，学士

研究领域和兴趣

糖化学生物学、分析化学

主要业绩

本人长期从事疾病关联生物大分子靶向识别与功能调控的分子探针创制工作，开拓了以光活性标签修饰天然生物配体（如糖类与肽类）引导分子自组装，从而构建“控制激活型”生物（大）分子探针的独特化学生物学研究策略，坚持以临床需求为导向，在疾病相关生物分子本征动态属性的细胞原位探测（诊）与功能调控（疗）领域形成了鲜明的交叉学科研究特色。2015年来代表性论文包括1篇Sci. Bull., 3篇J. Am. Chem. Soc., 3篇Angew. Chem. Int. Ed., 1篇 Nat. Commun., 1篇Chem, 5篇Chem. Sci.和5篇Chem. Soc. Rev.，所有论文他引2343次（H因子33），ESI高被引论文11篇。获中国化学会青年化学奖、中国化学会化学生物学突出贡献奖（35周岁以下）、Thieme Chemistry Journals Award，担任《科学通报》与《高等学校化学学报》化学生物学专区青年编委。拟聚焦原创性动态荧光探针原位解译疾病演进过程的基础研究与临床应用。

代表成果

Superresolution imaging of antibiotic-induced structural disruption of bacteria enabled by photochromic glycomicelles
X.-L. Hu†, H.-Q. Gan†, W.-Z. Gui†, K.-C. Yan, J. L. Sessler*, D. Yi*, H. Tian, X.-P. He*
Proc. Natl. Acad. Sci. U. S. A. 2024, 121, e2408716121.

Fluorogenic Peptide Sensor Array Derived from Angiotensin-Converting Enzyme Classifies Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern
W.-T. Dou†, P.-H. Tong†, M. Xing†, J.-J. Liu, X.-L. Hu, T. D. James*, D.-M. Zhou*, X.-P. He*
J. Am. Chem. Soc. 2024, 146, 21017–21024.

Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer.
W.-T. Dou, P. Qiu, Y.-Y. Shi, L. Zhu, C. Guo, N. Li, Y. Zang, T.-T. Liu, S.-W. Zhao, Y.-F. Pan, L.-W. Dong, J. L. Sessler*, Y.-X. Tan*, J. Li*, H.-Y. Wang*, H. Tian, X.-P. He*
J. Am. Chem. Soc. 2023, 145, 17377–17388.

Phenotyping of Methicillin-Resistant Staphylococcus aureus Using a Ratiometric Sensor Array.
X.-L. Hu†, H.-Q. Gan†, Z.-Y. Qin, Q. Liu, M. Li*, D.-J. Chen*, J. L. Sessler*, H. Tian, X.-P. He*
J. Am. Chem. Soc. 2023, 145, 8917-8926.

Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox.
X.-L. Hu†, A. C. Sedgwick†*, D. N. Mangel†, Y. Shang, A. Steinbrueck, K. Yan, L. Zhu, D. W. Snelson, S. Sen, C. V. Chau, G. Juarez, V. M. Lynch, X.-P. He*, J. L. Sessler*
J. Am. Chem. Soc. 2022, 144, 7382–7390.

A homogeneous high-throughput array for the detection and discrimination of influenza A viruses.
W.-T. Dou†, X. Wang†, T. Liu, S. Zhao, J. Liu, Y. Yan, J. Li, C. Zhang, A. C. Sedgwick, H. Tian, J. L. Sessler*, D. M. Zhou*, X.-P. He*
Chem 2022, 8, 1750-1761.

Fluorescent probes for the detection of disease-associated biomarkers.
W.-T. Dou†, H.-H. Han†, A. C. Sedgwick, G.-B. Zhu, Y. Zang, X.-R. Yang*, J. Yoon*, T. D. James*, J. Li*, X.-P. He*
Sci. Bull. 2022, 67, 853-878. (ESI highly cited paper)

Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties.
A. C. Sedgwick†, K.-C. Yan†, D. N. Mangel†, Y. Shang, A. Steinbrueck, H.-H. Han, J. T. Brewster II, X.-L. Hu, D. W. Snelson, V. M. Lynch, H. Tian, X.-P. He*, J. L. Sessler*
J. Am. Chem. Soc. 2021, 143, 1278-1283. (ESI highly cited paper)

Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers.
X. Chai†, H.-H. Han†, A. C. Sedgwick†, N. Li, Y. Zang, T. D. James, J. Zhang*, X.-L. Hu, Y. Yu, Y. Li, Y. Wang, J. Li*, X.-P. He*, H. Tian
J. Am. Chem. Soc. 2020, 142, 18005-18013.

Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy.
J.-B. Jiao†, G.-Z. Wang†, X.-L. Hu†, Y. Zang, S. Maisonneuve, A. C. Sedgwick, J. L. Sessler*, J. Xie*, J. Li*, X.-P. He*, H. Tian
J. Am. Chem. Soc. 2020, 142, 1925-1932.

A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad Spectrum Antimicrobial Activity against Drug Resistant Bacteria.
Z.-H. Yu†, X. Li†, F. Xu†, X.-L. Hu, J. Yan, N. Kwon, G.-R. Chen, T. Tang, X. Dong, Y. Mai*, D. Chen*, J. Yoon*, X.-P. He*, H. Tian
Angew. Chem. Int. Ed. 2020, 59, 3658-3664.

Bio-Conjugated Advanced Materials for Targeted Disease Theranostics.
X.-L. Hu, N. Kwon, K.-C. Yan, A. C. Sedgwick, G.-R. Chen, X.-P. He*, T. D. James*, J. Yoon*
Adv. Funct. Mater. 2020, 30, 1907906.

Multivalent Glycosheets for Double Light–Driven Therapy of Multidrug-Resistant Bacteria on Wounds
X.-L. Hu, L.-Y. Chu, X.-J. Dong, G.-R. Chen, T.-T. Tang, D.-J. Chen*, X.-P. He*, He Tian
Adv. Funct. Mater. 2019, 29, 1806986.

Self-assembled sialyllactosyl probes with aggregation-enhanced properties for ratiometric detection and blocking of influenza viruses.
W.-T. Dou, Z.-Y. Qin, J. Li, D.-M. Zhou, X.-P. He*
Sci. Bull. 2019, 64, 1902-1909.

Lightening up Membrane Receptors with Fluorescent Molecular Probes and Supramolecular Materials.
X.-P. He, H. Tian*
Chem 2018, 4, 246-268. (ESI highly cited paper; Invited review)

An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates.
A. C. Sedgwick†, W.-T. Dou†, J.-B. Jiao, L. Wu, G. T. Williams, A. T. A. Jenkins, S. D. Bull, J. L. Sessler*, X.-P. He*, T. D. James*
J. Am. Chem. Soc. 2018, 140, 14267-14271.

Photo-Controlled Fluorescence “Double-Check” Bioimaging Enabled by a Glycoprobe-protein Hybrid.
Y. Fu†, H.-H. Han†, J. Zhang*, X.-P. He*, B. L. Feringa, H. Tian*
J. Am. Chem. Soc. 2018, 140, 8671-8674.

Supramolecular Nanostructures of Structurally Defined Graphene Nanoribbons in Aqueous Phase.
Y. Huang, W.-T. Dou, F. Xu, H.-B. Ru, Q. Gong, D. Wu, D. Yan, H. Tian, X.-P. He*, Y. Mai*, X. Feng
Angew. Chem. Int. Ed. 2018, 57, 3366-3371. (Very Important Paper)

Remote Light-Controlled Intracellular Target Recognition by Photochromic Fluorescent Glycoprobes.
J. Zhang, Y. Fu, H.-H. Han, Y. Zang, J. Li*, X.-P. He*, B. L. Feringa, H. Tian*
Nat. Commun. 2017, 8, 987. (ESI highly cited paper; ESI hot paper; Highlighted by Sci. China Chem.)

Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues.
Y.-H. Ma†, W.-T. Dou†, Y.-F. Pan, L.-W. Dong, Y.-X. Tan, X.-P. He*, H. Tian, H.-Y. Wang*
Adv. Mater. 2017, 29, 1604253. (ESI highly cited paper; Inside back cover)

Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet.
D.-K. Ji, Y. Zhang, Y. Zang, J. Li*, G.-R. Chen, X.-P. He*, H. Tian
Adv. Mater. 2016, 28, 9356-9363. (ESI hot paper)

Rapid Identification of the Receptor-Binding Specificity of Influenza A Viruses by Fluorogenic Glycofoldamers.
X.-P. He*, Y.-L. Zeng, X.-Y. Tang, N. Li, D.-M. Zhou*, G.-R. Chen, H. Tian*
Angew. Chem. Int. Ed. 2016, 55, 13995-13999. (ESI hot paper; Inside back cover)

Simultaneous Detection of Diverse Glycoligand-Receptor Recognitions Using a Single-Excitation, Dual-Emission Graphene Composite
D.-K. Ji, G.-.R Chen, X.-P. He*, H. Tian
Adv. Funct. Mater. 2015, 25, 3483-3487.

Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite.
H.-L. Zhang, X.-L. Wei, Y. Zang, J.-Y. Cao, S. Liu, X.-P. He*, Q. Chen, Y.-T. Long, J. Li*, G.-R. Chen*, K. Chen
Adv. Mater. 2013, 25, 4097-4101. (Front cover)

Epimeric Monosaccharide-Quinone Hybrids on Gold Electrodes toward the Electrochemical Probing of Specific Carbohydrate–Protein Recognitions.
X.-P. He, X.-W. Wang, X.-P. Jin, H. Zhou, X.-X. Shi, G.-R. Chen, Y.-T. Long*
J. Am. Chem. Soc. 2011, 133, 3649-3657.

*以上信息由高级会员个人更新和维护。