白立改

女， 河北大学， 副教授/副研究员/高级工程师或同等级别

学习/工作经历

1997.9-2001.6 河北大学 化学 学士
2005.9-2008.6 河北大学 药物分析学 硕士
2009.9-2012.6 河北大学 分析化学 博士
2013.1-现在 河北大学药学院/河北大学综合实验中心 副教授/副主任

研究领域和兴趣

分离材料；中药分析

主要业绩

1. 国家自然科学青年科学基金，21505030，卟啉功能化分离材料的制备及其对血浆疏水蛋白质的分子识别性能研究，2016-01至2018-12，主持
2. 河北省自然科学基金面上项目，B2015201024，基于卟啉修饰的液相色谱整体固定相的制备及其分子识别性能研究，2015-01至2017-12，主持
3. 河北省自然科学基金面上项目, B2020201002, 基于多维孔棒状吸附剂的在线固相萃取系统构建及生物样品分析, 2020-01 至 2022-12, 主持
4. 河北省高等学校科学技术研究项目, ZD2022079, 基于功能化棒状材料的中药组方活性成分在线萃取分离系统构建, 2022-01 至 2024-12,主持
5. 河北省自然科学基金基础研究专项，H2026201033，冀产黄芩抗动脉粥样硬化质量标志物发掘与道地性效价分级研究，2026-01至2028-12，主持
6.复杂样品中痕量物质卫生检测新技术研究及应用, 河北省科技进步二等奖, 2019 （闫宏远; 白立改; 韩丹丹; 韩晔红; 杨春柳; 乔晓强; 刘海燕）

代表成果

1. Sinan Lu, Xinli Yang, Siliang Han, Hang Zhan, Yanan Yuan, Ligai Bai*, Aromatic cage-functionalized porous separation material: Design, synthesis and application in selective extraction of crotonylated proteins from human plasma, Journal of Chromatography A 1775 (2026). DOI: 10.1016/j.chroma.2026.466937
2.Liyue Hou, Feiyu Ma, Xiaoya Jiang, Xinli Yang, Chao Li, Xiaoyu Zhang*, Ligai Bai*, Synthesis and application of phenyl-functionalized adsorbents: High-efficiency adsorptive extraction of phenolic and lactone active components from Ganjianglingzhu decoction, Microchemical Journal 220 (2026). DOI: 10.1016/j.microc.2025.116460
3.Sihan Liu, Ligai Bai*, Xudong Wang, Qiqiang Wang, Dexian Wang, Uwe T. Bornscheuer, Yufei Ao*, Machine learning-guided protein engineering to improve the catalytic activity of transaminases under neutral pH conditions, Organic chemistry Frontiers, 12(2025). DOI: 10.1039/D5QO00423C
4. Liyue Hou, Zhen Zhang, Siqi Li, Ligai Bai*, Specific extraction of S-adenosylhomocysteine from urine with boronate affinity mechanism based on a tube-tip adsorbent, Analytica Chimica Acta 1348 (2025). 10.1016/j.aca.2025.343811
5.Changqing Yu, Tiantian Xie, Sihan Liu, Ligai Bai*, Fabrication of a biochar-doped monolithic adsorbent and its application for the extraction and determination of coumarins from Angelicae Pubescentis Radix, Journal of Chromatography A, 1714 (2024) . DOI: 10.1016/j.chroma.2023.464564
6.Miaomiao Liu, Sinan Lu, Haiyan Liu, Hongyuan Yan, Ligai Bai*, Determination and isolation of purpurin and mollugin from Rubiae Radix ET Rhizoma based on a monolithic adsorbent prepared by bio-monomer, Microchemical Journal, 190 (2023). DOI: 10.1016/j.microc.2023.108644
7. Lu Liu, Sinan Lu, Haiyan Liu, Ligai Bai*, A simple and efficient method for the extraction and purification of tuberostemonine from Stemonae Radix using an amide group-based monolithic cartridge, Separation and Purification Technology, 300 (2022). DOI: 10.1016/j.seppur.2022.121843
8.Yunting Mao, Liyue Hou, Ligai Bai*, Fabrication of a lignin-dopped monolithic adsorbent and its properties for the extraction of hyperin from Senecionis Scandentis Hebra, Microchemical Journal, 181 (2022). DOI: 10.1016/j.microc.2022.107831
9. Fanrong Sun, Ligai Bai*, Mingxue Li, Changqing Yu, Haiyan Liu, Xiaoqiang Qiao and Hongyuan Yan*, Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples, Journal of Pharmaceutical Analysis, 12 (2022). DOI: 10.1016/j.jpha.2020.12.006
10. Fanrong Sun, Laisen Wang, Changqing Yu, Haiyan Liu, Hongyuan Yan and Ligai Bai*, Fabrication of a monolithic adsorbent with multi-sites and its application in the extraction of active components from traditional Chinese medicine formula, Microchemical Journal,169 ( 2021). DOI: 10.1016/j.microc.2021.106591

*以上信息由高级会员个人更新和维护。