王黎明

男， 中国科学院高能物理研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999-2003，四川大学，生物学，本科
2004-2007，四川大学，生物学，硕士
2007-2011，国家纳米科学中心，物理化学，博士
2011-今，中国科学院高能物理研究所，助理研究员、副研究员、特聘青年研究员

研究领域和兴趣

纳米毒理学分析，同步辐射分析，核分析技术，纳米毒理学，纳米医学

主要业绩

主要围绕纳米材料/纳米药物与生物体跨尺度相互作用的创新分析方法开展研究；基于纳米-生物体（分子、细胞、组织脏器、个体）的多层次相互作用的规律，精确调控生物体纳米材料的行为与过程，推动纳米医学的应用。具体研究方向: 1）基于同步辐射、中子、质谱，开发金属纳米药物与生物体多层级相互作用的分析方法；在纳米-生物分子作用动态过程与界面结构分析、原位化学分析、单细胞/单颗粒的高分辨化学成像等方面发展一系列创新方法。2）纳米药物载体/纳米材料在生物体内全周期过程的研究与精准调控。3）病原体防治、心血管疾病治疗潜力的新型纳米材料开发与应用。在Nature Nanotechnology, Nature Communications, Journal of American Chemical Society, Analytical Chemistry, ACS Nano, Nano Letters等学术期刊发表80余篇论文,被引用10000余次，H-index 47。荣获中国科学院杰出科学成就奖（2019）、中国毒理学会-联合利华毒理学替代法创新奖（2017）、中国毒理学会-英国皇家化学会优秀论文奖（2015）、国际纳米药剂学青年科学家（2012）等奖励。任中国稀土学会稀土生物医学分会委员、中国毒理学会呼吸毒理学会青年委员、中国毒理学会纳米毒理学分会青年委员、中华预防医学会卫生毒理分会青年委员。

研究方向：
1）基于大科学装置，发展创新分析方法，研究纳米药物/纳米材料与生物体全周期作用过程
2）纳米材料的生物学效应
3）纳米-生物界面调控及其在生物医学应用

代表成果

1. Guofang Zhang, Yalin Cong, Feng-Liang Liu, Jiufeng Sun, Jiantian Zhang, Guoli Cao, Lingqiang Zhou, Wenjie Yang, Qingle Song, Fangjun Wang, Ke Liu, Jing Qu, Jing Wang, Min He, Shun Feng, Didar Baimanov, Wei Xu, Rong-Hua Luo, Xin-Yan Long, Shumin Liao, Yunping Fan, Yu-Feng Li, Bai Li, Ximing Shao, Guocheng Wang, Lijing Fang, Huaiyu Wang, Xue-Feng Yu, Yan-Zhong Chang, Yuliang Zhao, Liang Li, Peng Yu, Yong-Tang Zheng,* Diana Boraschi, Hongchang Li,* Chunying Chen,* Liming Wang* & Yang Li.* A Nanomaterial Targeting the Spike Protein Captures SARS-CoV-2 Variants and Promotes Viral Elimination. Nature Nanotechnology 2022, 17 (9), 993-1003.

2. Didar Baimanov, Jing Wang, Ke Liu, Yalin Cong, Yunlong Zhou,* Liming Wang,* Chungying Chen.* In situ Analysis of Nanoparticle Soft Corona and Dynamic Evolution. Nature Communications 2022, 13, 5389.

3. Saima Hameed, Didar Baimanov, Xiumin Li, Ke Liu, Liming Wang*.Synchrotron Radiation-based Analysis of Interactions at the Nano–bio Interface. Environmental Science: Nano 2022, 9, 3152-3167.

4. Haiyun Li, Jiao Yan, Dejing Meng, Rui Cai, Xingshuang Gao, Yinglu Ji, Liming Wang,* Chunying Chen,* Xiaochun Wu.* Gold Nanorod-Based Nanoplatform Catalyzes Constant NO Generation and Protects from Cardiovascular Injury. ACS Nano 2020, 14 (10), 12854-12865.

5. Didar Baimanov, Junguang Wu, Runxuan Chu, Rong Cai, Bing Wang, Mingjing Cao, Ye Tao, Jiaming Liu, Mengyu Guo, Jing Wang, Xia Yuan, Chengdong Ji, Yuliang Zhao, Weiyue Feng,* Liming Wang,* Chunying Chen.* Immunological Responses Induced by Blood Protein Coronas on Two-Dimensional MoS2 Nanosheets. ACS Nano 2020, 14 (5), 5529-5542.

6. Jie Ding, Yong Guan, Yalin Cong, Liang Chen, Yu-Feng Li, Lijuan Zhang, Lili Zhang, Jian Wang, Ru Bai, Yuliang Zhao, Chunying Chen, and Liming Wang.* Single-Particle Analysis for Structure and Iron Chemistry of Atmospheric Particulate Matter. Anal. Chem. 2020, 92(1): 975-982.

7. Yanlin Feng, Guorui Wang, Yun Chang, Yan Cheng, Bingbing Sun, Liming Wang,* Chunying Chen, Haiyuan Zhang.* Electron Compensation Effect Suppressed Silver Ion Release and Contributed Safety of Au@ Ag Core–Shell Nanoparticles. Nano Lett. 2019, 19 (7), 4478-4489.

8. Liming Wang, Peiyu Quan, Serena H. Chen, Wei Bu, Yufeng Li, Xiaochun Wu, Junguang Wu, Leilei Zhang, Yuliang Zhao, Xiaoming Jiang, Binhua Lin,* Ruhong Zhou,* Chunying Chen.* Stability of Ligands on Nanoparticles Regulating the Integrity of Biological Membranes at the Nano–Lipid Interface. ACS Nano 2019,13 (8), 8680-8693.

9. Liming Wang, Liang Yan, Jing Liu, Chunying Chen*, Yuliang Zhao*. Quantification of Nanomaterial/Nanomedicine Trafficking in vivo. Anal. Chem. 2018, 90 (1), 589-614.

10. Liming Wang, Tianlu Zhang, Panyun Li, Wanxia Huang, Jinglong Tang, Pengyang Wang, Jing Liu, Qingxi Yuan, Ru Bai, Kai Zhang, Yuliang Zhao, Chunying Chen. Use of Synchrotron Radiation-Analytical Techniques to Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity. ACS Nano 2015, 9: 6532-6547.

11. Liming Wang, Qiang Sun, Xin Wang, Tao Wen, Junjie Yin, Pengyang Wang, Ru Bai, Xiang-Qian Zhang, Lu-Hua Zhang, An-Hui Lu*, Chunying Chen*. Using Hollow Carbon Nanospheres as a Light-induced Free Radical Generator to Overcome Chemotherapy Resistance. J. Am. Chem. Soc. 2015, 137: 1947–1955.

12. Liming Wang, Jingyuan Li, Jun Pan, Xiumei Jiang, Yinglu Ji, Yufeng Li, Ying Qu, Yuliang Zhao, Xiaochun Wu*, Chunying Chen*. Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes. J. Am. Chem. Soc. 2013, 135: 17359-17368.

13. Liming Wang, Ying Liu, Wei Li, Xiumei Jiang, Yinglu Ji, Xiaochun Wu*, Ligeng Xu, Yang Qiu, Kai Zhao, Taotao Wei, Yufeng Li, Yuliang Zhao, Chunying Chen*. Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy. Nano Lett. 2011, 11, 772-780. 　

*以上信息由高级会员个人更新和维护。