霍小红

男， 上海交通大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2010.09-2012.08 上海交通大学，有机化学，硕士（导师：张万斌 讲席教授）
2013.07-2013.10 Tohoku University，理学院（联合导师：Prof. Ilya D. Gridnev and Prof. Masahiro Terada）
2012.09-2017.02 上海交通大学，药学，博士（导师：张万斌 讲席教授 刘燕刚教授）
2017.03-2019.04 上海交通大学，博士后（合作导师：张万斌 讲席教授）
2019.05-2023.07 上海交通大学化学化工学院，长聘教轨副教授，博士生导师
2023.08-至今 上海交通大学化学化工学院，教授，博士生导师

研究领域和兴趣

1）双金属协同催化; 2）重要手性药物的高效不对称合成; 3) 机理研究包括实验与高斯计算

主要业绩

长期致力于双金属协同催化体系的开发并用于含两个手性中心分子的立体发散性合成研究。迄今，共发表Science、J. Am. Chem. Soc.、Angew. Chem.和CCS Chem. 等40余篇。研究论文被中国科学报、Synfacts 、Organic Chemistry Portal 、J. Am. Chem. Soc.、Org. Process Res. Dev.和Chin. J. Org. Chem.等亮点介绍；并应邀参与了2本英文专著（章）SOS Reference Library: Dual Catalysis in Organic Synthesis 等的编写工作。先后获得国家“万人计划”青年拔尖人才、国家自然科学奖二等奖（排名第3）、上海市自然科学奖一等奖（排名第3）、上海市青年五四奖章（个人）、上海市青年科技英才“扬帆计划”、上海交通大学优秀博士学位论文奖、上海交通大学首届学术之星和美国化学会上海分会研究生学术成就奖等荣誉奖励。

代表成果

Panpan Li, En Zheng, Guanlin Li, Yicong Luo, Xiaohong Huo, Shengming Ma,* and Wanbin Zhang*, Stereodivergent access to non-natural α-amino acids via enantio- and Z/E-selective catalysis, Science 2024, 385, 972-979. DOI: 10.1126/science.ado4936.

Wenzhi Zhu, Chongyu Han, Guoqiang Yang, Xiaohong Huo*, and Wanbin Zhang*, Pd/Cu-Cocatalyzed Enantio- and Diastereodivergent Wacker-Type Dicarbofunctionalization of Unactivated Alkenes. J. Am. Chem. Soc. 2024, 146, accepted. DOI: 10.1021/jacs.4c06788.

Jiacheng Zhang, Yicong Luo, En Zheng, Xiaohong Huo, Shengming Ma* and Wanbin Zhang*, Synergistic Pd/Cu-Catalyzed 1,5-Double Chiral Inductions. J. Am. Chem. Soc. 2024, 146, 9241–9251. DOI: 10.1021/jacs.4c00497.

Panpan Li, Zijiao Liu, Xiaohong Huo*, and Wanbin Zhang*, Stereodivergent Construction of 1,5/1,7-Nonadjacent Tetrasubstituted Stereocenters Enabled by Pd/Cu-Cocatalyzed Asymmetric Heck Cascade Reaction. Angew. Chem. Int. Ed. 2024, 63, e202407498. DOI: 10.1002/anie.202407498.

Youbin Peng, Guanlin Li, Chongyu Han, Yicong Luo, Xiaohong Huo*, and Wanbin Zhang*, Stereodivergent Benzylic Substitution of Racemic Secondary Benzyl Esters Enabled by Pd/Cu Dual Catalysis. CCS Chem. 2024, accepted. DOI: 10.31635/ccschem.024.202303749.

Yicong Luo, Yuqi Ma, Guanlin Li, Xiaohong Huo*, and Wanbin Zhang*, Desymmetrization of Geminal Difluoromethylenes using a Palladium/Copper/Lithium Ternary System for the Stereodivergent Synthesis of Fluorinated Amino Acids. Angew. Chem. Int. Ed. 2023, 62, e202313838. DOI: 10.1002/anie.202313838.
(Hot Paper; Highlighted by SYNFACTS 2024, 20, 0100)

Ling Zhao, Yicong Luo, Junzhe Xiao, Xiaohong Huo, Shengming Ma, and Wanbin Zhang*, Stereodivergent Synthesis of Allenes with α,β-Adjacent Central Chiralities Empowered by Synergistic Pd/Cu Catalysis. Angew. Chem. Int. Ed. 2023, 62, e202218146. DOI: 10.1002/anie.202218146.
(Hot Paper)

Xiaohong Huo, Guanlin Li, Xi Wang, and Wanbin Zhang*, Bimetallic Catalysis in Stereodivergent Synthesis. Angew. Chem. Int. Ed. 2022, 61, .

Youbin Peng, Chongyu Han, Yicong Luo, Guanlin Li, Xiaohong Huo, and Wanbin Zhang*, Nickel/Copper-Cocatalyzed Asymmetric Benzylation of Aldimine Esters for the Enantioselective Synthesis of α-Quaternary Amino Acids. Angew. Chem. Int. Ed. 2022, 61, e202203448. DOI: 10.1002/anie.202203448
(Hot Paper; Highlighted by SYNFACTS 2022, 18, 0816)

Jiacheng Zhang,§ Xiaohong Huo,§ Junzhe Xiao,§ Ling Zhao, Shengming Ma*, and Wanbin Zhang*, Enantio- and Diastereodivergent Construction of 1,3-Nonadjacent Stereocenters Bearing Axial and Central Chirality through Synergistic Pd/Cu Catalysis. J. Am. Chem. Soc. 2021, 143(32), 12622-12632. DOI: 10.1021/jacs.1c05087
(§co-first author)

Youbin Peng,§ Xiaohong Huo § Yicong Luo, Liang Wu, and Wanbin Zhang*, Enantio- and Diastereodivergent Synthesis of Spirocycles through Dual-Metal-Catalyzed [3+2] Annulation of 2-Vinyloxiranes with Nucleophilic Dipoles. Angew. Chem. Int. Ed. 2021, 60(47), 24941-24949. DOI: 10.1002/anie.202111842
(Hot Paper; Highlighted by SYNFACTS 2021, 17, 1352; §co-first author)

Xiaohong Huo, Ling Zhao, Yicong Luo, Yue Wu, Yuwen Sun, Guanlin Li, Tatiana Gridneva, Jiacheng Zhang, Yong Ye, and Wanbin Zhang*, Stereodivergent Pd/Cu Catalysis for Asymmetric Desymmetric Alkylation of Allylic Geminal Dicarboxylates. CCS Chem. 2021, 3, 1933-1944.
DOI: 10.31635/ccschem.021.202101044

Ling Zhao, Guanlin Li, Rui He, Penglin Liu, Feijun Wang, Xiaohong Huo*, Min Zhao*, and Wanbin Zhang*, Stereodivergent Pd/Cu Catalysis: Asymmetric Alkylation of Racemic Symmetrical 1,3-Diphenyl Allyl Acetates. Org. Biomol. Chem. 2021, 19(9), 1955-1959. DOI: 10.1039/d0ob02499f
(Invited Paper for Hybrid Catalysis; Highlighted by SYNFACTS 2021, 17, 586)

Rui He,§ Xiaohong Huo,§ Ling Zhao, Feijun Wang, Liyin Jiang, Jian Liao*, and Wanbin Zhang*, Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates. J. Am. Chem. Soc. 2020, 142(18), 8097-8103. DOI: 10.1021/jacs.0c02150
(Highlighted by 有机化学 2020, 40, 2161; §co-first author)

Mo Wang,§ Lu Zhang,§ Xiaohong Huo,§ Zhenfeng Zhang,§ Qianjia Yuan, Panpan Li, Jianzhong Chen, Yashi Zou, Zhengxing Wu, and Wanbin Zhang*, Catalytic Asymmetric Synthesis of the anti-COVID-19 Drug Remdesivir. Angew. Chem. Int. Ed. 2020, 59(47), 20814-20819. DOI: 10.1002/anie.202011527
(Highlighted by SYNFACTS 2020, 16, 1350; Very Important Paper; Frontispiece; 入选第二届上海交通大学十大科技进展; §co-first author)

Guanlin Li,§ Xiaohong Huo,§ Xieyang Jiang, and Wanbin Zhang*, Asymmetric Synthesis of Allylic Compounds via Hydrofunctionalisation and Difunctionalisation of Dienes, Allenes, and Alkynes. Chem. Soc. Rev. 2020, 49(7), 2060-2118. DOI: 10.1039/c9cs00400a

Xiaohong Huo, Jiacheng Zhang, Jingke Fu, Rui He, and Wanbin Zhang*, Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters. J. Am. Chem. Soc. 2018, 140(6), 2080-2084. DOI: 10.1021/jacs.8b00187
(Highlighted by Organic Chemistry Portal; ESI Highly Cited Paper)

Xiaohong Huo, Rui He, Jingke Fu, Jiacheng Zhang, Guoqiang Yang, and Wanbin Zhang*, Stereoselective and Site-Specific Allylic Alkylation of Amino Acids and Small Peptides via a Pd/Cu Dual Catalysis. J. Am. Chem. Soc. 2017, 139(29), 9819-9822. DOI: 10.1021/jacs.7b05460

Xiaohong Huo,§ Rui He,§ Xiao Zhang, and Wanbin Zhang*, An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones. J. Am. Chem. Soc. 2016, 138(35), 11093-11096. DOI: 10.1021/jacs.6b06156
(Highlighted by SYNFACTS 2016, 12, 1153 and selected as Front Cover and Synfact of the month; Highlighted by Org. Process. Res. Dev. 2016, 20, 1691; §co-first author)

Xiaohong Huo, Guoqiang Yang, Delong Liu, Yangang Liu, Ilya D. Gridnev*, and Wanbin Zhang*, Palladium-Catalyzed Allylic Alkylation of Simple Ketones with Allylic Alcohols and Its Mechanistic Study. Angew. Chem. Int. Ed. 2014, 53(26), 6776-6780. DOI: 10.1002/anie.201403410

*以上信息由高级会员个人更新和维护。