陈志敏

男， 上海交通大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2005.9-2009.6 福州大学，理学学士，专业：化学（国家理科化学基地班）

2009.9-2014.6 兰州大学，理学博士，专业：有机化学，导师：涂永强院士

2014.07-2017.11 上海交通大学，博士后，导师：涂永强院士

2015.07-2017.08 美国犹他大学，博士后，导师：Prof. Matthew S. Sigman

2017.12-2024.06 上海交通大学化学化工学院，长聘教轨副教授、长聘副教授，博士生导师

2024.07 -至今 上海交通大学化学化工学院，教授，博士生导师

研究领域和兴趣

有机合成

主要业绩

申请人自2018年独立开展工作以来，一直聚焦手性硫化学和硒化学研究，以高效精准构筑结构多样的手性含硫/硒化合物为研究目标。申请人通过设计合成基于BINOL和 SPINOL骨架的两类新型手性路易斯碱催化剂和基于糖精骨架的单硫和双硫试剂，发展手性路易斯碱和（手性）布朗斯特酸的不对称协同催化策略，为含中心手性、轴手性、平面手性、螺旋手性和固有手性的有机硫/硒化合物提供了高效精准的合成方法。同时，应用这些方法，申请人完成了天然产物(-)-herbertene、(-)-nicotlatone B、(-)-galbacin和 (+)-ricciocarpin A的简洁不对称合成。申请人以（共同）通讯作者发表论文39篇，包括J. Am. Chem. Soc. 1篇，Angew. Chem. Int. Ed. 5篇，Nat. Commun. 2篇，CCS Chem. 1篇，ACS Catal. 1篇，Sci. China Chem. 1篇等。同时，获国家发明专利授权6项。发表的论文总他引 2800余次，相关研究成果被Synfacts等作为亮点工作进行正面报道、评述，并被收录于《Organocatalytic Sigmatropic Reactions》等多部著作中。申请人也获得教育部“长江学者奖励计划” 青年学者和上海市高校特聘教授（东方学者）等荣誉称号。

代表成果

1. Yu-Xuan Huo, Ren-Fei Cao, Jie Huang, Ze-Long Li, Zheng-Wei Wei, Deng Zhu, Zhi-Min Chen*. N-(Acyldithio)saccharin: Design, Synthesis and Applications in Catalytic Enantioselective Disulfuration/Amination of Alkenes. Angew. Chem. Int. Ed. 2025, 64, e202503815.

2. Ren-Fei Cao+, Ruirui Su+, Zheng-Wei Wei, Ze-Long Li, Deng Zhu, Yu-Xuan Huo, Xiao-Song Xue*, Zhi-Min Chen*. Chiral Sulfide and Achiral Sulfonic Acid Cocatalyzed Enantioselective Electrophilic Tandem Selenylation Semipinacol Rearrangement of Allenols. Nat. Commun. 2025, 16, 2147.

3. Xin-Yu Zhang+, Deng Zhu+, Ren-Fei Cao, Yu-Xuan Huo, Tong-Mei Ding, Zhi-Min Chen*. Enantioselective Synthesis of Inherently Chiral Sulfur-Containing Calix[4]arenes via Chiral Sulfide Catalyzed Desymmetrizing Aromatic Sulfenylation. Nat. Commun. 2024, 15, 9929.

4. Deng Zhu, Tong Mu, Ze-Long Li, Hui-Yun Luo, Ren-Fei Cao, Xiao-Song Xue*, Zhi-Min Chen*. Enantioselective Synthesis of Planar-Chiral Sulfur-Containing Cyclophanes by Chiral Sulfide Catalyzed Electrophilic Sulfenylation of Arenes. Angew. Chem. Int. Ed. 2024, 63, e202318625.

5. Deng Zhu+, Lu Yu+, Hui-Yun Luo, Xiao-Song Xue*, Zhi-Min Chen*. Atroposelective Electrophilic Sulfenylation of N-Aryl Aminoquinone Derivatives Catalyzed by Chiral SPINOL-Derived Sulfide. Angew. Chem. Int. Ed. 2022, 61, e202211782.


6. Hui-Yun Luo, Zi-Hao Li, Deng Zhu, Qin Yang, Ren-Fei Cao, Tong-Mei Ding, Zhi-Min Chen*. Chiral Selenide/Achiral Sulfonic Acid Co-catalyzed Atroposelective Sulfenylation of Biaryl Phenols via a Desymmetrization/Kinetic Resolution Sequence. J. Am. Chem. Soc. 2022, 144, 2943-2952.

7. Xiao-Dong Liu+, Yicong Luo+, Xiaohong, Huo, Hui-Yun Luo, Ren-Fei Cao, Zhi-Min Chen*. Chiral Sulfide/Phosphoric Acid Cocatalyzed Enantioselective Intermolecular Oxysulfenylation of Alkenes with Phenol and Alcohol O-nucleophiles. CCS Chem., 2022, 4, 3342-3354.

8. Xiao-Dong Liu, Ai-Hui Ye, Zhi-Min Chen*. Catalytic Enantioselective Intermolecular Three-Component Sulfenylative Difunctionalizations of 1,3-Dienes. ACS Catal. 2023, 13, 2715-2722.

9. Yu-Yang Xie, Zhi-Min Chen,* Hui-Yun Luo, Hui Shao, Yong-Qiang Tu,* Xiaoguang Bao,* Ren-Fei Cao, Shu-Yu Zhang, Jin-Miao Tian. Lewis Base/Brønsted Acid Cocatalyzed Enantioselective Sulfenylation/Semipinacol Rearrangement of Di- and Trisubstituted Allylic Alcohols. Angew. Chem. Int. Ed. 2019, 58, 12491-12496.

10. Jia‐Wei Dong, Tongmei Ding, Shu‐Yu Zhang*, Zhi‐Min Chen*, Yong‐Qiang Tu*. A Facile Approach to Oximes and Ethers by a Tandem NO+‐Initiated Semipinacol Rearrangement and H‐Elimination. Angew. Chem. Int. Ed. 2018, 57, 13192-13196.

*以上信息由高级会员个人更新和维护。