陈志敏

男， 上海交通大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2005.9-2009.6 福州大学，理学学士，专业：化学（国家理科化学基地班）
2009.9-2014.6 兰州大学，理学博士，专业：有机化学，导师：涂永强院士
2014.07-2017.11 上海交通大学，博士后，导师：涂永强院士
2015.07-2017.08 美国犹他大学，博士后，导师：Prof. Matthew S. Sigman
2017.12-2024.06 上海交通大学化学化工学院，长聘教轨副教授、长聘副教授，博士生导师
2024.07 -至今 上海交通大学化学化工学院，教授，博士生导师

研究领域和兴趣

有机合成、不对称催化、有机硫属元素化学、药物分子合成

主要业绩

本人自2018年独立开展工作以来，一直聚焦手性硫化学和硒化学研究，以高效精准构筑结构多样的手性含硫/硒化合物为研究目标。近年来，本人通过设计合成基于BINOL和 SPINOL骨架的两类新型手性路易斯碱催化剂和基于糖精骨架的单硫、二硫和硒试剂，发展手性路易斯碱和（手性）布朗斯特酸的不对称协同催化策略，为含中心手性、轴手性、平面手性、螺旋手性和固有手性的有机硫/硒化合物提供了高效精准的合成方法。同时，应用这些方法，申请人完成了天然产物(-)-herbertene、(-)-nicotlatone B、(-)-galbacin和 (+)-ricciocarpin A的简洁不对称合成。基于上述研究成果，本人以通讯/共同通讯作者发表论文39篇，包括J. Am. Chem. Soc. 1篇，Angew. Chem. Int. Ed. 6篇，Nat. Commun. 2篇，CCS Chem. 1篇，ACS Catal. 1篇，Sci. China Chem. 1篇等。同时，获国家发明专利授权6项。发表的论文总他引 2800余次，相关研究成果被Synfacts等作为亮点工作进行正面报道、评述，并被收录于《Organocatalytic Sigmatropic Reactions》等多部著作中。本人也获得国家级高层次优秀青年人才和上海市高校特聘教授（东方学者）等荣誉称号。

代表成果

1. Ze-Long Li, Yu-Xuan Huo, Qi-Sen Gao, Tong-Mei Ding, Zhi-Min Chen*. Dynamic Kinetic Resolution Approach to Chiral Sulfur-Containing Aza-[5]helicenes via Chiral Lewis Base Catalyzed C-H Sulfenylation. Angew. Chem. Int. Ed. 2025, 64, e202515017.

2. Yu-Xuan Huo, Ren-Fei Cao, Jie Huang, Ze-Long Li, Zheng-Wei Wei, Deng Zhu, Zhi-Min Chen*. N-(Acyldithio)saccharin: Design, Synthesis and Applications in Catalytic Enantioselective Disulfuration/Amination of Alkenes. Angew. Chem. Int. Ed. 2025, 64, e202503815.

3. Ren-Fei Cao+, Ruirui Su+, Zheng-Wei Wei, Ze-Long Li, Deng Zhu, Yu-Xuan Huo, Xiao-Song Xue*, Zhi-Min Chen*. Chiral Sulfide and Achiral Sulfonic Acid Cocatalyzed Enantioselective Electrophilic Tandem Selenylation Semipinacol Rearrangement of Allenols. Nat. Commun. 2025, 16, 2147.

4. Xin-Yu Zhang+, Deng Zhu+, Ren-Fei Cao, Yu-Xuan Huo, Tong-Mei Ding, Zhi-Min Chen*. Enantioselective Synthesis of Inherently Chiral Sulfur-Containing Calix[4]arenes via Chiral Sulfide Catalyzed Desymmetrizing Aromatic Sulfenylation. Nat. Commun. 2024, 15, 9929.

5. Deng Zhu, Tong Mu, Ze-Long Li, Hui-Yun Luo, Ren-Fei Cao, Xiao-Song Xue*, Zhi-Min Chen*. Enantioselective Synthesis of Planar-Chiral Sulfur-Containing Cyclophanes by Chiral Sulfide Catalyzed Electrophilic Sulfenylation of Arenes. Angew. Chem. Int. Ed. 2024, 63, e202318625.

6. Deng Zhu+, Lu Yu+, Hui-Yun Luo, Xiao-Song Xue*, Zhi-Min Chen*. Atroposelective Electrophilic Sulfenylation of N-Aryl Aminoquinone Derivatives Catalyzed by Chiral SPINOL-Derived Sulfide. Angew. Chem. Int. Ed. 2022, 61, e202211782.

7. Hui-Yun Luo, Zi-Hao Li, Deng Zhu, Qin Yang, Ren-Fei Cao, Tong-Mei Ding, Zhi-Min Chen*. Chiral Selenide/Achiral Sulfonic Acid Co-catalyzed Atroposelective Sulfenylation of Biaryl Phenols via a Desymmetrization/Kinetic Resolution Sequence. J. Am. Chem. Soc. 2022, 144, 2943-2952.

8. Xiao-Dong Liu+, Yicong Luo+, Xiaohong, Huo, Hui-Yun Luo, Ren-Fei Cao, Zhi-Min Chen*. Chiral Sulfide/Phosphoric Acid Cocatalyzed Enantioselective Intermolecular Oxysulfenylation of Alkenes with Phenol and Alcohol O-nucleophiles. CCS Chem., 2022, 4, 3342-3354.

9. Yu-Yang Xie, Zhi-Min Chen,* Hui-Yun Luo, Hui Shao, Yong-Qiang Tu,* Xiaoguang Bao,* Ren-Fei Cao, Shu-Yu Zhang, Jin-Miao Tian. Lewis Base/Brønsted Acid Cocatalyzed Enantioselective Sulfenylation/Semipinacol Rearrangement of Di- and Trisubstituted Allylic Alcohols. Angew. Chem. Int. Ed. 2019, 58, 12491-12496.

10. Jia‐Wei Dong, Tongmei Ding, Shu‐Yu Zhang*, Zhi‐Min Chen*, Yong‐Qiang Tu*. A Facile Approach to Oximes and Ethers by a Tandem NO+‐Initiated Semipinacol Rearrangement and H‐Elimination. Angew. Chem. Int. Ed. 2018, 57, 13192-13196.

*以上信息由高级会员个人更新和维护。