吕华

男， 北京大学化学与分子工程学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2024/12 – 北京大学化学与分子工程学院学术委员会委员
2025/04 – 北京大学高分子化学与物理教育部重点实验室主任
2022/02 – 教授，北京大学化学与分子工程学院
2020/04 – Biomacromolecules，Associate Editor
2020/02 – 2022/01 副教授（长聘），北京大学化学与分子工程学院
2014/02 – 2020/01 助理教授，北京大学化学与分子工程学院
2011/07 – 2014/05 博士后， 斯克里普斯（Scripps）研究所化学系
2006/08 – 2011/05 博士, 美国伊利诺伊大学香槟分校（UIUC）材料系
2002/09 – 2006/07 学士，北京大学化学与分子工程学院

研究领域和兴趣

高分子化学与物理，生物医用高分子材料

主要业绩

申请人聚焦氨基酸可降解高分子的可控构筑与高效蛋白质偶联，设计合成基于氨基酸的新单体与可降解聚合物，发展聚合引发剂，高效精准地合成蛋白-可降解高分子偶联物并探究其构效关系与应用，取得学术成绩如下：1. 以天然氨基酸为原料，基于合理的分子设计，可控合成了多种高度动态、刺激响应及抗生物污染的功能聚氨基酸与聚(硫)酯，为高端生物材料与蛋白质偶联奠定了丰富的分子库，为发展环境友好高分子提供了设计理念。2. 提出并发展了多种简洁的聚合物原位官能团化与原位生长策略，实现了蛋白质与可降解高分子的高效定点偶联，解决了传统方法合成效率低，步骤繁琐，结构不均一、分离困难等问题。3. 在精准控制蛋白质-聚氨基酸偶联物结构的基础上，发现并探究了偶联物大环拓扑结构与聚氨基酸螺旋结构的活体药学效应，填补了相关构效关系研究的空白，发展了长效、低免疫原、具有一定转化潜力的蛋白质药物，为药物蛋白的高分子改性提供了全新的视角并奠定了材料基础。
近5年以北京大学为第一单位在Chem, JACS (×4), ACS Cent. Sci., CCS Chem.等发表（共同）通讯作者论文32篇；获JACS封面论文、ACS Editors’ Choice、C&EN、Spotlight on recent JACS publications、《高分子学报》亮点评述。曾获中组部青年人才引进计划（2015）、基金委优秀青年科学基金（2017）、中国化学会青年化学奖（2017）、中国化学会高分子青年学者奖（2019），中国青年化学家元素周期表代言人，代言元素氮 （2019）、ACS PMSE Young Investigator Symposium（2020）, 日本高分子学会（SPSJ）Invited Lecturer of International Leading Young Scientist（2020）；承担基金委与科技部等项目共计8项；获阿斯利康等药企转化基金共计3项；担任ACS期刊Biomacromolecules副主编；作为分论坛主席组织2017太平洋高分子会议（PPC）与2017美国化学会秋季年会，作为高登学术会议的讨论主持人（Gordon Research Conferences discussion leader）1次，重要会议做邀请或主旨报告30余次。

代表成果

近五年代表作：
[1] Haolin Chen,† Haisen Zhou*,†, Tianyi Jin, Zhihui Zhang, Zhenzhong Zhao, Haoran Cai, Xiaoman Yu, Hong Liu, Shi Chen, Chuang Li, Xuehai Yan, Guangqi Wu, Miao Qi, Lixin Liu,* Yongming Chen* and Hua Lu* “Random Hybrid Polypeptides Regulate Immune Signaling through Promiscuous and Dynamic Interaction Landscapes”, J. Am. Chem. Soc. 2026, 148, 45193–45206. (†equal contribution)
[2] Mingyuan Lu, Zhen Zhu, Shuo Wang, Letian Wang, Haoyu Yang, Zhengqi Yang, Lijiang Yang, Yi Qin Gao, and Hua Lu* “Polymerization Chaperone for the Controlled, Homogeneous Synthesis of Proline-Based Homo- and Copolypeptides”, J. Am. Chem. Soc. 2026, 148, 12033–12043.
[3] Chun-Yan Lyu,† Wei Xia,† Tianyi Ma,† Chaoqun Weng, Ming-He Sun, Bai-Yu Wu, Xiaoyan Tang, Guoming Liu,* Hua Lu,* and Er-Qiang Chen*, “A Recyclable Polythioester With α-Gem-Dimethyl Substitution: Instantaneous Crystallization Triggered by Large and Rapid Stretching”, Adv. Mater. 2026, 38, e21662. (†equal contribution)
[4] Letian Wang, Wencan Wang, Xinyi Zhu, Chenming Tang, Xiaodong Jing, Yahui He, Justin Amengual, Yao Lin, Zhixiang Yu* and Hua Lu* “Ring-Opening Polymerization of Unprotected Hydroxyproline N-Carboxyanhydride for the Facile Synthesis of Linear and Branched Poly-l-hydroxyproline”, CCS Chem. 2025, 7, 3807-3822.
[5] Haisen Zhou,† Guangqi Wu*,†, Zuo Zhang,† Zhen Zhu, Tanfeng Zhao, Qiankang Zhou, Haolin Chen, Zhenzhong Zhao, Yuanhao Dai, Xiaodong Jing, Wei Ji, Xuehai Yan, Lijiang Yang, Yiqin Gao, Huan Wang*, Hua Lu* “Data-driven Design of Random Heteropolypeptides as Synthetic Polyclonal Antibodies”, J. Am. Chem. Soc. 2025, 147, 21077–21088. (†equal contribution)
[6] Ruichi Zhao,† Yangming Zhang,† Banlai Ruan, Hairuo Zhang, Niannian Lv, Jiayi Li, Yuhe R. Yang*, Xiaozhou Luo*, Hua Lu* “Nanourchin-like Uricase-Poly(L-proline) Conjugate with Retained Enzymatic Activity, Mitigated Immunogenicity, and Sustained Efficacy Upon Repeated Administrations”, Angew. Chem. Int. Ed. 2025, 64, e202425559. (†equal contribution)
[7] Shuo Wang, Zi-You Tian, and Hua Lu*, “Recyclable Polythioesters and Poly(thioester-co-peptoid)svia Ring-Opening Cascade Polymerization of Amino Acid N-Carboxyanhydrides”, Angew. Chem. Int. Ed. 2024, 63, e202411630.
[8] Shuo Wang, Ming-Yuan Lu, Si-Kang Wan, Chun-Yan Lyu, Zi-You Tian, Kai Liu, and Hua Lu*, “Precision Synthesis of Polysarcosine via Controlled Ring-Opening Polymerization of N-Carboxyanhydride: Fast Kinetics, Ultrahigh Molecular Weight, and Mechanistic Insights”, J. Am. Chem. Soc. 2024, 146, 5678–5692.
[9] Jianhua Lu, Yuanhao Dai, Yahui He, Ting Zhang, Jing Zhang, Xiangmei Chen, Changtao Jiang, and Hua Lu*, “Organ/Cell-Selective Intracellular Delivery of Biologics via N-Acetylated Galactosamine-Functionalized Polydisulfide Conjugates”, J. Am. Chem. Soc. 2024, 146, 3974–3983.
[10] Guangqi Wu, Haisen Zhou, Jun Zhang, Zi-You Tian, Xingyi Liu, Shuo Wang, Connor W. Coley, and Hua Lu*, “A High-Throughput Platform for Efficient Exploration of Functional Polypeptide Chemical Space”, Nat. Synth. 2023, 2, 515-526.
[11] Jianhua Lu, Zhun Xu, Hailin Fu, Yao Lin, Huan Wang, and Hua Lu*, “Room-Temperature Grafting from Synthesis of Protein–Polydisulfide Conjugates via Aggregation-Induced Polymerization”, J. Am. Chem. Soc. 2022, 144, 15709-15717.
[12] Yali Hu, Zi-You Tian, Wei Xiong, Dedao Wang, Ruichi Zhao, Yan Xie, Yu-Qin Song, Jun Zhu, Hua Lu*, “Water-Assisted and Protein-Initiated Fast and Controlled Ring-Opening Polymerization of Proline N-Carboxyanhydride”, Natl. Sci. Rev. 2022, 9, nwac033.
[13] Chao Dong,† Guangqi Wu,† Chen Chen, Xia Li, Rui Yuan, Liang Xu, Hui Guo, Jay Zhang, Hua Lu*, and Feng Wang*, “Site-specific Conjugation of a Selenopolypeptide to Alpha-1-antitrypsin Enhances Oxidation Resistance and Pharmacological Properties”, Angew. Chem. Int. Ed. 2022, 61, e202115241. (†equal contribution) (Hot Paper)
[14] Zi-You Tian, Zhengchu Zhang, Shuo Wang, and Hua Lu*, “A Moisture-Tolerant Route to Unprotected α/β-Amino Acid N-Carboxyanhydrides and Facile Synthesis of Hyperbranched Polypeptides”, Nat. Commun. 2021, 12, 5810.

*以上信息由高级会员个人更新和维护。