张竹青

女， 中国科学院大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1995.9－2000.7 北京化工大学 材料科学与工程学院 工学学士
2000.9－2005.7 中国科学院化学研究所 高分子物理与化学实验室 理学博士
2005.7－2007.11 北京大学 化学与分子工程学院，理论生物中心，博士后
2008.1－2011.5 加拿大多伦多大学 医学院生物化学系，博士后
2011.6－现在 中国科学院大学 生命科学学院，副教授、教授

研究领域和兴趣

生物大分子的理论计算

主要业绩

主要基于生物大分子的物理化学性质，通过理论与计算机模拟手段， 研究蛋白质聚集、折叠及别构机制，以及无序蛋白质的系综表征及翻译后修饰对结构及功能的影响。近年来在生物大分子液-液相分离方面进行了数据库的构建、预测及形成机制的理论及模拟研究。研究成果发表在Proc Natl Acad Sci U S A、Phys Chem Chem Phys、Bioinformatics及Nucleic Acids Res等期刊。

代表成果

1. Zhuqing Zhang, Hao Chen, Hongjun Bai, Luhua Lai*. Molecular dynamics simulations on the oligomer formation process of the GNNQQNY peptide from yeast prion protein Sup35. Biophys J. 2007,93;1484-1492
2. Zhuqing Zhang, Hao Chen, Luhua Lai*. Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential. Bioinformatics. 2007,23:2218-2225
3. Zhuqing Zhang, and Hue Sun Chan*. Competition between Native Topology and Nonnative Interactions in Simple and Complex Folding Kinetics of Natural and Designed Proteins. Proc Natl Acad Sci U S A. 2010,107:2920-2925
4. Hue Sun Chan*, Zhuqing Zhang, Stefan Wallin and Zhirong Liu. Native Topology, Local-Nonlocal Coupling, and Nonnative Interactions: Principles of Protein Folding from Coarse-Grained Models. Annu Rew Phys Chem. 2011,62:301-332
5. Zhuqing Zhang, and Hue Sun Chan*. Transition paths, diffusive processes, and preequilibria of protein folding. Proc Natl Acad Sci U S A. 2012,109:20919-20924
6. Jie Hu, Tao Chen, Moye Wang, Hue Sun Chan*, Zhuqing Zhang*. A critical comparison of coarse-grained structure-based approaches and atomic models of protein folding. Phys Chem Chem Phys. 2017,19:13629-13639.
7. Yanhua Ouyang, Likun Zhao, Zhuqing Zhang*. Characterization of the structural ensembles of p53 TAD2 by molecular dynamics simulations with different force fields. Phys Chem Chem Phys. 2018;20:8676-8684.
8. Likun Zhao, Luhua Lai*, Zhuqing Zhang*. How calcium ion binding induces the conformational transition of the calmodulin N-terminal domain-an atomic level characterization. Phys Chem Chem Phys. 2019;21;19795-19804.
9. Qian Li, Xiaojun Peng, Yuanqing Li, Wenqin Tang, Jia'an Zhu, Jing Huang, Yifei Qi and Zhuqing Zhang*. LLPSDB: a database of proteins undergoing liquid–liquid phase separation in vitro. Nucleic Acids Res. 2020;48(D1):D320–D327
10. Xi Wang, Xiang Zhou, Qinglin Yan, Shaofeng Liao, Wenqin Tang, Peiyu Xu, Yangzhenyu Gao, Qian Li, Zhihui Dou, Weishan Yang, Beifang Huang, Jinhong Li, Zhuqing Zhang*. LLPSDB v2.0: an updated database of proteins undergoing liquid-liquid phase separation in vitro. Bioinformatics. 2022:38(7):2010-2014

*以上信息由高级会员个人更新和维护。