段新瑞

男， 陕西师范大学化学化工学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999-09至2003-06, 河北大学, 化学, 学士
2003-09至2006-06, 河北大学, 分析化学, 硕士, 导师: 李正平
2006-09至2007-06, 中国科学院化学研究所 王树研究员课题组 科研助理
2007-09至2010-06, 中国科学院化学研究所, 有机化学, 博士, 导师: 王树
2010-08至2013-08, 美国南卡罗来纳大学, 博士后, 导师: Qian Wang
2012-12至今，陕西师范大学 化学化工学院

研究领域和兴趣

生化分析与生物传感

主要业绩

申请人从事肿瘤活体成像与干细胞分离相关工作。利用代谢标记和磁性微球分选分别发展了肿瘤干细胞识别与神经干细胞纯化新技术，现实了肿瘤干细胞的无标志物分选与神经干细胞的快速纯化；发展了多种荧光探针分别用于点击化学标签和肿瘤标志物的细胞成像检测；针对肿瘤细胞的活体成像检测的重要性，发展了基于直接氧化共轭聚合物主链的新型化学发光纳米粒子活体成像方法，解决了此类纳米粒子中需要小分子化学发光供体，结构复杂、具有潜在泄露风险等问题；同时利用益生菌的高效肿瘤靶向策略，实现了活体肿瘤中多种标志酶的生物发光检测与肿瘤生长抑制新策略。申请人曾获得2016年陕西省青年科技新星称号。在国际知名学术杂志上发表论文50多篇，总的他引次数超过1400 次。以第一作者及通讯作者发表的SCI论文29篇，包括J. Am. Chem. Soc.论文1 篇、Chem. Sci.论文1 篇、Nat. Protoc.论文1篇、Adv. Mater.论文1篇、Anal. Chem.论文5篇、Chem. Commun. 4篇，被他人引用超过500次。主持国家自然科 学基金面上项目两项，陕西省青年科技新星项目一项。

代表成果

1. Tianjiao Meng, Wenbo Ma, Mengyue Fan, Wei Tang, and Xinrui Duan* Enhancing the Contrast of Tumor Imaging for Image-Guided Surgery Using a Tumor-Targeting Probiotic with the Continuous Expression of a Biomarker, Anal. Chem. 2022, 94, 28, 10109–10117.
2.Ziqi Zhang, Yue Cao, Qiong Yuan, Chenghui Liu, Xinrui Duan* and Yanli Tang*, Multifunctional fluorescent probe for effective visualization, inhibition, and detoxification of β-amyloid aggregation via covalent binding, Chem. Commun. 2022, 2022, 58, 3957.
3. Yiqian Ren, Yao Qiang, Beibei Zhu, Wei Tang, Xinrui Duan* and Zhengping Li*, General Strategy for Bioluminescence Sensing of Peptidase Activity In Vivo Based on Tumor-Targeting Probiotic, Anal. Chem. 2021, 93, 4334−4341.
4. Yiqian Ren, Yao Qiang, Xinrui Duan* and Zhengping Li*, The distinct difference in azido sugar metabolic rate between neural stem cells and fibroblasts and its application for decontamination of chemically induced neural stem cells, Chem. Commun., 2020, 56, 2344-2347.
5. Beibei Zhu, Wei Tang, Yiqian Ren, Xinrui Duan*, Chemiluminescence of conjugated-polymer nanoparticles by direct oxidation with hypochlorite, Anal. Chem. 2018, 90, 13714-13722.
6. Honghong Wang, Hui Wang,Xinrui Duan*,Yuanyuan Sun, Xiangdong Wang, Zhengping Li*, Highly sensitive and multiplexed quantification of mRNA splice variants by the direct ligation of DNA probes at the exon junction and universal PCR amplification, Chem. Sci. 2017, 8, 3635-3640.
7. Lingbo Sun, Hongxia Fu, Yanru Li,Xinrui Duan*; Zhengping Li*, Rapid recognition and isolation of live colon cancer stem cells by using metabolic labeling of azido sugar and magnetic beads, Anal. Chem. 2016, 88, 3953–3958.
8. Hongxia Fu, Yanru Li, Lingbo Sun, Pan He,Xinrui Duan*,Ratiometric fluorescence azide-alkyne cycloaddition for live mammalian cell imaging, Anal. Chem. 2015, 87，11332-11336.
9. Xinrui Duan, Wei Yue, Libing Liu, Zhengping Li, Yuliang Li, Fuchu He, Daoben Zhu, Gangqiao Zhou*, Shu Wang*, Single nucleotide polymorphism (SNP) genotyping using cationic conjugated polymers in homogeneous solution, Nat. Protoc. 2009, 4, 984-991.
10. Xinrui Duan, Zhengping Li*, Fang He, Shu Wang*, A sensitive and Homogeneous SNP Detection Using Cationic Conjugated Polymers, J. Am. Chem. Soc. 2007, 129, 4154-4155.

*以上信息由高级会员个人更新和维护。