席真

男， 南开大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1979-1983 华中师范大学 本科
1985-1988 南开大学 硕士
1990-1994 瑞典Uppsala 大学 博士
1994-1997 美国哈佛医学院 博士后
1997-2001 美国哈佛医学院 研究员（research associate）

研究领域和兴趣

生物活性分子的化学生物学

主要业绩

长期从事化学生物学研究，在药物抗性的分子机制与生物活性分子设计合成以及基因合成、识别、损伤及修复领域积累了丰富经验和成果。发明生物大分子定量构效关系技术（MB-QSAR，Prenzyme），建立基于靶标组结构的分子设计方法，发展比较化学基因组学用于跨种属活性分子设计以及药物抗性及选择性预测。实现了灭生性除草剂先导的设计合成，发展了除草剂-耐除草剂种子的精准配对分子设计技术。我国核酸药物领头公司-苏州瑞博（HK6938）的联合创始人，发展核酸液相合成技术以及多种核酸修饰技术，提供了小核酸药物的组织靶向性，稳定性，高效性及脱靶问题的部分解决方案，推动了我国小核酸医药产业走进国际先进行列。发明免疫激活剂环二核苷酸前药技术，实现鼻咽癌及结直肠癌模型鼠治愈，授权深圳英诺生物开展临床应用。提出并发展基因组核酸技术及基因组疗法，参与创建全合诚生物，开展基因组核酸治疗技术应用研究。率先发展作物提质增产剂新品类，与绿业元集团合作推广应用。先后主持承担十多项国家级课题，包括国家973计划，国家创新药物专项，国家科技支撑计划、国家重点研发计划，国家自然科学基金重点及面上项目。

代表成果

1.Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi. Chemically Regulated STING-Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity. Angew Chem Int Ed Eng, e8478309 (2026), DOI: 10.1002/anie.8478309.
2.Di Zhang, Liang Li, Chunxue Wang, Nuo Zhou, Zhilei Yu, Tianyi Shen, Baifan Wang, Qiang Bian, Dejun Ma, Yucheng Gu, Han Xu, Zhen Xi. A Novel Dual-Target Compound Designed With Potent Herbicidal and Fungicidal Activity Inspired by Conserved Phytoene Synthase Domains. Plant Biotechnology Journal, 24(5) (2026), DOI: 10.1111/pbi.70531.
3.Zhenghua Wang, Dejun Ma, Zhen Xi, ”CYCLIC DINUCLEOTIDES: A NEW-GENERATION DRUG FOR IMMUNE THERAPY.“ Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications (Lihe Zhang, Xinjing Tang, Zhen Xi, Jyoti Chattopadhyaya, ed.), J. Wiley, 2023, p41-83.
4. Dejun Ma, Zhen Xi, Gene Nanovector for Genome Therapy. In: Sugimoto, N. (eds) Handbook of Chemical Biology of Nucleic Acids. Springer, 2023, Singapore, pp 1697-1732.
5. Yaqi An*, Ziting Qin, Dandan Li, Ruiqi Zhao, Boshi Bi, Dawei Wang, Dejun Ma, Zhen Xi*. The combined formulation of brassinolide and pyraclostrobin increases biomass and seed yield by improving photosynthetic capacity in Arabidopsis thaliana. Front. Plant. Sci., 14 (2023), DOI: 10.3389/fpls.2023.1138563.
6. Xueying Kang, Haojie Huang, Chenyang Jiang, Longhuai Cheng, Yueqian Sang, Xuekang Cai, Yalun Dong, Lu Sun, Xin Wen, Zhen Xi*, Long Yi*. Cysteine-Activated Small-Molecule H2Se Donors Inspired by Synthetic H2S Donors. J. Am. Chem. Soc., 144 (9) (2022), DOI:10.1021/jacs.1c12006.
7. Dawei Wang, Zhili Pang, Haiyang Yu, Benjamin Thiombiano, Aimee Walmsley, Shuyi Yu, Yingying Zhang, Tao Wei, Lu Liang, Jing Wang, Xin Wen, Harro J. Bouwmeester, Ruifeng Yao, Zhen Xi. Probing strigolactone perception mechanisms with rationally designed small-molecule agonists stimulating germination of root parasitic weeds. Nat Commun. 13(1) (2022), DOI: 10.1038/s41467-022-31710-9.
8. Tao Wei, Xin Wen, Congwei Niu, Sijing An, Dawei Wang, Zhen Xi, Ning Ning Wang. Design of Acetohydroxyacid Synthase Herbicide-Resistant Germplasm through MB-QSAR and CRISPR/Cas9-Mediated Base-Editing Approaches. J. Agric. Food Chem., 70(9) (2022), DOI: 10.1021/acs.jafc.1c07180.
9. Dawei Wang, Baifan Wang, Zhen Xi, “Development of Protoporphyrinogen IX Oxidase Inhibitors for Sustainable Agriculture.” In Crop Protection Products for Sustainable Agriculture (Brittany M. Rauzan and Beth A. Lorsbach, ed.), American Chemical Society, 2021, Washington, Vol. 1390, p11-41.
10.Zhenghua Wang, Cancan Zhao, Qiangzhe Zhang, Chuanlin Wang, Hang Zhang, Dejun Ma, Dawei Wang, Xin Wen, Luyuan Li, Zhen Xi. Design, synthesis and systematic evaluation of all possible cyclic dinucleotides (CDNs) that activate human stimulator of interferon genes (STING) variants. Sci China Chem. 63(4) (2020) , DOI: 10.1007/s11426-019-9662-5.

*以上信息由高级会员个人更新和维护。