罗稳

男， 河南大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2001/09–2005/06，河南大学，化学化工学院，化学，学士
2005/09–2008/06，河南大学，化学化工学院，有机化学，硕士，导师：赵瑾，王超杰
2008/09–2011/06，中山大学，药学院，药物化学，博士，导师：古练权，黄志纾
2011/07–至今，河南大学，天然药物创新与转化重点实验室，工作
2018/09–2019/09，美国南佛罗里达大学，访问学者，合作导师：季海涛

研究领域和兴趣

药物化学，化学生物学

主要业绩

工作以来获得河南省优秀博士后，河南省青年骨干教师，开封市科技创新人才。主持国家自然科学基金2项，主持中国博士后项目，河南省科技厅项目以及河南省教育厅基金各1项。2018-2019在美国南佛罗里达大学莫菲特癌症研究中心做访问学者。工作以来共发表SCI研究论文五十余篇，授权国家发明专利6件。中国化学会、河南省化学会和河南省药学会会员，河南省活性多肽类药物工程中心顾问，省科学基金评审库专家，多个药学期刊杂志审稿人。

代表成果

1. Hui Zhou, Jihang Zhai, Huiyuan Gong, Ru Fang, Yongmei Zhao, Wen Luo*. Novel pyrrolidine-alkylamino-substituted dicyanoisophorone derivatives as near-infrared fluorescence probe for imaging β-amyloid in vitro and in vivo. Anal. Chim. Acta, 2024, 1317, 342894. Doi: 10.1016/j.aca.2024.342894.
2. Hui Zhou, Yang Li, Ru Fang, Jinghua Li, Chen Hong*, Wen Luo*. A dicyanoisophorone-based long-wavelength fluorescent probe for detection of cysteine in vitro and in vivo. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2024, 304, 123403. Doi: 10.1016/j.saa.2023.123403.
3. Yongmei Zhao, Jianwu Lv, Hongli Yu, Kang Huang, Zhihan Du, Wen Luo*. Dictamnine derivatives as a novel family of dual inhibitors for cholinesterase and β-amyloid aggregation. J. Mol. Struct., 2023, 1293, 136222. Doi: 10.1016/j.molstruc.2023.136222.
4. Zhiyang Zhang, Jianwu Lv, Yu Wang, Hongli Yu, Baolin Guo, Jihang Zhai, Chaojie Wang, Yuan Zhao*, Fangfang Fan*, Wen Luo*. Static binding and dynamic transporting-based design of specific ring-chain-ring acetylcholinesterase inhibitor: From galantamine to natural product. Chem. Eur. J., 2023, 29(25):e202203363. Doi: 10.1002/chem.202203363.
5. Jinghua Li , Shuai Chen , Yancong Zhao , Huiyuan Gong, Tong Wang, Xiaoling Ge, Yuxia Wang*, Chenguang Zhu, Liang Chen, Fujun Dai, Songqiang Xie, Chaojie Wang, Wen Luo*. Design, synthesis, and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as a lysosome-targeted anti-metastatic agent. Frontiers in Oncology. 2021, 11, 733589. Doi: 10.3389/fonc.2021.733589.
6. Yantao Liu, Wen Luo,* Zhenjie Wang, Yuxin Zhao, Jingjing Zhao,* Xuejun Xu, Chaojie Wang, Pan Li*. Visible-light photoredox-catalyzed formal [5+1] cycloaddition of N-tosyl vinylaziridines with difluoroalkyl halides. Org. Lett. 2020, 22, 9658−9664. Doi: 10.1021/acs.orglett.0c03718.
7. Juan Cen, Huiyan Guo, Chen Hong, Jianwu Lv, Yacheng Yang, Ting Wang, Dong Fang, Wen Luo*, Chaojie Wang*, Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity. Eur. J. Med. Chem., 2018, 144, 128-136. Doi: 10.1016/j.ejmech.2017.12.005.
8. Qian Li, Zi-xin Zhu, Xin Zhang, Wen Luo*, Li-ping Chang, Shuai Chen, Yu-xia Wang*, Song-qiang Xie, Cong-cong Chang, Chao-jie Wang*, The lead optimization of the polyamine conjugate of flavonoid with a naphthalene motif: Synthesis and biological evaluation. Eur. J. Med. Chem., 2018, 146, 564-576. Doi: 10.1016/j.ejmech.2018.01.074.
9. 罗稳，李景华，黄抗，龚慧媛，赵永梅，一种同分异构体、其制备方法及应用，2020年申请，2021批准，ZL 202011491607.6。
10. 罗稳，吕剑伍，赵永梅，呋喃并喹啉衍生物、其制备方法及应用，2020年申请，2021年批准，ZL 202110116836.8。

*以上信息由高级会员个人更新和维护。