廖建

男， 中国科学院成都生物研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

1990.9-1994.6 上海交通大学 学士
1994.7-1996.8 成都市糖酒公司 营销及管理
1996.9-2002.6 中科院成都有机化学研究所 硕士、博士
2002.7-2003.2 中科院成都有机化学研究所 助理研究员
2003.3-2006.2 美国宾州州立大学 博士后
2006.2-2010.8 中科院成都有机化学研究所 研究员
2010.9-现在 中科院成都生物研究所 研究员

研究领域和兴趣

有机化学-过渡金属不对称催化

主要业绩

聚焦药物、天然产物和重要生物活性分子合成方法，开展手性配体设计和不对称催化研究。建立了一个特色鲜明的前沿研究方向。解决了手性亚砜配体长期存在的催化活性、手性控制和催化类型等关键科学问题。在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等国际专业期刊上发表系列学术论文

代表成果

1.J. Ye, Y. Liao, H. Huang, Y. Liu, D. Fang, M. Wang, L. Hu, J. Liao “Halogenated Salt Assisted Cu-Catalyzed Asymmetric 1,4-Borylstannation of 1,3-Enynes: Enantioselective Synthesis of Allenylstannes” Chem. Sci. 2021, 12, 3032-3038..
2.R. He, X. Huo, L. Zhao, F. Wang, L. Jiang, J. Liao, W. Zhang “Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates” J. Am. Chem. Soc. 2020, 142, 8097-8103.
3.X. Yin, B. Chen, F. Qiu, X. Wang, Y. Liao, M. Wang, X. Lei, Jian Liao “Enantioselective Palladium-Catalyzed Hydrofluorination of Alkenylarenes” ACS Catal. 2020, 10, 1954-1960.
4.Y. Liao, X. Yin, X. Wang, W. Yu, D. Fang, L. Hu, M. Wang, Jian Liao “Enantioselective Synthesis of Multisubstituted Allenes via Co-operative Cu/Pd-Catalyzed 1,4-Arylboration of 1,3-Enynes” Angew. Chem. Int. Ed. 2020, 59, 1176-1180.
5.X. Wang, B. Wang, X. Yin, W. Yu, Y. Liao, J. Ye, M. Wang, L. Hu, J. Liao “Palladium Catalyzed Enantioselective Thiocarbonylation of Styrenes” Angew. Chem. Int. Ed. 2019, 58, 12264-12270.
6.T. Jia, P. Cao, J. Liao “Enantioselective synthesis of gem-diarylalkanes by transition metal-catalyzed asymmetric arylations (TMCAAr)” Chem. Sci. 2018, 9, 546.
7.B. Chen, P. Cao, X. Yin, Y. Liao, L. Jiang, J. Ye, M. Wang, J. Liao “Modular Synthesis of Enantioenriched 1,1,2-Triarylethanes by an Enantioselective Arylboration and Cross-Coupling Sequence” ACS Catal. 2017, 7, 2425.
8.L. Jiang, P. Cao*, M. Wang, B. Chen, B. Wang, J. Liao “Highly Diastereo- and Enantioselective Cu-Catalyzed Borylative Coupling of 1,3-Dienes and Aldimines” Angew. Chem. Int. Ed. 2016, 55, 13854.
9.T. Jia, P. Cao, B. Wang, Y. Lou, X. Yin, M. Wang, J. Liao “A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes” J. Am. Chem. Soc. 2015, 137, 13760 (highlighted by JACS Spots).
10.Y. Lou, P. Cao, T. Jia, Y. Zhang, M. Wang, J. Liao “Cu-Catalyzed Enantioselective 1,6-Boration of para-Quinone Methides and Efficient Transformation of gem-Diarylmethine Boronates to Triarylmethanes” Angew. Chem. Int. Ed. 2015, 54, 12134.
11. D. Wang, P. Cao, B. Wang, T. Jia, Y. Lou, M. Wang, J. Liao “Copper(I)-Catalyzed Asymmetric Pinacolboryl Addition of N-Boc-imines Using a Chiral Sulfoxide–Phosphine Ligand” Org. Lett. 2015, 17, 2420.
12. J. Wang, M. Wang, P. Cao, L. Jiang, G. Chen, J. Liao “Rh-Catalyzed Asymmetric Arylation of β,γ-Unsaturated α-Ketoamides for the Construction of Nonracemic γ,γ-Diarylcarbonyls” Angew. Chem. Int. Ed. 2014, 53, 6673.
13. L. Du, P. Cao, J. Xing, Y. Lou, L. Jiang, L. Li, J. Liao “Hydrogen Bond Promoted Palladium-Catalysis: Allylic Alkylation of Indoles with Unsymmetrical 1,3-Disubstituted Allyl Acetates Using Chiral Bis(sulfoxide) Phosphine Ligands” Angew. Chem. Int. Ed. 2013, 52, 4207.
14. G. Chen, J. Gui, L. Li, J. Liao “Chiral Sulfoxide-Olefin Ligands: Completely Switchable Stereoselectivity in the Rh-Catalyzed Asymmetric Conjugate Additions” Angew. Chem. Int. Ed. 2011, 50, 7681.
15. J. Chen, J. Chen, F. Lang, X. Zhang, L. Cun, J. Zhu, J. Deng, J. Liao “A C2-Symmetric Chiral Bis-Sulfoxide Ligand in Rhodium-Catalyzed Reaction: Asymmetric 1, 4- Addition of Sodium Tetraarylborates to Chromenones” J. Am. Chem. Soc. 2010, 132，4552.

*以上信息由高级会员个人更新和维护。