戴建业

男， 兰州大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2005-2009 沈阳药科大学 药物制剂专业 本科
2009-2014 上海中医药大学 中药学 博士
2014-2018 北京大学 化学生物学 博士后
2018-至今 兰州大学 药学 教授

研究领域和兴趣

基于化学蛋白质组学的药效靶标鉴定

主要业绩

针对中药药效机制深度研究及新药研发过程中存在的问题，戴建业教授采取了多学科交叉的策略，攻克了精准靶标垂钓-定量活性检测-精细机制研究等技术难题，助力中药原始创新研究。上述研究得到了科技部重点研发计划子课题、国家自然科学基金青年项目、西藏自治区科技计划项目重大科研专项、甘肃省自然科学基金重点项目等项目10余项，发表学术论文50余篇，其中在PNAS、Cell metabolism等国际权威期刊发表SCI论文27篇，申请专利20余项（国际专利3项），授权专利10余项（其中PCT专利1项，美国专利1项），另参与编纂专著3部。

代表成果

部分文章：
1. Ruyun Ma*; Kelsang Norbo*; Yanning Zhu; Chunyan Zhu; Feng Zhou; Lobsang Dhondub; Kelsang Gyaltsen; Caisheng Wu; Dai Jianyei#(通讯作者); Chemical proteomics unveils that seventy flavors pearl pill ameliorates ischemic stroke by regulating oxidative phosphorylation, Bioorganic Chemistry, 2024, 145: 107187
2. Zhu Yanning*, Ma Ruyun*, Cheng Wen, Qin Mengyao, Guo Weiheng, Qi Ying, Dai Jianye#(通讯作者). Sijunzi decoction ameliorates gastric precancerous lesions via regulating oxidative phosphorylation based on proteomics and metabolomics. Journal of Ethnopharmacology. 2024. 318(Pt A):116925. doi: 10.1016/j.jep.2023.116925. Epub 2023 Jul 17
3. Ma Yanrong, Zhang Mingkang, Yang Jinru, Zhu Lin, Dai Jianye#(共同通讯作者), Wu Xinan #. Characterization of the renal tubular transport of creatinine by activity-based protein profiling and transport kinetics. European Journal of Pharmaceutical Sciences, 2023, 180:106342. doi: 10.1016/j.ejps.2022.106342. Epub 2022 Nov 24.
4. Liang Kai#, Dai Jianye#(共同通讯作者). Progress of potential drugs targeted in lipid metabolism research. Frontiers in Pharmacology, 2023, 13:1067652. doi: 10.3389/fphar.2022.1067652. eCollection 2022
5. He Rupu, Ma Ruyun, Jin Zheng, Zhu Yanning, Yang Fude, Hu Fangdi, Dai Jianye#(通讯作者). Proteomics and Metabolomics Unveil Codonopsis pilosula (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions via Regulating Energy Metabolism. Frontiers in Pharmacology. 2022, 13:933096. doi: 10.3389/fphar.2022.933096.
6. Cao Huijuan*, Zhou Wei*, Xian Xiaole*, Sun Shujun, Ding Peijie, Tian Chunyu, Tian Fuling, Jiang Chunhua, Fu Tingting, Zhao Shu, Dai Jianye#(通讯作者), A Mixture of Baicalein, Wogonin, and Oroxylin-A Inhibits EMT in the A549 Cell Line via the PI3K/AKT-TWIST1-Glycolysis Pathway, Frontiers in Pharmacology, 2022, 12: 0-821485
7. Wei Xu*, Qi Baoyu*, Ma Ruyun*, Zhang Yili, Liu Ning, Fang Shengjie, Zhu Yanning, Xie Yanming#, Dai Jianye#(共同通讯作者), Zhu Liguo#, Quantitative Proteomics Revealed the Pharmacodynamic Network of Bugu Shengsui Decoction Promoting Osteoblast Proliferation, Front Endocrinol (Lausanne), 2022,12: 0-833474
8. 魏君楠, 戴建业, 中草药活性成分直接作用靶点鉴定研究方法及应用, 中草药, 2021,52(17), 1-113.
9. Ma Yanrong, Xin Mingyan, Wen Yuanjie, Wang Huan, Zhang Guoqiang, Dai Jianye#(共同通讯作者), Wu Xin-An#, The utility of endogenous glycochenodeoxycholate-3-sulfate and 4β-hydroxycholesterol to evaluate the hepatic disposition of atorvastatin in rats, Asian Journal of Pharmaceutical Sciences, 2021, https://doi.org/10.1016/j.ajps.2021.03.002 (期刊论文)
10. Dang Zefang* ; Li Qianhua* ; Sun Shujun* ; Wang Yang* ; Lin Rui; Zhang Yongyu# ; Dai Jianye#(共同通讯作者); Zheng Ningning#, The Medicinal Plant Pair Bupleurum chinense -Scutellaria baicalensis-Metabolomics and Metallomics Analysis in a Model for Alcoholic Liver Injury, Frontiers in Pharmacology, 2019, 10:254, 10.3389/fphar.2019.00254 (期刊论文)
11. Dai Jianye* ; Liang Kai; Zhao Shan; Jia Wentong; Liu Yuan; Wu Hongkun; Lv Jia; Cao Chen; Chen Tao; Zhuang Shentian; Hou Xiaomeng; Zhou Shijie; Zhang Xiannian; Chen Xiao Wei; Huang Yanyi; Xiao Rui Ping; Wang Yan Ling; LuoTuoping; Xiao Junyu; Wang Chu# ,Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis , Proceedings of the National Academy of Sciences of the United States of America, 2018.06.26, 115(26): E5896-E5905 (期刊论文)
部分专利：
1. Jianye Dai; Zheng Jin; Ruyun Ma; Yanning Zhu ; APPLICATIONOFTRANS-1,3-DILINOLEIN IN THE PREPARATION OF MEDICAMENTS FOR TREATING GASTRICCANCER, STOMACHICTONIC, HEALTH PRODUCTS AND FOODS, 2023-9-5, 美国, US 11,744,818B2
2. Dai Jianye, Wang Chu, Qiao Ning, ACTIVATOR FOR SIMULTANEOUSLY ACTIVATING OXIDATIVE PHOSPHORYLATION AND INHIBITING GLYCOLYSIS AND USE THEREOF, PCT/CN2020/000145
3. 戴建业, 王初, 乔宁,与黄芩素抗癌活性相关的两个氧化磷酸化通路关键蛋白,中国, ZL201910459011.9 , 授权
4. 戴建业，张海龙，魏君楠, 一种反式1,3-二亚油精的制备方法,中国, ZL202110026725.8, 授权
5. 戴建业, 金铮, 马茹芸, 朱燕宁, 反式1,3-二亚油精在制备治疗胃癌药物、健胃药物、保健品和食品中的应用,中国, ZL 202110026727.7, 授权

*以上信息由高级会员个人更新和维护。