尹胜

男， 中山大学药学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999/09—2003/07 复旦大学，化学系，学士
2003/09—2008/07 中国科学院上海药物研究所，药物化学，博士
2008/06—2010/10 中国科学院上海药物研究所，助理研究员
2008/06—2010/06 澳大利亚Eskitis研究所，博士后
2010/11—2013/12 中山大学药学院，“百人计划”副教授，博士生导师
2014/01—至今 中山大学药学院，教授，博士生导师

研究领域和兴趣

药用植物资源活性物质基础的发现及新药研究

主要业绩

近5年，申请人建立了以活性为导向的天然产物优势骨架定向挖掘体系，对30余种大戟科药用植物中的二萜成分进行了深入挖掘，取得以下业绩：1）共分离鉴定900余个大戟科二萜，其中新化合物400余个，含12种新颖骨架类型，全合成一类活性新骨架。2）成功将6类大戟科二萜骨架与抗肿瘤、抗肥胖、抗胆汁淤积等活性相关联，发现具有新靶点、新机制的先导化合物6个（已进入临床前研究）。3）发表唯一或最后通讯作者SCI论文50篇，其中20篇发表在该领域top期刊（如JACS、JMC、OL、JNP等），总他引1850次，2个新骨架被Nat. Prod. Rep. 选为热点。曾主持国自然优秀青年基金、"863"青年科学家专项等人才项目。担任多个期刊青年编委，广东省中药专业委员会副主任委员等学术兼职。

代表成果

1. Huang, Jia-Luo#; Yan, Xue-Long#; Li, Wei; Fan, Run-Zhu; Li, Shen; Chen, Jianghe; Zhang, Zhenhua; Sang, Jun; Gan, Lu; Tang, Gui-Hua; Chen, Hongwu; Wang, Junjian*; Yin, Sheng*, Discovery of highly potent daphnane diterpenoids uncovers importin-β1 as a druggable vulnerability in castration-resistant prostate cancer. Journal of the American Chemical Society 2022, 144, 17522–17532. DOI: 10.1021/jacs.2c06449.
2. Zhan, Zha-jun; Li, Shen; Chu, Wang; Yin, Sheng*, Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021). Natural Product Reports 2022, 39, 2132-2174.
3. Li, Wei; Tang, Gui-Hua; Yin, Sheng*, Selaginellins from the genus Selaginella: isolation, structure, biological activity, and synthesis. Natural Product Reports 2021, 38, 822-842.
4. Fan, Run-Zhu#; Chen, Lin#; Su, Tong; Li, Wei; Huang, Jia-Luo; Sang, Jun; Tang, Gui-Hua; Yin, Sheng*, Discovery of 8,9-seco-ent-kaurane diterpenoids as potential leads for the treatment of triple-negative breast cancer. Journal of Medicinal Chemistry 2021, 64, 9926–9942.
5. Lou, Lan-Lan#; Ni, Fu-Qiang#; Chen, Lin; Shaker, Sharpkate; Li, Wei; Wang, Rong; Tang, Gui-Hua; Yin, Sheng*, Germacrane sesquiterpenoids as a new type of anticardiac fibrosis agent targeting transforming growth factor β type I receptor. Journal of Medicinal Chemistry 2019, 62, 7961-7975.
6. Song, Qin-Qin#; Rao, Yong#; Tang, Gui-Hua#; Sun, Zhang-Hua; Zhang, Jun-Sheng; Huang, Zhi-Shu*; Yin, Sheng*, Tigliane diterpenoids as a new type of antiadipogenic agents inhibit GRα-Dexras1 axis in adipocytes. Journal of Medicinal Chemistry 2019, 62, 2060-2075.
7. Zhu, Jian-Yong#; Wang, Rui-Min#; Lou, Lan-Lan; Li, Wei; Tang, Gui-Hua; Bu, Xian-Zhang*; Yin, Sheng*, Jatrophane diterpenoids as modulators of P-glycoprotein-dependent multidrug resistance (MDR): advances of structure-activity relationships and discovery of promising MDR reversal agents. Journal of Medicinal Chemistry 2016, 59, 6353-6369.
8. Huang, Dong#; Zhao, Ying-Yuan#; Wang, Rui-Min; Li, Wei; Yuan, Fang-Yu; Yan, Xue-Long; Yang, Xiao; Tang, Gui-Hua; Yin, Sheng*; Bi, Hui-Chang*, Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity. Acta Pharmacologica Sinica 2022, 43, 2139-2146.
9. Yan, Xue-Long; Sang, Jun; Chen, Shi-Xin; Li, Wei; Tang, Gui-Hua; Gan, Li-She; Yin, Sheng*, Euphorkanlide A, a Highly Modified Ingenane Diterpenoid with a C24 Appendage from Euphorbia kansuensis. Organic Letters 2019, 21, 4128-4131.
10. Li, Wei; Wang, Rui-Min; Pan, Yue-Hua; Zhao, Ying-Yuan; Yuan, Fang-Yu; Huang, Dong; Tang, Gui-Hua; Bi, Hui-Chang; Yin, Sheng*, Crotonpenoids A and B, two highly modified clerodane diterpenoids with a tricyclo[7.2.1.02,7]dodecane core from Croton yanhuii: Isolation, structural elucidation, and biomimetic semisynthesis. Organic Letters 2020, 22, 4435-4439.

*以上信息由高级会员个人更新和维护。