许刚

男， 中国科学院昆明植物研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

1995-1999：西南林业大学，资源学院，获学士学位
2000-2005：中国科学院昆明植物研究所，获博士学位
2005-现在：中国科学院昆明植物研究所，历任助理研究员、副研究员（2007）、研究员（2015）
2007.10-2008.09：香港赛马会中药研究院，访问学者

研究领域和兴趣

天然药物化学 天然药物研发

主要业绩

中国科学院昆明植物研究所研究员，博导；植物化学与西部植物资源持续利用国家重点实验室副主任。研究领域为天然药物化学，重点开展PPAP等复合生源天然产物及我国西南传统药用植物中活性成分的研究，并取得系列原创性研究成果。在天然PPAP的研究中系统性的解决了其分离纯化与活性研究的两大瓶颈，成为了该领域的国际核心团队之一；在传统药用植物的发掘利用研究中，以传统医药知识及化合物结构特征为线索，从西部传统药用植物中发掘出20多个具有抗心脑血管疾病、抗肿瘤和降脂潜力的化合物。主持/完成NSFC-云南联合重点、中科院国际合作项目、中科院“西部之光”交叉团队重点项目、国家基金面上项目、云南省重点基金等30多项；以第一/通讯作者在Chem. Rev., J. Med. Chem., Org. Lett.和Chem. Commun.等国际高水平期刊发表论文80多篇，其中Nature Index期刊论文13篇，研究成果13次被国际权威杂志Nat. Prod. Rep.评为“研究热点-Hot Off Press”；申请发明专利18项，授权13项。先后入选云南省创新团队负责人、云南省中青年学术带头人、中科院西部之光交叉团队负责人和中科院青年创新促进会；获云南省自然科学奖二等奖、中科院朱李月华优秀导师奖和中科院卢嘉锡青年科技奖等。

代表成果

1. Yan-Song Ye#, Rui Liu#, Na-Na Jiang#, Song-Yu Li, Yin Nian*, Gang Xu*, Caged Polycyclic Polyprenylated Acylphloroglucinols as Cav3.2 Low Voltage-Gated Ca2+ Channel Inhibitors from Hypericum curvisepalum, Chem. Commun., 2022, DOI: 10.1039/D2CC05396A.
2. Na-Na Jiang#, Grace Gar-Lee Yue#, Peng Li#, Yan-Song Ye, Adele Joyce Gomes, Frankie Hin-Fai Kwok, Julia Kin-Ming Lee, Si Gao, Clara Bik-San Lau*, Gang Xu*, Discovery of dearomatized isoprenylated acylphloroglucinols with colon tumor suppressive activities in mice via inhibiting NFκB-FAT1-PDCD4 signaling activation, Eur. J. Med. Chem., 2022, 239, 114532.
3. Yan-Song Ye#, Wen-Yan Li#, Shu-Zong Du#, Jian Yang, Yin Nian, Gang Xu, Congenetic hybrids derived from dearomatized isoprenylated acylphloroglucinol with opposite effects on Cav3.1 low voltage-gated Ca2+ channel, J. Med. Chem., 2020, 63, 1709–1716.
4. Yan-Song Ye#, Shu-Zong Du#, Na-Na Jiang#, Hong-Xi Xu, Jian Yang, Wen-Wei Fu, Yin Nian, Gang Xu, Novel meroterpenoids from Hypericum patulum: highly potent late Nav1.5 sodium current inhibitors, Org. Lett., 2020, 22, 56339–6343.
5. Fan Xia#, Wen-Yan Li#, Xing-Wei Yang, Jian Yang, Xian Li*, Yin Nian*, Gang Xu*, Salpratlactones A and B: a pair of cis-trans tautomeric abietanes as Cav3.1 T-Type calcium channel agonists from Salvia prattii, Org. Lett., 2019, 21, 5670–5674.
6. Ya-Li Hu, Kun Hu, Ling-Mei Kong, Xing-Wei Yang*, Gang Xu*, Norascyronones A and B, 2,3,4-nor-polycyclic polyprenylated acylphloroglucinols from Hypericum ascyron, Org. Lett., 2019, 21, 1007–1010.
7. Yong-Ling Wang, Yan-Song Ye, Wen-Wei Fu, Rong Wu, Qian Xiang, Yuan-Zhi Lao, Jin-Ling Yang, Hong-Sheng Tan, Xing-Wei Yang, Bai-Can Yang, Hong-Xi Xu*, Gang Xu*, Garsubelone A, the first dimeric polycyclic polyprenylated acylphloroglucinols with complicated heptacyclic architecture from Garcinia subelliptica, Org. Lett., 2019, 21, 1534–1537.
8. Xing-Wei Yang, Robert B. Grossman, Gang Xu*, Research progress of polycyclic polyprenylated acylphloroglucinols, Chem. Rev., 2018, 118, 3508–3558.
9. Fan Xia#, Da-Wei Zhang#, Chun-Yan Wu#, Hui-Chun Geng#, Wen-Dan Xu, Yu Zhang, Xing-Wei Yang, Hong-Bo Qin,* Gang Xu*, Isolation, structural elucidation, and synthetic studies of salviyunnanone A, an abietane derived diterpenoid with 7/5/6/3 ring system from Salvia yunnanensis, Org. Chem. Front., 2018, 5, 1262–1266.
10. Xing-Wei Yang#, Yan-Ping Li#, Jia Su, Wei-Guang Ma, Gang Xu*, Hyperjapones A–E, terpenoid polymethylated acylphloroglucinols from Hypericum japonicum, Org. Lett., 2016, 18, 1876–1879.
11. Yang Liao#, Xia Liu#, Jing Yang#, Yuan-Zhi Lao#, Xing-Wei Yang, Xiao-Nian Li, Jing-Jing Zhang, Zhi-Jie Ding, Hong-Xi Xu⃰, Gang Xu⃰, Hypersubones A and B, new polycyclic acylphloroglucinols with intriguing adamantane type cores from Hypericum subsessile, Org. Lett., 2015, 17, 1172–1175.
12. Jing-Jing Zhang#, Jing Yang#, Yang Liao, Xing-Wei Yang, Jun-Zeng Ma, Qiu-Li Xiao, Li-Xin Yang, Gang Xu,⃰ Hyperuralones A and B, new acylphloroglucinol derivatives with intricately caged cores from Hypericum uralum, Org. Lett., 2014, 16, 4912–4915.
13. Xing-Wei Yang#, Yuanqing Ding#, Jing-Jing Zhang#, Xia Liu, Li-Xin Yang, Xiao-Nian Li, Daneel Ferreira, Larry A. Walker, Gang Xu,⃰ New acylphloroglucinol derivatives with diverse architectures from Hypericum henryi, Org. Lett., 2014, 16, 2434–2437.
14. Xing-Wei Yang, Xu Deng, Xia Liu, Chun-Yan Wu, Xiao-Nian Li, Bin Wu, Huai-Rong Luo, Yan Li, Hong-Xi Xu, Qin-Shi Zhao, Gang Xu*, Hypercohin A, a new polycyclic polyprenylated acylphloroglucinols possessing an unusual bicyclo[5.3.1]hendecane core from Hypericum cohaerens, Chem. Commun., 2012, 48, 5998–6000.
15. Gang Xu*, Xing-Wei Yang, Chun-Yan Wu, Xiao-Nian Li, Jia Su, Xu Deng, Yan Li, Hong-Bo Qin, Li-Xin Yang, Qin-Shi Zhao, Przewalskone: a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels–Alder reaction from Salvia przewalskii, Chem. Commun., 2012, 48, 4438–4440.

*以上信息由高级会员个人更新和维护。