戴均贵

男， 中国医学科学院药物研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

1987.09-1991.07 华中师范大学生物系 本科生
1991.07-1993.08 湖北省浠水师范学校 教师
1993.09-1996.07 华中师范大学生命科学学院 硕士研究生
1996.09-1999.07 中国协和医科大学药物研究所 博士研究生
1999.07-2001.09 北京大学药学院 博士后
2001.10-2003.10 日本新泻大学化学系 JSPS博士后
2003.11-2007.8 中国医学科学院药物研究所 副研究员
2007.09-至今 中国医学科学院药物研究所 研究员

研究领域和兴趣

药用天然产物生物合成与合成生物学

主要业绩

致力于复杂结构药用天然产物生物合成未知关键酶发现、催化机制、途径解析与创建以及基于合成生物学的新药发现，获得发明专利16项，在Nature Chemistry、Nature Chemical Biology、Angewandte Chemie International Edition、Journal of American Chemical Society等期刊上发表了多篇研究论文。

代表成果

1. Changkang Li,* Yuxin Wang, Xinxin Yin, Xincheng Sun, Songyang Sui, Jimei Liu, Ridao Chen, Kebo Xie, Dawei Chen, Yaotian Han, and Jungui Dai*. Novel α-KG/Fe(II)-dependent dioxygenases catalyzing C1β-hydroxylation and construction of 5/7/6-skeleton of highly oxygenated taxoids. Angewandte Chemie International Edition, 2025, 64, e202517041.
2. Aobo Guo#, Jimei Liu#,* Changkang Li, Shuai Wang, Yaotian Han, Songyang Sui, Yuxin Wang, Xinxin Yin, Beilei Yu, Dawei Chen, Kebo Xie, Ridao Chen*, Jungui Dai*. Four cytochrome P450 enzymes mediate oxidation cascades in the biosynthesis of cephalotane-type diterpenoids. Angewandte Chemie International Edition, 2025, 64, e202512854.
3. Changkang Li#, Xinxin Yin#, Shuai Wang, Songyang Sui, Jimei Liu, Xincheng Sun, Jinming Di, Ridao Chen, Dawei Chen, Yaotian Han, Kebo Xie*, Jungui Dai*. A cytochrome P450 enzyme catalyses oxetane ring formation in paclitaxel biosynthesis. Angewandte Chemie International Edition, 2024, 63, e202407070.
4. Dawei Chen#, *, Zhijun Song#, Junjie Han#, Hongwei Liu*, & Jungui Dai*. Targeted discovery of glycosylated natural products by tailoring enzyme-guided genome mining and MS-based metabolome analysis. Journal of American Chemical Society, 2024, 146, 14, 9614–9622.
5. Ruiqi Yan#, Binghan Xie#, Kebo Xie#, *, Qi Liu, Songyang Sui, Shuqi Wang, Dawei Chen, Jimei Liu, Ridao Chen, Jungui Dai*, Lin Yang*. Unravelling and reconstructing the biosynthetic pathway of bergenin. Nature Communications, 2024, 15, 3539.
6. Changkang Li#, Shuai Wang#, *, Xinxin Yin, Aobo Guo, Kebo Xie, Dawei Chen, Songyang Sui, Yaotian Han, Jimei Liu, Ridao Chen*, and Jungui Dai*. Functional characterization and cyclization mechanism of a diterpene synthase catalyzing the skeleton formation of cephalotane-type diterpenoids. Angewandte Chemie International Edition, 2023, 62, e202306020.
7. Lei Gao#, Cong Su#, Xiaoxia Du#, Ruishan Wang#, Shuming Chen, Yu Zhou, Chengwei Liu, Xiaojing Liu, Runze Tian, Liyun Zhang, Kebo Xie, She Chen, Qianqian Guo, Lanping Guo, Yoshio Hano, Manabu Shimazaki, Atsushi Minami, Hideaki Oikawa, Niu Huang, K. N. Houk, Luqi Huang*, Jungui Dai*, Xiaoguang Lei*. FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis. Nature Chemistry, 2020, 12, 620–628. doi: 10.1038/s41557-020-0467-7
8. Kebo Xie#,*, Xiaolin Zhang#, Songyang Sui, Fei Ye*, and Jungui Dai*. Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides. Nature Communications, 2020, 11, 5162, DOI: 10.1038/s41467-020-18990-9.
9. Ridao Chen#, Bingquan Gao#, Xiao Liu#, Feiying Ruan, Yong Zhang, Jizhong Lou, Keping Feng, Carsten Wunsch, Shu-Ming Li, Jungui Dai*, Fei Sun*. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nature Chemical Biology, 2017, 13, 226-234.
10. Dawei Chen, Ridao Chen, Ruishan Wang, Jianhua Li, Kebo Xie, Chuancai Bian, Lili Sun, Xiaolin Zhang, Jimei Liu, Lin Yang, Fei Ye, Xiaoming Yu, and Jungui Dai*. Probing the catalytic promiscuity of a regio- and stereo-specific C-glycosyltransferase from Mangifera indica. Angewandte Chemie International Edition, 2015, 54, 12678-12682.

*以上信息由高级会员个人更新和维护。