费冬青

男， 兰州大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

09/1999 – 06/2003, 北京化工大学理学院，应用化学专业，学士
09/2003 – 06/2008, 兰州大学化学化工学院，有机化学专业硕博连读，博士
07/2008-04/2011, 兰州大学药学院，讲师
05/2011-11/2020, 兰州大学药学院，副教授
12/2020-目前, 兰州大学药学院，教授

研究领域和兴趣

天然有机化学

主要业绩

本人主要从事我国传统中草药植物中具有重要生物活性和新颖结构萜类化合物的发现研究工作。到目前为止，已经对30多种中草药或植物的化学成分进行了系统的分离分析。生物活性方面，开展了抗AD、抗肿瘤、抗菌、降糖等生物活性研究。到目前为止，已经发现新化合物100多个，其中5个新颖碳骨架萜类化合物teuviscins A, euphorikanin A, crocrassin A, norcrassin A和eupulcherol A被天然产物权威评论杂志Natural Product Reports选为热点化合物。在Organic Letters, Organic Chemistry Frontiers, Organic & Biomolecular Chemistry, RSC Advances，Tetrahedron Letters, Fitoterapia, Planta Medica, Phytochemistry 等SCI杂志上发表论文50多篇。相关研究成果得到了国内外天然药物化学科学家的广泛关注，被JACS，Angewandte Chemie等国际著名期刊所引用。主持和完成多项国家级、省部级以及市级科研项目。现为教育部学位与研究生教育发展中心通讯评议专家，国家自然科学基金通讯评议专家，同时担任多个天然产物SCI杂志的审稿人。2018年，获得甘肃省药学发展奖一等奖。

代表成果

代表性的论文:
1. Yue-qian Li, Bo-lin Hou, Mei-jie Wang, Ru-yue Wang, Xiao-han Chen, Xu Liu, Dong-qing Fei*, Zhan-xin Zhang*, Er-wei Li*. Diterpenoids and C13 Nor-Isoprenoid Identified From the Leaves and Twigs of Croton yanhuii Activating Apoptosis and Pyroptosis. Frontiers in Chemistry 2022, 10, 861278. https://doi.org/10.3389/fchem.2022.861278.
2. Zong-Ping Zhang, Xue Bai, Wen-Bo Cui, Xiao-Han Chen, Xu Liu, De-Juan Zhi, Zhan-Xin Zhang, Dong-Qing Fei*, Dong-Sheng Wang*. Diterpenoid Caesalmin C Delays Aβ-Induced Paralysis Symptoms via the DAF-16 Pathway in Caenorhabditis elegans. International Journal of Molecular Sciences 2022, 23, 6871. https://doi.org/10.3390/ijms23126871.
3. Komi Djimabi, Ru-Yue Wang, Bing Li, Xiao-Han Chen, Xu Liu, Mei-Jie Wang, Xiao-Qing Zhan, Feng-Ming Qi, Dong-Qing Fei*, Zhan-Xin Zhang*. Diterpenoids with α-glucosidase inhibitory activities from the fruits of Vitex trifolia Linn. Fitoterapia 2022, 161, 105248, https://doi.org/10.1016/j.fitote.2022.105248.
4. Pan-Jie Su, Zong-Ping Zhang, Wen-Bo Cui, Xu Liu, Ru-Yue Wang, De-Juan Zhi, Feng-Ming Qi, Xiao-Han Chen, Yue-Qian Li, Komi Djimabi, Yuan-Qiang Guo, Zhan-Xin Zhang*, Dong-Qing Fei*. Polyoxygenated sesquiterpenoids from Salvia castanea and their potential anti-Alzheime's disease bioactivities. Fitoterapia 2021, 151, 104867. https://doi.org/10.1016/j.fitote.2021.104867.
5. Yi-Fan Yu, Ying-Hong Liu, Xiao-Han Chen, De-Juan Zhi, Feng-Ming Qi, Zong-Ping Zhang, Yue-Qian Li, Zhan-Xin Zhang*, Dong-Qing Fei*. Cadinane-type sesquiterpenes from the resinous exudates of Commiphora myrrha and their anti-Alzheimer's disease bioactivities. Fitoterapia 2020, 142, 104536. https://doi.org/10.1016/j.fitote.2020.104536.
6. Chun-Xue Yu, Ru-Yue Wang, Feng-Ming Qi, Pan-Jie Su, Yi-Fan Yu, Bing Li, Ye Zhao, De-Juan Zhi, Zhan-Xin Zhang*, Dong-Qing Fei*. Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer’s disease bioactivity. Organic & Biomolecular Chemistry 2020, 18, 76-80. https://doi.org/10.1039/C9OB02334H.
7. Pei-Qian Wu, Yi-Fan Yu, Ye Zhao, Chun-Xue Yu, De-Juan Zhi, Feng-Ming Qi, Dong-Qing Fei*, Zhan-Xin Zhang*. Four novel sesquiterpenoids with their anti-Alzheimer's disease activity from Nardostachys chinensis. Organic & Biomolecular Chemistry 2018, 16(46), 9038-9045. https://doi.org/10.1039/C8OB02319K.
8. Zhan-Xin Zhang, Pei-Qian Wu, Hui-Hong Li, Feng-Ming Qi, Dong-Qing Fei*, Qiao-Ling Hu, Ying-Hong Liu, Xiao-Ling Huang. Norcrassin A, a novel C16 tetranorditerpenoid, and bicrotonol A, an unusual dimeric labdane-type diterpenoid, from the roots of Croton crassifolius. Organic & Biomolecular Chemistry 2018, 16(10), 1745-1750. https://doi.org/10.1039/C7OB02991H.
9. Zheng-Yu Li, Feng-Ming Qi, De-Juan Zhi, Qiao-Ling Hu, Ying-Hong Liu, Zhan-Xin Zhang*, Dong-Qing Fei*. A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum. Organic Chemistry Frontiers 2017, 4(1), 42-46. https://doi.org/10.1039/C6QO00460A.
10. Dong-Qing Fei*, Le-Le Dong, Feng-Ming Qi, Gai-Xia Fan, Hui-Hong Li, Zheng-Yu Li, Zhan-Xin Zhang*. Euphorikanin A, a diterpenoid lactone with a fused 5/6/7/3 ring system from Euphorbia kansui. Organic Letters 2016, 18(12), 2844-2847. https://doi.org/10.1021/acs.orglett.6b01093.

*以上信息由高级会员个人更新和维护。