王富安

男， 武汉大学化学与分子科学学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999-09 至 2003-07，郑州大学，化学与分子工程学院，化学，学士
2003-09 至 2009-01，中国科学院长春应用化学研究所，电分析化学国家重点实验室，分析化学，博
士
2009-02 至 2014-06，以色列耶路撒冷希伯来大学，博士后
2014-07 至 今，武汉大学，化学与分子科学学院，教授

研究领域和兴趣

生物医学分析

主要业绩

主要从事生物传感分析、核酸纳米技术、生物医学材料等研究。致力于开发新型分析检测方法与探针、开发先进纳米技术与材料、建立智能医学诊疗材料与方法。面向活细胞中核酸原位分析的挑战与需求，以兼具底物特异识别和催化信号放大特性的DNAzyme为分析工具，提出了一种核酸碱基修饰/修复策略，实现了核酸修复酶的高特异性原位检测；同时结合DNAzyme结构和功能重组，创建了核酸有序串联信号扩增新模式，实现了高灵敏度生物分析；进而应用DNAzyme精准反应特性，发展了核酸探针的可控递送新路径和定位激活新方法，实现了活细胞原位分析。近五年作为通讯作者发表SCI论文70篇，包括2篇J. Am. Chem. Soc.，7篇Angew. Chem.，1篇Nat. Commun.，1篇Adv. Mater.，1篇Nucleic Acids Res.，10篇Chem. Sci.，9篇Anal. Chem.、2篇ACS Nano、1篇Matter、2篇CCS Chem.，和8篇 Small等，主持国家级科研项目4项。2013年入选国家青年千人计划，2021年获评湖北省化学化工青年创新奖。

代表成果

Wang, Qing; Tan, Kaiyue; Wang, Hong; Shang, Jinhua; Wan, Yeqing; Liu, Xiaoqing; Weng,
Xiaocheng; Wang, Fuan ; Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging
and Gene Regulation, Journal of the American Chemical Society, 2021, 143(18): 6895-6904.
Wang, Huimin; Chen, Yuqi; Wang, Hong; Liu, Xiaoqing; Zhou, Xiang; Wang, Fuan ; DNAzyme-
Loaded Metal-Organic Frameworks (MOFs) for Self-Sufficient Gene Therapy, Angewandte Chemie
International Edition, 2019, 58(22): 7380-7384.
Wei, Jie; Wang, Huimin; Wu, Qiong; Gong, Xue; Ma, Kang; Liu, Xiaoqing; Wang, Fuan ; A
Smart, Autocatalytic, DNAzyme Biocircuit for in Vivo, Amplified, MicroRNA Imaging, Angewandte
Chemie International Edition, 2020, 59(15): 5965-5971.
Li Ruomeng; Zhu Yuxuan; Gong Xue; Zhang Yanping; Hong Chen; Wan Yeqing; Liu Xiaoqing;
Wang Fuan ; Self-Stacking Autocatalytic Molecular Circuit with Minimal Catalytic DNA Assembly,
Journal of the American Chemical Society, 2023, 145(5): 2999-3007.
Wang, Jing; Yu, Shanshan; Wu, Qiong; Gong, Xue; He, Shizhen; Shang, Jinhua; Liu,
Xiaoqing; Wang, Fuan ; A Self-Catabolic Multifunctional DNAzyme Nanosponge for Programmable Drug
Delivery and Efficient Gene Silencing., Angewandte Chemie International Edition, 2021, 60(19):
10766-10774.
Wang, Huimin; He, Yuqiu; Wei, Jie; Wang, Hong; Ma, Kang; Zhou, Yangjie; Liu, Xiaoqing;
Zhou, Xiang; Wang, Fuan ; Construction of an Autocatalytic Hybridization Assembly Circuit for
Amplified In Vivo MicroRNA Imaging, Angewandte Chemie International Edition, 2022, 61(19):
e202115489.
He, Shizhen; Yu, Shanshan; Li, Ruomeng; Chen, Yingying; Wang, Qing; He, Yuqiu; Liu,
Xiaoqing; Wang, Fuan ; On-Site Non-enzymatic Orthogonal Activation of a Catalytic DNA Circuit for
Self-Reinforced In Vivo MicroRNA Imaging, Angewandte Chemie International Edition, 2022, 61(45):
e202206529.
Gong, Xue; Wang, Haizhou; Li, Ruomeng; Tan, Kaiyue; Jie Wei; Wang, Jing; Hong, Chen;
Shang, Jinhua; Liu, Xiaoqing; Liu, Jing; Wang, Fuan ; A smart multiantenna gene theranostic
system based on the programmed assembly of hypoxia-related siRNAs, Nature Communications, 2021,
12: 3953.
Gong, Xue; Li, Ruomeng; Wang, Jing; Wei, Jie; Ma, Kang; Liu, Xiaoqing; Wang, Fuan ; A
Smart Theranostic Nanocapsule for Spatiotemporally Programmable Photo-Gene therapy, Angewandte
Chemie International Edition, 2020, 59(48): 21648-21655.
Sun, Junlin; Liu, Feng; Yu, Wenqian; Fu, Dandan; Jiang, Qunying; Mo, Fengye; Wang,
Xiuyuan; Shi, Tianhui; Wang, Fuan; Pang, Dai-Wen; Liu, Xiaoqing ; Visualization of Vaccine
Dynamics with Quantum Dots for Immunotherapy, Angewandte Chemie International Edition, 2021,
60(45): 24275-24283.

*以上信息由高级会员个人更新和维护。