国新华

女， 吉林大学化学学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1980.09-1984.07，吉林大学化学系 本科学生
1995.07-1999.08，松辽水资源保护局，工程师
1999.8-2004.10，美国科学大学，化学&生物化学系 研究生
2004.12-2007.07，长春应用化学研究所 长春质谱中心 博士后
2007.12-2013.09，吉林大学化学学院 副教授
2013.09-现在，吉林大学化学学院 教授/博士生导师

研究领域和兴趣

分析化学，质谱分析和光谱分析，核酸和有机生物分子分析

主要业绩

本人主要在三个方面开展了研究工作：1）核酸二级结构特征的质谱光谱分析方法研究、研究了核酸分子间相互作用和组装；2）基质辅助激光解吸离子化（MALDI）质谱的基质和分析方法研究；3）有机生物分子的质谱离子化机理和碎裂规律研究。利用质谱、CD、紫外、荧光光谱、原子力显微镜、凝胶电泳和拉曼光谱等技术研究了G四链体、i-motif、三螺旋、双链、发卡型等多种核酸结构性质和组装。针对MALDI质谱分析的问题发展了新的基质和方法，发现了电荷遥控下的多肽分子的质谱碎裂规律。已经主持完成和正在主持国家自然科学基金面上项目六项，五项吉林省科技项目和多项企业委托的科技项目。在Nucleic Acids Research，J. Phys. Chem. Lett.，Anal. Chem，Sensors & Actuators: B. Chemical，International Journal of Biological Macromolecules，J. Am. Soc. Mass Spectrom.，Biochemistry等杂志以第一作者和通讯作者发表SCI论文40余篇，获得授权中国国家发明专利5项，多次收到邀请在国内外学术会议发表研究成果。

代表成果

1. Ying Bao, Yang Li, Ling Ling, Xiaoxuan Xiang, Xiaoxia Han, Bing Zhao and Xinhua Guo* Label-Free and Highly Sensitive Detection of Native Proteins by AgIANPs via Surface-Enhanced Raman Spectroscopy, Anal. Chem. 92, (2020), https://dx.doi.org/10.1021/acs.analchem.0c03165
2. Ling Ling, Liyan Jiang,⁎ , Qirui Chen, Bo Zhao, Yueying Li, Xinhua Guo* Rapid and accurate profiling of oligosaccharides in beer by using a reactive matrix via MALDI-TOF MS Food Chemistry 340 (2021), https://doi.org/10.1016/j.foodchem.2020.128208
3. Yang Li, Tianyang Gao, Guantong Xu, Xiaoxuan Xiang, Bing Zhao, Xiao Xia Han,* and Xinhua Guo* Direct Approach toward Label-Free DNA Detection by Surface-Enhanced Raman Spectroscopy: Discrimination of a Single-Base
Mutation in 50 Base-Paired Double Helixes Anal chem, 91,(2019), DOI: 10.1021/acs.analchem.9b01887
4. Yang Li, Tianyang Gao, Guantong Xu, Xiaoxuan Xiang, Xiaoxia Han, Bing Zhao, and Xinhua Guo* Base-Pair Contents and Sequences of DNA Double Helices Differentiated by Surface-Enhanced Raman Spectroscopy, J. Phys. Chem. Lett. 10, (2019), DOI: 10.1021/acs.jpclett.9b00936
5. Xiaoxuan Xiang, Yang Li, Ling Ling, Ying Bao, Yike Su, Xinhua Guo* Label-free and dye-free detection of target DNA based on intrinsic fluorescence of the (3+1) interlocked bimolecular G-quadruplexes, Sensors & Actuators: B. Chemical 290 (2019), https://doi.org/10.1016/j.snb.2019.03.111
6. Ling Ling, Chunsheng Xiao,* Yao Ma, Liyan Jiang, Sheng Wang, Liming Guo, Shimei Jiang, and Xinhua Guo* 2 ‑ Phenyl-3 ‑ ( p‑ aminophenyl) Acrylonitrile: A Reactive Matrix for Sensitive and Selective Analysis of Glycans by MALDI-MS Anal. Chem. 91, (2019), DOI: 10.1021/acs.analchem.9b01434
7. Yang Li, Xiaoxia Han,* Shan Zhou, Yuting Yan, Xiaoxuan Xiang, Bing Zhao, and Xinhua Guo* J. Phys. Chem. Lett. 9，（2018）, DOI: 10.1021/acs.jpclett.8b01353
8. Yang Li, Xiaoxia Han,* Yuting Yan, Yanwei Cao, Xiaoxuan Xiang, Sheng Wang, Bing Zhao, and Xinhua Guo* Label-Free Detection of Tetramolecular i ‑ Motifs by Surface-Enhanced Raman Spectroscopy, Anal. Chem. 90，（2018）, DOI: 10.1021/acs.analchem.7b04277
9. Sheng Wang，Chunsheng Xiao*，Liyan Jiang，Ling Ling，Xuesi Chen，Xinhua Guo* A high sensitive and contaminant tolerant matrix for facile detection of membrane proteins by matrix-assisted laser desorption/ionization mass spectrometry，Analytica Chimica Acta 999 (2018) ，https://doi.org/10.1016/j.aca.2017.11.018
10. Yanwei Cao, Shang Gao, Yuting Yan, Michael F. Bruist,* Bing Wang and Xinhua Guo* Assembly of supramolecular DNA complexes containing both G-quadruplexes and i-motifs by enhancing the G-repeat-bearing capacity of i-motifs，
Nucleic Acids Research, Vol. 45, No. 1（2017），

*以上信息由高级会员个人更新和维护。