赵光辉

男， 兰州大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2001年09月-2005年06月：兰州大学，生物技术专业，理学学士
2005年09月-2008年06月：兰州大学，高分子化学与物理专业，理学硕士
2008年09月-2011年06月：兰州大学，高分子化学与物理专业，理学博士
2011年07月-2015年05月：兰州大学，化学化工学院，讲师
2015年06月-2022年12月：兰州大学，化学化工学院，副教授，硕士生导师
2022年12月-至今： 兰州大学，化学化工学院，教授，博士生导师

研究领域和兴趣

生物医用材料

主要业绩

申请人主要的研究工作是生物医用高分子和纳米材料的设计合成，围绕创伤修复和肿瘤的诊断治疗，重点开展软组织的创伤修复材料、止血材料以及药物输送研究。合成了一系列在肿瘤细胞内可顺次诱导激活的抗肿瘤纳米前药胶束，当其进入肿瘤细胞后，可选择性地提高肿瘤细胞内的H2O2水平，进而在H2O2的诱导下，抗肿瘤前药被激活，导致肿瘤细胞凋亡。解决了传统方式无法输送非稳定药物（如羟基自由基、NO气体以及半衰期较短的氮芥等）的问题。进一步研究了此“顺次诱导激活”策略用于抗菌的可行性，为以后深入广泛地研究“顺次诱导激活”提供依据。研究结果为“顺次诱导激活”药物输送体系的构建提供了新思路，为肿瘤及细菌感染治疗发展了新方法。近年来，主持国家自然科学基金面上项目１项，国家自然科学基金青年项目１项，甘肃省重点研发计划1项，甘肃省自然科学基金项目1项，横向项目5项。以第一或通讯作者在Adv. Funct. Mater.; ACS Appl. Mater. Interfaces; Chem. Comm.; Polym. Chem.; Chem.-Asian J.; J. Phys. Chem.等刊物上已发表论文二十余篇，授权发明专利2项，教学论文1篇。

代表成果

1. 论文：
[1] Shi, Yuting; Cao, Yufei; Cheng, Ju; Yu, Wenwen; Liu, Mingsheng; Yin, Juanjuan; Huang, Congshu; Liang, Xiaoqin; Zhou, Haicun; Liu, Hongbin; Yang, Zheng; Fang, Yu; Wei, Hua; Zhao, Guanghui*; Construction of Self-activated Nanoreactors for Cascade Catalytic Anti-biofilm Therapy Based on H2O2 Self-Generation and Switch-on NO Release, Advanced Functional Materials, 2022, 32(20): 2111148. DOI: 10.1002/adfm.202111148
[2] Cui, Haiyan; Liu, Mingsheng; Yu, Wenwen; Cao, Yufei; Zhou, Haicun; Yin, Juanjuan; Liu, Hongbin; Que, Sheng; Wang, Jingjing; Huang, Congshu; Gong, Chenliang; Zhao, Guanghui*; Copper Peroxide-Loaded Gelatin Sponges for Wound Dressings with Antimicrobial and Accelerating Healing Properties, ACS Applied Materials & Interfaces, 2021, 13(23): 26800-26807. DOI: 10.1021/acsami.1c07409
[3] Cao, Yufei; Liu, Mingsheng; Cheng, Ju; Yin, Juanjuan; Huang, Congshu; Cui, Haiyan; Zhang, Xiangdong; Zhao, Guanghui*; Acidity-Triggered Tumor-Targeted Nanosystem for Synergistic Therapy via a Cascade of ROS Generation and NO Release, ACS Applied Materials & Interfaces, 2020, 12(26): 28975-28984. DOI: 10.1021/acsami.0c04791
[4] Luan, Tingting; Cheng, Lulu; Cheng, Ju; Zhang, Xiaoyun; Cao, Yufei; Zhang, Xiangdong; Cui, Haiyan; Zhao, Guanghui*; Tailored Design of an ROS-Responsive Drug Release Platform for Enhanced Tumor Therapy via "Sequential Induced Activation Processes", ACS Applied Materials & Interfaces, 2019, 11(29): 25654-25663. DOI: 10.1021/acsami.9b01433
[5] Shi, Yuting; Li, Hongping; Cheng, Ju; Luan, Tingting; Liu, Di; Cao, Yufei; Zhang, Xiangdong; Wei, Hua; Liu, Yali; Zhao, Guanghui*; Entirely oligosaccharide-based supramolecular amphiphiles constructed via host-guest interactions as efficient drug delivery platforms, Chemical Communications, 2017, 53(91): 12302-12305. DOI: 10.1039/c7cc06553a
[6]Yuting Shi, Wenwen Yu, Xiaoqin Liang, Ju Cheng, Yufei Cao, Mingsheng Liu, Yu Fang, Zheng Yang, Hongbin Liu, Hua Wei, Guanghui Zhao*; Interpenetrating network expansion sponge based on chitosan and plasma for ultrafast hemostasis of arterial bleeding wounds, Carbohydrate Polymers, 2023, 307: 120590. DOI: 10.1016/j.carbpol.2023.120590
[7] Yufei Cao; Juanjuan Yin; Yuting Shi; Ju Cheng; Yu Fang; Congshu Huang; Wenwen Yu; Mingsheng Liu; Zheng Yang; Haicun Zhou; Hongbin Liu; Jianrong Wang; Zhao, Guanghui*; Starch and Chitosan-based Antibacterial Dressing for Infected Wound Treatment via Self-activated NO Release Strategy, International Journal of Biological Macromolecules, 2022, 220: 1177-1187.
[8] Yuting Shi, Yu Fang, Xiaoqin Liang, Congshu Huang, Yu Liang, Zheng Yang, Jianping Yu, Jianrong Wang and Guanghui Zhao, Yeast cell templated porous hollow silica spheresfor rapid hemostasis accompanied by antibacterial action, Biomaterials Science, 2023, 11: 3104-3113. DOI: 10.1039/d2bm01619b
[9] Shi, Yuting; Ding, Xiaoquan; Cao, Yufei; Zhou, Haicun; Yu, Wenwen; Liu, Mingsheng; Yin, Juanjuan; Liu, Hongbin; Wang, Jingjing; Huang, Congshu; Gong, Chenliang; Wei, Hua*; Zhao, Guanghui*; Preparation and application of quick hemostatic gauze based on biomimetic mineralized thrombin, Biomaterials Science, 2021, 9(18): 6098-6107. DOI: 10.1039/d1bm00917f
[10] Juanjuan Yin, Jianrong Wang, Xue Dong, Congshu Huang, Hua Wei, Zhao, Guanghui*; Negatively charged polymer-shielded supramolecular nano-micelles with stimuli-responsive property for anticancer drug delivery, International journal of pharmaceutics, 2022, 627: 122211. DOI: 10.1016/j.ijpharm.2022.122211

2. 专利：
[1] 赵光辉，崔海燕，尹娟娟，房钰；一种环糊精衍生物及其制备方法和应用，专利号：ZL202110602915.X。
[2] 赵光辉，崔海燕，杨峥；一种纳米过氧化铜及其制备方法和应用，专利号：ZL202110528639.7。

*以上信息由高级会员个人更新和维护。