陈战芬

女， 江汉大学光电材料与技术学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2001年9月~ 2004年6月 华中师范大学化学学院无机化学专业
硕士研究生
2004年9月~2007年6月 南京大学化学化工学院配位化学国家重点实验室无机化学专业 博士研究生
2007年7月~2017年3月 湖北师范大学 讲师、副教授
2011年5月~ 2014年5月 华中科技大学 博士后
2019年1月~2020年1月 美国伊利诺伊大学厄巴纳-香槟分校（UIUC）访问学者
2017年4月~至今 江汉大学化学与环境工程学院/光电材料与技术学院 副教授、教授

研究领域和兴趣

化学生物学，生物无机化学

主要业绩

研究领域与兴趣：化学生物学；药物化学；生物无机化学；配位化学
(1) 新型金属抗肿瘤药物的设计、合成及作用机理研究；
(2) 金属酶功能和结构的模拟研究；
(3) 生命重要阴阳离子的识别和传感以及相应的生物效应研究。

代表成果

1.Yixuan Wu, Dandan Zhao, Jinting Shang, Wenxin Huang, Zhanfen Chen,* A novel star-shaped trinuclear platinum(II) complex based on a 1,3,5-triazine core displaying potent antiproliferative activity against TNBC by the mitochondrial injury and DNA damage mechanism. Dalton Trans., 2022, 51, 1093010942.
2.Dandan Zhao, Yixuan Wu, Wenxin Huang, Silin Gong, Zhanfen Chen,* DNA binding, DNA cleavage, cellular uptake, cytotoxicity, and apoptosis-inducing ability of a binuclear Schiff base copper(II) complex. New Journal of Chemistry, 2022, 46, 1521915226.
3.Zhanfen Chen,* Yixuan Wu, Qiang Zhang, Yumin Zhang, Biological properties of a benzothiazole-based mononuclear platinum(II) complex as a potential anticancer agent. Journal of Coordination Chemistry, 2020, 73, 18171832.
4.Zhanfen Chen,* Yixuan Wu, Wangxi Wu, Yumin Zhang, Reactivity towards DNA and protein, cellular uptake, cytotoxic activity of a mononuclear copper(II) complex of the thioflavin-T (ThT)-based derivative. Journal of Coordination Chemistry, 2020, 73, 19872003.
5. Zhanfen Chen,* Yixuan Wu, Zhenzhu Zhu, Yumin Zhang, DNA cleavage, DNA/HSA binding study, and antiproliferative activity of a phenolate-bridged binuclear copper(II) complex. Biometals, 2019, 32, 227240.
6. Zhanfen Chen,* Shuping Zhang, Jian Zhang, Zhenzhu Zhu, Enhanced anti-cancer efficacy to cancer cells by a novel monofunctional mononuclear platinum(II) complex containing a mixed S,N,S-donor ligand. New Journal of Chemistry, 2017, 41, 67606768.
7. Zhanfen Chen,* Shuping Zhang, Zhenzhu Zhu, Yumin Zhang, A novel platinum(II) anticancer complex of danysl bis(2-benzothiazolylmethyl)amine with dimethyl sulfoxide as a leaving group: synthesis, cytotoxicity, interaction with DNA and human serum albumin. New Journal of Chemistry, 2017, 41, 63406348.
8. Zhanfen Chen,* Shuping Zhang, Zhen Shen, Zhenzhu Zhu, Jian Zhang, Fluorescent imaging of a new monofunctional platinum(II) complex containing a thioflavin-T (ThT)-based fluorophore. New Journal of Chemistry, 2015, 39, 1592-1596.
9. Zhanfen Chen,* Jian Zhang, Shuping Zhang, Oxidative DNA cleavage promoted by two phenolate-bridged binuclear copper(II) complexes. New Journal of Chemistry, 2015, 39, 1814-1821.
10. Zhanfen Chen,* Yidan Ma, Luoguang Hua, Jian Zhang, The reactivities of benzimidazole derived mononuclear cobalt(II) and nickel(II) complexes towards DNA and protein. Chinese Journal of Inorganic Chemistry, 2014, 30(7), 15251534.
11. Zhanfen Chen,* Jian Zhang, Pan Zeng, Chuanmin Jin, Evaluation of DNA binding, protein interaction, and cytotoxic activity of a mononuclear copper(II) complex. Z. Anorg. Allg. Chem, 2014. 640, 15061513.
12. Zhanfen Chen, Jian Zhang, Changlin Liu, Study on the Interactions between a Dinuclear Nickel Complex and Bovine Serum Albumin by Spectroscopic Techniques. Biometals, 2013, 26, 827838.

*以上信息由高级会员个人更新和维护。