程义云

男， 华东师范大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2000.09-2004.06，中国科学技术大学高分子科学与工程系，本科学生
2004.09-2008.12，中国科学技术大学生命科学学院，硕博连读研究生
2009.02-2009.10，美国圣路易斯华盛顿大学生物医学工程系，博士后
2010.03至今，华东师范大学生命科学学院，研究员

研究领域和兴趣

生物医用高分子材料，生物大分子

主要业绩

围绕生物大分子递送开展研究：（1）发现了含氟高分子在基因递送中的氟效应，发展了一类含氟高分子基因载体；（2）实现了蛋白质胞内递送载体的理性设计；（3）采用超分子化学的策略克服了高分子载体转染效率对分子量的依赖性。在Nat. Mater., Nat. Nanotechnol., Nat. Commun., Sci. Adv., J. Am. Chem. Soc.等发表第一、通讯作者SCI论文150余篇，他引7000余次，授权发明专利8项，受邀在Chem. Rev.和Chem. Soc. Rev.发表综述3篇，为Wiley、Springer主编英文著作2部。获国家自然科学基金杰出青年基金、优秀青年基金、国家重点研发计划等项目10余项；担任Biomaterials Science, Giant, Chinese Chemical Letters, Letters in Drug Design & Discovery等多个SCI刊物编委，Topics in Current Chemistry客座编辑；入选中国化学会举办的2019年“中国青年化学家元素周期表”活动，为“氟”元素代言；获中国化学会青年化学奖、中国化学会高分子青年学者奖、上海市科技进步一等奖等。

代表成果

1）Shen W, Wang R, Fan Q, Gao X, Wang H, Shen Y, Li Y*, Cheng YY*. Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery. CCS Chem. 2020, 2(3), 146–157.
2）Rong GY, Wang CP, Chen LJ, Yan Y, Cheng YY*. Fluoroalkylation promotes cytosolic peptide delivery. Sci. Adv. 2020; 6: eaaz1774.
3）Xu J, Lv J, Zhuang Q, Yang Z, Cao Z, Xu L, Pei P, Wang C, Wu H, Dong Z, Chao Y, Wang C, Yang K, Peng R*, Cheng YY*, Liu Z*. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy. Nat. Nanotechnol., 2020, https://doi.org/10.1038/s41565-020-00781-4.
4) Liu CY, Wang T, Wang H, Zhang S, Ping Y*, Cheng YY*. A Boronic acid-rich Dendrimer with Robust and Unprecedented Efficiency for Cytosolic Protein Delivery and CRISPR-Cas9 Gene Editing. Sci. Adv., 2019, 5, eaaw8922.
5) Zhang S, Wang CP, Chang H, Zhang Q*, Cheng YY*. Off-On Switching of Enzyme Activity by Near-infrared Light-Induced Photothermal Phase Transition of Nanohybrids, Sci. Adv., 2019, 5, eaaw4252.
6) Zhang ZJ, Shen WW, Ling J, Yan Y, Hu JJ, Cheng YY*. The Fluorination Effect of Fluoroamphiphiles in Cytosolic Protein Delivery, Nat. Commun., 2018, 9, 1377. (Highlighted by Nature Research Chemistry Community; Chemistry of Life)
7) Shen W, Wang Q, Shen Y, Gao X, Li L, Yan Y, Wang H, Cheng YY*. Green Tea Catechin Dramatically Promotes RNAi Mediated by Low Molecular Weight Polymers, ACS Cent. Sci., 2018, 4, 1326-1333. (Highlighted by ACS, ScienceDaily, EurekAlert, World Tea News, Phys.Org, Science Foundation in China, 中国科学报)
8) Wang CP, Zhang Q, Wang X, Chang H, Zhang S, Tang Y, Xu J, Qi R, Cheng YY*. Dynamic Modulation of Enzyme Activity by Near-infrared Light, Angew. Chem. Int. Ed., 2017, 56, 6767-6772 (Highlighted by Advanced Science News).
9）Wang H, Wang YT, Wang Y, Li TF, Liu HM, Zhang Q, Cheng YY*. Self-assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery. Angew. Chem. Int. Ed., 2015, 54, 11647-11651.
10）Wang MM, Liu HM, Li Lei, Cheng YY*. A Fluorinated Dendrimer Achieves Excellent Gene Transfection Efficiency at Extremely Low Nitrogen to Phosphorus Ratios, Nat. Commun., 2014, 5, 3053. (ESI 1% highly cited papers)

*以上信息由高级会员个人更新和维护。