胡祥龙

男， 中国科学技术大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

学习工作经历

2003-2010 安徽师范大学 化学与材料科学学院 学士 硕士

2010-2014 中国科学技术大学 高分子科学与工程系 博士 中科院优博（导师: 刘世勇教授）

2014-2022 华南师范大学 讲师、副研究员、研究员 博士生导师

2017-2019 香港科技大学 “香江学者计划”博士后（导师：唐本忠院士）

2022-至今 中国科学技术大学 高分子科学与工程系 特任研究员 博士生导师 中科院百人计划

研究领域和兴趣

功能高分子与光学材料研究，包括生物医用高分子、聚集诱导发光材料等 创新生物医药与制剂开发，如聚前药两亲分子、功能蛋白、脂质体等 生物医学诊疗方案开发，涉及肿瘤、感染与炎症、抗衰修复等

主要业绩

迄今，以第一/通讯作者在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., Biomaterials, Research等期刊发表论文40余篇，曾分别被Nature 出版社周刊SciBX 专栏评述、入选JACS 亮点论文专栏并发文报道、入选Research期刊2020最佳论文奖、受邀为Chemistry-A European Journal撰写Concept论文等，SCI论文总引用5800余次，H指数39；担任Nat. Chem., Nat. Commun., Adv. Mater., ACS Nano, Adv. Funct. Mater.等期刊审稿人、担任中国生物医学工程学会青年委员、广东省精准医学应用学会分子影像分会常务委员、广东省药物手性专委会委员等；主持多项国家自然科学基金，作为骨干参加一项国家重点研发计划项目；作为主要发明人获授权10余项中国发明专利。曾发展了一种“聚前药Polyprodrug”策略，用于高效可控药物递送与疾病诊疗，引发基础研究兴趣与产业关注。

代表成果

1. W. H. Wang, Y. T. Zhang, Z. S. Wang, X. P. Liu, S. Y. Lu, X. L. Hu* “ A Native Drug-Free Macromolecular Therapeutic to Trigger Mutual Reinforcing of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction for Cancer Treatment” ACS Nano 2023, 17, 11023-11038.
2. J. Xu, J. J. Tan, C. Z. Song, G. Y. Zhang, X. L. Hu*, S. Y. Liu* “ Self‐Immolative Amphiphilic Poly (ferrocenes) for Synergistic Amplification of Oxidative Stress in Tumor Therapy” Angewandte Chemie-International Edition 2023, 62, e202303829.
3. Q. Q. Shi, Z. Y. Deng, M. X. Hou, X. L. Hu*, S. Y. Liu* "Engineering precise sequence-defined polymers for advanced functions" Progress in Polymer Science 2023, 141, 101677.
4. Z. X. Wang, M. X. Zhan*, X. L. Hu* “Pulsed Laser Excited Photoacoustic Effect for Disease Diagnosis and Therapy” Chemistry-A European Journal 2022, 28, e202200042 (Invited Concept).
5. Z. X. Wang, M. X. Zhan, W. J. Li, C. Y. Chu, D. Xing*, S. Y. Lu, X. L. Hu* “Photoacoustic Cavitation-Ignited Reactive Oxygen Species to Amplify Peroxynitrite Burst by Photosensitization-free Polymeric Nanocapsules” Angewandte Chemie-International Edition 2021, 60, 4720-4731. (ESI Highly Cited Papers)
6. C. Y. Wang, Wei Zhao, B. Cao, Z. X. Wang, Q. Zhou, S. Y. Lu, L. Lu, M. Zhan*, X. L. Hu* “Biofilm-Responsive Polymeric Nanoparticles with Self-adaptive Deep Penetration for In Vivo Photothermal Treatment of Implant Infection” Chemistry of Materials 2020, 32, 7725-7738.
7. C. Z. Yao, Y. M. Li, Z. X. Wang, C. Z. Song, X. L. Hu*, S. Y. Liu* “Cytosolic NQO1 Enzyme-Activated Near-Infrared Fluorescence Imaging and Photodynamic Therapy with Polymeric Vesicles” ACS Nano 2020, 14, 1919-1935.
8. X. J. Guo, B. Cao, C. Y. Wang, S. Y. Lu, X. L. Hu* “In vivo Photothermal Inhibition of Methicillin-resistant Staphylococcus Aureus Infection by in-situ Templated Formulation of Pathogen-Targeting Phototheranostics” Nanoscale 2020, 12, 7651-7659. (ESI Highly Cited Papers)
9. X. L. Liu, M. G. Li, T. Han, B. Cao, Z. J. Qiu, Y. Y. Li, Q. Y. Li, Y. B. Hu, Z. Y. Liu, Jacky W. Y. Lam*, X. L. Hu*, B. Z. Tang* “In-situ Generation of Azonia-containing Polyelectrolytes for Luminescent Photopatterning and Superbug Killing” Journal of the American Chemical Society 2019, 14, 11259-11268.
10. D. Wang*, M. S. Lee, W. H. Xu, G. G. Shan, X. Y. Zheng*, Ryan T. K. Kwok, Jacky W. Y. Lam, X. L. Hu*, B. Z. Tang* “Boosting Non-Radiative Decay to Do Useful Work: Development of Multi-Modality Theranostic System from AIEgen” Angewandte Chemie-International Edition 2019, 58, 5628-5632. (ESI Highly Cited Papers)
11. X. L. Hu#, X. Q. Zhao#, B. Z. He, Z. Zhao, Z. Zheng, P. F. Zhang, X. J. Shi, Ryan T. K. Kwok, Jacky W. Y. Lam, A. J. Qin, B. Z. Tang* “A Simple Approach to Bioconjugation at Diverse Levels: Metal-Free Click Reactions of Activated Alkynes with Native Groups of Biotargets without Prefunctionalization” Research 2018, 2018, 3152870. (Best Paper Award 2020)
12. X. L. Hu, G. H. Liu, Y. Li, X. R. Wang, S. Y. Liu* "Cell-Penetrating Hyperbranched Polyprodrug Amphiphiles for Synergistic Reductive Milieu-Triggered Drug Release and Enhanced Magnetic Resonance Signals", Journal of the American Chemical Society 2015, 137, 362-368. (Highlighted by JACS Spotlights, doi: 10.1021/ja512889n; “ESI Highly Cited Papers”)
13. X. L. Hu, J. M. Hu*, J. Tian, Z. S. Ge, G. Y. Zhang, K. F. Luo, S. Y. Liu* “Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking and Drug Delivery” Journal of the American Chemical Society 2013, 135, 17617-17629. (Highlighted by SciBX, doi: 10.1038/scibx.2013.1366; rated as “ESI Hot Papers”, “ESI Highly Cited Papers”)

*以上信息由高级会员个人更新和维护。