卜宪章

男， 中山大学药学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1990-09 至 1994-07, 武汉大学, 环境学, 学士
1994-09 至 1997-07, 武汉大学, 环境电化学, 硕士
1997-09 至 2000-07, 中山大学, 生物有机化学, 博士
2001-01 至 2002-01, 香港科技大学, 生物技术研究所, 副研究员
2002-08 至 2003-08, 香港科技大学, 生物技术研究所, 副研究员
2003-11 至 2004-05, 中山大学, 药学院, 讲师
2004-06 至 2009-05, 中山大学, 药学院, 副教授
2009-06 至 今, 中山大学, 药学院, 教授

研究领域和兴趣

基于创新机制的药物设计与发现

主要业绩

长期坚持药学多学科融合基础上的药物研究工作，致力于基于免疫调控的抗肿瘤、AD等重大疾病的机制与药物设计与发现。主要学术成果包括 1）发展了天然环肽的仿生合成策略，助益活性环肽组合库的构建与药物发现；2）基于天然产物优势片段构建了骨架多样性的化合物库，并从中挖掘了多类生物活性的先导分子；3）基于表型筛选及机制解析策略，解析了多种疾病相关免疫失调机制，并发展了相应抗肿瘤、AD等重大疾病的先导分子。成果发表于Nature Communication, Acta Pharmaceutica Sinica B, J. Med. Chem., ACS Chem. Biol., Chem. Commun., Biochem. Pharmacol., Mol. Cancer Thera等多个专业学术期刊；并获得多项国际国内专利授权部分实现转让开发阶段。工作得到了国家自然科学基金、国家高新技术计划863项目、教育部重点科技项目、广东省自然科学基金以及中山大学百人计划引进人才“行动计划”基金等多项基金资助（主持）。

代表成果

1) Xiaoquan Wang#, Youqiao Wang#, Anqi Cao, Qinhong Luo, Daoyuan Chen, Weiqi Zhao, Jun Xu, Qinkai Li, Xianzhang Bu* & Junmin Quan*, Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation Nature Communications, 2023, 14:6132. https://doi.org/10.1038/s41467-023-41892-5
2) Xin Yue†, Tingyu Liu†, Xuecen Wang†, Weijian Wu, Gesi Wen, Yang Yi, Jiaxin Wu, Ziyang Wange, Weixiang Zhan, Ruirui Wu, Yuan Meng, Zhirui Cao, Liyuan Le, Wenyan Qiu, Xiaoyue Zhang, Zhenyu Li, Yong Chen, Guohui Wan, Xianzhang Bu*, Zhenwei Peng*, Ran-yi Liu*, Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1/BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy, Acta Pharmaceutica Sinica B, 2023, 13(8):3382e3399. https://doi.org/10.1016/j.apsb.2023.05.017.
3) Weijian Wu,† Huiying Xu,† Chenyang Liao, Youqiao Wang, Ruirui Wu, Jiaxin Wu, Wenlv Zheng, Yunzhi Li, Chaoying Jin, Yuxuan Zhao, Junmin Quan, Xin Yue*, Xianzhang Bu*, Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination. Cellular Oncology (2022) 45:1347–1361. https://doi.org/10.1007/s13402-022-00724-2
4) Haixia Sun, Daoyuan Chen, Sirui Zan, Weijian Wu, Huiying Xu, Chunxiang Luo, Hui Su, Yanqiao Feng, Weiyan Shao, Arabella Wan, Binhua Zhou, Guohui Wan * and Xianzhang Bu* Design and Discovery of Natural Cyclopeptide Skeleton Based Programmed Death Ligand-1 Inhibitor as Immune Modulator for Cancer Therapy, Journal of Medicinal Chemistry 2020, 63, 11286−11301 https://doi.org/10.1021/acs.jmedchem.0c01262
5) Gesi Wen1, Daoyuan Chen1, Wenjing Qin, Binhua Zhou, Youqiao Wang, Ziyi Liu, Jun Du, Qiang Zhou, Junmin Quan, Xianzhang Bu*, Stabilizing of Amyloid-β Peptide by the N-terminus Capture is Capable of Preventing and Eliminating Amyloid-β Oligomers. Chem. Commun., 2017, 53, 7673-7676 https://doi.org/10.1039/C7CC03102E
6) Xin Yue1, Yinglin Zuo1, Hongpeng Ke, Jiaming Luo, lanlan Lou, Wenjing Qin, Youqiao Wang, Ziyi Liu, Daoyuan Chen, Haixia Sun, Weichao Zheng, Cuige Zhu, Ruimin Wang, Gesi Wen, Jun Du, Binhua Zhou*, Xianzhang Bu*, Identification of 4-arylidende curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase. Biochem Pharmacol 2017, 137, 29-50. https://doi.org/10.1016/j.bcp.2017.04.032
7) Cuige Zhu, Yinglin Zuo, Baoxia Liang, Hong Yue, Xin Yue, Gesi Wen, Ruimin Wang, Junmin Quan, Jun Du and Xianzhang Bu* Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe，Chem. Commun., 2015, 51, 13400-13403. https://doi.org/10.1039/c5cc04927j
8) Cuige Zhu , Yinglin Zuo , Ruimin Wang , Baoxia Liang , Xin Yue , Gesi Wen , Nana Shang , Lei Huang , Yu Chen , Jun Du , and Xianzhang Bu * Discovery of Potent Cytotoxic Ortho-Aryl Chalcones as New Scaffold Targeting Tubulin and Mitosis with Affinity-Based Fluorescence，J. Med. Chem., 2014, 57 (15), 6364–6382. https://doi.org/10.1021/jm500024v
9) Yun Hu, Yaqi Yang, Yanjun Yu, Gesi Wen, Nana Shang, Wei Zhuang, Dihan Lu, Binhua Zhou, Xin Yue, Baoxia Liang, Jun Du, Feng Li, Xian-Zhang Bu*, Synthesis and Identification of New Flavonoids Targeting Liver X Receptor β Involved Pathway as Potential Facilitators of Aβ Clearance with Reduced Lipid Accumulation. Journal of Medicinal Chemistry, 2013, 56, 6033−6053. https://doi.org/10.1021/jm301913k
10) X Qiu, YH Du, B Lou, YL Zuo, WY Shao, YP Huo, JL Huang, YJ Yu, BH Zhou, J Du，HA Fu* and XZ Bu*, Synthesis and Identification of New 4-Arylidene Curcumin Analogues as Potential Anticancer Agents Targeting Nuclear Factor-B Signaling Pathway. J Med Chem, 2010. 53 (23), 8260–8273. https://doi.org/10.1021/jm1004545

*以上信息由高级会员个人更新和维护。