崔海磊

男， 重庆文理学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2002-2006: B.S.: Chongqing Medical University,
2002-2006: 学士学位：重庆医科大学，药学院；
2006-2011：Ph.D: West China School of Pharmacy, Sichuan University (Supervisior: Prof. Ying-Chun Chen);
2006-2011：博士学位：四川大学，华西药学院 (导师: 陈应春教授);
2011-2014：Postdoc, Okinawa Institute of Science and Technology (OIST), (Supervisior: Prof. Fujie Tanaka );
2011-2014：博士后：冲绳科学技术研究所,（导师: Fujie Tanaka教授）
2014- ：Chongqing University of Arts and Sciences；
2014-至今：重庆文理学院；

研究领域和兴趣

有机催化、不对称催化及杂环合成

主要业绩

本人在杂环合成和不对称催化合成等领域有多年的研究经验，以第一作者或通讯作者身份在国际国内专业刊物上发表SCI论文五十余篇，其他署名SCI论文二十余篇。申请人也参与了德国Thieme出版社有机合成方法学系列丛书《Science of Synthesis》中《Asymmetric Organocatalysis》一书‘Organocatalytic Cascade Reaction’一章的撰写工作；参与撰写意大利化学会丛书TARGETS IN HETEROCYCLIC SYSTEMS: Chemistry and Properties 26卷和17卷各一个章节。另外，作为第一完成人获授权中国专利和美国专利各一项。
独立工作以来，本人实验室主要在基于亚胺和炔类化合物构筑吡咯、吡咯并异喹啉、吡咯并喹啉、苯并呋喃等杂环化合物方面开展工作，同时针对吡咯并异喹啉等目前研究较少的杂环的反应化学进行探究。通过融合金属催化、有机小分子催化、无催化剂反应条件、亚砜转化等方法学研究对吡咯并异喹啉等天然产物重要母核结构进行后期修饰，进而方便快捷地制备类天然产物分子。在此基础上，本人的研究组已经发展了近五十个高效杂环化合物合成反应方法学和修饰反应方法学。

代表成果

1) Xiao-Yan Zhang, Zhi-Wei Yang, Zhong-Zhu Chen, Jun Wang, Dong-Lin Yang, Li-Li Hu, Ze Shen, Jian-Wu Xie, Jin Zhang,* Hai-Lei Cui,* Tandem Copper-Catalyzed Propargylation/Alkyne Azacyclization/Isomerization Reaction under Microwave Irradiation: Synthesis of Fully Substituted Pyrroles. J. Org. Chem. 2016, 81, 1778-1785. DOI: 10.1021/acs.joc.5b02429.
2) Xue Tang, Ming-Cheng Yang, Cui Ye, Li Liu, Hai-Lin Zhou, Xiao-Jie Jiang, Xiao-Lin You, Bo Han,* Hai-Lei Cui,* Catalyst-free [3 + 2] cyclization of imines and Morita–Baylis–Hillman carbonates: a general route to tetrahydropyrrolo[2,1-a]isoquinolines and dihydropyrrolo[2,1-a]isoquinolines. Org. Chem. Front. 2017, 4, 2128-2133. DOI: 10.1039/c7qo00492c.
3) Si-Wei Liu, Ying-Juan Gao, Yin Shi, Lin Zhou, Xue Tang, Hai-Lei Cui,* Synthesis of Benzoindolizines through 1,5-Electrocyclization/Oxidation Cascades. J. Org. Chem. 2018, 83, 13754-13764. DOI: 10.1021/acs.joc.8b02065.
4) Hai-Lei Cui,* Lu Jiang, Hao Tan, Si Liu, Direct Synthesis of Dihydropyrrolo[2,1-a]Isoquinolines through FeCl3 Promoted Oxidative Aromatization. Adv. Synth. Catal. 2019, 361, 4772-4780. DOI: 10.1002/adsc.201900756.
5) Xue-Fei Jiang, Hao Tan, Hai-Lei Cui,* FeCl3 mediated dimerization of dihydropyrrolo [2,1-a]isoquinolines and chlorination of tetrasbstituted pyrroles. Org. Biomol. Chem. 2020, 18, 660-665.DOI: 10.1039/c9ob02607j.
6) Hai-Lei Cui,* Si-Wei Liu, Xue Xiao. Synthesis of Tetrahydroindolizino[8,7‑b]indole Derivatives in the Presence of Fe(OTf)3 or CF3SO3H through Intramolecular Dearomatization of Indole. J. Org. Chem. 2020, 9, 15382-15395. DOI: 10.1021/acs.joc.0c02188.
7) Jia-Qin Li, Hui-Lin Tan, Dan-Dan Ma, Xin-Xin Zhu, Hai-Lei Cui.* Formylation and Bromination of Pyrrolo[2,1‑a]isoquinoline Derivatives with Bromoisobutyrate and Dimethyl Sulfoxide. J. Org. Chem. 2021, 86, 10118-10128. DOI: 10.1021/acs.joc.1c00844.
8) Hai-Lei Cui.* Recent progress in the synthesis of pyrrolo[2,1-a] isoquinolines. Org. Biomol. Chem. 2022, 20, 2779-2801. DOI: 10.1039/d2ob00209d.
9) Hai-Lei Cui,* Xiao-Hui Chen. Synthesis of Pyrrolo[2,1‑a]isoquinolines through Cu-Catalyzed Condensation/Addition/Oxidation/Cyclization Cascade. J. Org. Chem. 2022, 87, 15435-15447. DOI: 10.1021/acs.joc.2c01978.
10) Hai-Lei Cui,* RECENT PROGRESS IN THE MODIFICATION OF HETEROCYCLES BASED ON THE TRANSFORMATION OF DMSO, in TARGETS IN HETEROCYCLIC SYSTEMS- Chemistry and Properties, O. A. Attanasi; B. Gabriele; P. Merino; D. Spinelli, Ed.; Società Chimica Italiana, Roma, Italy, 2022, 26, 222-248. DOI: http://dx.medra.org/10.17374/targets.2024.27.25.

*以上信息由高级会员个人更新和维护。