钮大文

男， 四川大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2006年于东南大学获学士学位
2013年获美国明尼苏达大学博士学位，Advisor: Thomas R. Hoye
2013-2015年在美国麻省理工学院从事博士后研究，Advisor: Stephen L. Buchwald
2015年加入四川大学从事独立科研工作

研究领域和兴趣

糖化学、手性化学、药物合成

主要业绩

主要研究方向为糖类化合物的合成与功能开发，先后负责包括国家自然科学基金在内的国家级、部省级课题十余项，取得了重要的研究成果。其中设计了烯丙基砜糖基供体，实现了蛋白和多肽在水中的直接立体选择性糖基化反应，开发了芳基碳苷的快速合成方法，同时设计了氧苷类化合物的新制备策略。相关成果为研究糖肽、糖蛋白、以及糖类似物的生物学功能提供了重要工具。相关研究结果已发表在Nature Chemistry, Nature Catalysis, Nature Communications, JACS等期刊上。应邀在Reaxys Prize Symposium 做大会报告。获中国化学会青年化学奖，霍英东青年教师奖，Thieme Chemistry Journals Award, Reaxys PhD Prize等奖项。

代表成果

1. Chen Zhang, Hao Zuo, Ga Young Lee, Yike Zou, Qiu-Di Dang, K. N. Houk, Dawen Niu. Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation. Nat. Chem. (2022). DOI: org/10.1038/s41557-022-00918-z
2. Ren-Zhe Li, Da-Qi Liu, Dawen Niu. Asymmetric O-propargylation of secondary aliphatic alcohols. Nat. Catal. 3, 672–680 (2020). DOI: org/10.1038/s41929-020-0462-9
3. Hua Tang, Yu-Biao Tian, Hongyan Cui, Ren-Zhe Li, Xia Zhang, Dawen Niu. Site-switchable mono-O-allylation of polyols. Nat. Commun. 11, 5681 (2020). DOI: org/10.1038/s41467-020-19348-x
4. Li-Qiang Wan, Xia Zhang, Yike Zou, Rong Shi, Jin-Ge Cao, Shi-Yang Xu, Li-Fan Deng, Li Zhou, Yanqiu Gong, Xiaoling Shu, Ga Young Lee, Haiyan Ren, Lunzhi Dai, Shiqian Qi, K. N. Houk, Dawen Niu. Nonenzymatic Stereoselective S-Glycosylation of Polypeptides and Proteins. J. Am. Chem. Soc. 2021, 143, 11919–11926. DOI: org/10.1021/jacs.1c05156
5. Ren-Zhe Li, Hua Tang, Liqiang Wan, Xia Zhang, Zhengyan Fu, Jie Liu, Shengyong Yang, Da Jia, Dawen Niu. Site-Divergent Delivery of Terminal Propargyls to Carbohydrates by Synergistic Catalysis. Chem 2017, 3, 834–845. DOI: org/10.1016/j.chempr.2017.09.007
6. Weidong Shang, Sheng-Nan Su, Rong Shi, Ze-Dong Mou, Guo-Qiang Yu, Xia Zhang, Dawen Niu. Generation of Glycosyl Radicals from Glycosyl Sulfoxides and Its Use in the Synthesis of C-linked Glycoconjugates. Angew. Chem., Int. Ed. 2021, 60, 385–390. DOI: org/10.1002/anie.202009828
7. Yingwei Wang, Li-Fan Deng, Xia Zhang, Ze-Dong Mou, Dawen Niu. A radical approach to make unnatural amino acids through converting C–S bonds in cysteine derivatives to C–C bonds. Angew. Chem., Int. Ed. 2021, 60, 2155–2159. DOI: org/10.1002/anie.202012503
8. Liang Gong, Hongbao Sun, Li-fan Deng, Xia Zhang, Jie Liu, Shengyong Yang, Dawen Niu. Ni-Catalyzed Suzuki-Miyaura Cross-Coupling of α-Oxo-Vinylsulfones to Prepare C-Aryl Glycals and Acyclic Vinyl Ethers. J. Am. Chem. Soc. 2019, 141, 7680–7686. DOI: org/10.1021/jacs.9b02312

*以上信息由高级会员个人更新和维护。