李家柱

男， 烟台大学化学化工学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2000/09–2004/07，烟台大学，生物技术，理学学士
2004/09–2007/07，烟台大学，药物化学，医学硕士
2007/09–2012/02，Inje University（韩国），纳米工学，工学博士
2012/03–2013/02，Yonsei University（韩国），博士后
2013/03–至今，烟台大学，化学化工学院，讲师、副教授、教授，硕士研究生导师

研究领域和兴趣

卟啉与叶绿素化学、BODIPY、近红外光敏剂、光动力疗法

主要业绩

主要从事叶绿素和BODIPY类光动力抗癌光敏剂的设计、合成与开发。主持并完成省部级科研项目2项，横向课题3项，到位经费400余万元；发表SCI收录论文80余篇，授权发明专利3件。基于原创噻吩[3,2-g]吲哚和噻吩[3,2-e]吲哚骨架设计合成了一系列新型具有近红外吸收的苯并噻吩稠并BODIPY类光敏剂并进行了活性评价，部分化合物具有显著的光动力抗癌活性，该成果已实现转化，合同金额30万美元。2021和2022年连续两次指导学生获得全国大学生化学实验创新设计大赛总决赛一等奖。

代表成果

[1] Xiaofan Fu, Yingxiu Man, Changjiang Yu*, Yingzhu Sun, Erhong Hao*, Qinghua Wu, Anzhi Hu, Guangyao Li, Chang-Cheng Wang*, and Jiazhu Li*, Unsymmetrical Benzothieno-Fused BODIPYs as Efficient NIR Heavy-Atom-Free Photosensitizers, J. Org. Chem., 2024, 89(7), 4826–4839.
[2] Xiangmin Wang, Xiaofan Fu, Weibin Bu, Changjiang Yu*, Erhong Hao, Lijuan Jiao, Qinghua Wu*, Rentian Wang, Jinjun Wang*, Jiazhu Li*, Bisbenzothieno[b]-fused BODIPYs as efficient near-infrared heavy-atom-free photosensitizers, Dyes Pigments, 2023, 219, 111591.
[3] Changjiang Yu*, Yingzhu Sun, Suowei Liu, Jiazhu Li*, Jinjun Wang, Yaxiong Wei, Xinsheng Xu*, Mengxue Yang, Lijuan Jiao, and Erhong Hao*, Twisted Benzothieno-Fused BOPHY Dyes as Triplet Photosensitizers with Long-Lived Triplet Excited States, Inorg. Chem., 2024, 63, 21898−21908.
[4] Weibin Bu, Changjiang Yu*, Yingxiu Man, Jiazhu Li*, Qinghua Wu, Shuangying Gui*, Yaxiong Wei*, Lijuan Jiao and Erhong Hao*, Heavy-atom-free triplet benzothiophene-fused BODIPY derivatives for lipid droplet-specific biomaging and photodynamic therapy, Chem. Commun., 2024, 60, 9809–9812.
[5] Chang-Cheng Wang*, Guangyao Li, Wenna Lv, Bin Yang, Jinchun Chen*, and Jiazhu Li*, Self-Photocatalyzed Oxidation of Alkylarenes to Carbonyls with Water, ACS Sustainable Chem. Eng., 2024, 12, 10647−10652.
[6] Changjiang Yu*, Yingzhu Sun, Qinghua Wu, Yongqiang Shi, Lijuan Jiao, Jinjun Wang, Xugang Guo, Jianfeng Li*, Jiazhu Li*, and Erhong Hao*, Synthesis, Properties, and Semiconducting Characteristics of Bisbenzothieno[b]‑Fused BODIPYs, J. Org. Chem., 2023, 88, 14368-14376.
[7] Changjiang Yu*, Yingzhu Sun, Xingbao Fang, Jiazhu Li*, Qinghua Wu, Weibin Bu, Xing Guo, Hua Wang, Lijuan Jiao, and Erhong Hao*, Aromatic-Ring-Fused BOPPY Fluorophores: Synthesis, Spectral, Redox Properties, and Bioimaging Application, Inorg. Chem., 2022, 61, 16718-16729.
[8] Yuanyuan Zhao, Yu Zhao, Changjiang Yu*, Suowei Liu, Yang Liu, Erhong Hao*, Lijuan Jiao, Xinming Xu, Zhen Zhang*, Jiazhu Li*, A novel family of non-symmetric benzothieno[7,6-b]-fused BODIPYs: Synthesis, structures, photophysical properties and lipid droplet-specific imaging in vitro, Dyes Pigments, 2021, 196, 109748.
[9] Jiazhu Li*, Nailiang He, Yang Liu, Ziping Zhang, Xiao Zhang, Xueying Han, Yunyun Gai, Yongming Liu, Jungang Yin* and Jinjun Wang*, Synthesis and photophysical properties of novel pyridine fused chlorophyll a derivatives, Dyes Pigments, 2017, 146, 189-198.
[10] Jiazhu Li, Yang Liu, Xi-Sen Xu, Yan-Long Li, Shan-Guo Zhang, Il Yoon, Young Key Shim, Jin-Jun Wang* and Jun-Gang Yin*, Highly efficient synthesis of novel methyl 132-methylene mesopyropheophorbide a and its stereoselective Michael addition reaction, Org. Biomol. Chem., 2015, 13(7): 1992-1995.

*以上信息由高级会员个人更新和维护。