叶德举

男， 南京大学化学化工学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2000-2004，南京大学化学化工学院，本科
2004-2009，中国科学院上海药物研究所，博士
2009-2014，美国斯坦福大学医学院，博士后
2014-至今，南京大学化学化工学院 教授

研究领域和兴趣

分子成像分析

主要业绩

我的研究主要围绕生物功能分子的精准成像与测量，提出“酶控原位自组装驱动分子成像”的研究思路，通过生物正交化学，把多种模态成像基元和生物分子响应基团有机整合到一个分子探针上，并赋予高灵敏、高特异、快速响应的能力，实现了在一个探针上多种成像信号的精准调控与同步增强，有效解决了分子成像探针在体内的高特性识别、快速响应和高效富集的难题，为活体内生物分子的精准探测建立了高效分子工具和研究方法。创新性成果包括：(1)提出酶促生物正交反应介导小分子成像探针在活体内原位自组装的策略，实现小分子探针在靶组织的高效富集与多模态成像信号的同步增强，成功应用于活体内生物分子的高灵敏测定；(2)设计开发具有多价协同效应的智能响应多模态分子成像探针，提高探针分子在靶组织的识别效率，解决了活体内生物分子高特异成像的难题；(3)发展快速可逆响应的成像探针，显著提升探针与生物分子的响应速率，实现了活体内生物分子的动态成像。已在Nat. Chem., Nat. Biomed. Eng., Nat. Commun. J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Nano, Nano Lett.,等学术期刊发表SCI论文110余篇，他引5100余次，H-index 45。受邀撰写英文专章2章；2015年入选中组部“青年千人计划”；2019年主持国家自然科学基金优秀青年基金(结题评估优秀)。2016年获国际先进材料协会科学家奖章。目前担任南京大学与 ACS 联合创办的《Chemical & Biomedical Imaging)期刊执行主编(郭子建院士担任期刊主编)，兼任中国生物材料学会影像材料与技术分会委员会、中国医药生物技术协会生物医学成像技术分会、中国抗癌协会纳米肿瘤学专业委员会和中国感光学会光学传感与诊疗专业委员会委员。

代表成果

1. Luyan Wu; Yidan Sun; Keisuke Sugimoto; Zhiliang Luo; Yusuke Ishigaki; Kanyi Pu; Takanori Suzuki*; Hong-Yuan Chen; Deju Ye*; Engineering of Electrochromic Materials as Activatable Probes for Molecular Imaging and Photodynamic Therapy. J. Am. Chem. Soc. 2018, 140, 16340.
2. Runqi Yan; Yuxuan Hu; Fei Liu; Shixuan Wei; Daqing Fang; Adam J. Shuhendler; Hong Liu; Hong-Yuan Chen; Deju Ye*; Activatable NIR Fluorescence/MRI Bimodal Probe for in Vivo Imaging by Enzyme-Mediated Fluogenic Reaction and Self-Assembly. J. Am. Chem. Soc. 2019, 141, 1031.
3. Yui Wang; Xiaoming Hu; Jinhui Weng; Jinbo Li; Quli Fan; Yan Zhang; Deju Ye*; Photoacoustic Probe for the Imaging of Tumor Apoptosis by Caspase-Mediated Macrocyclization and Self-Asembly. Angew. Chem. Int. Ed. 2019, 58 4886.
4. Luyan Wu; Ysuke Ishigaki; Yuxuan Hu: Keisuke Sun; Jian He; Takanori Suzuki*; Xiqun Jiang; Hong-Yuan Chen; Deju Ye*; H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo. Nat. Commun. 2020, 11, 446.
5. Ruibing An; Xiaoyang Cheng; Shixuan Wei; Yuxuan Hu; Yidan Sun; Zheng Huang; Hong-Yuan Chen; Deju Ye*; Smart Magnetic and Fluorogenic Photosenitizer Nanoassemblies Enable Redox-Driven Disasembly for Photodynamic Therapy. Angew. Chem. Int. Ed. 2020, 59, 20636.
6. Yuxuan Hu; Junya Zhag; Yinxing Miao; Xidan Wen; Jian Wang; Yidan Sun; Yinfei Chen; Jianguo Lin; Ling Qiu*; Kai Guo*; Hong-Yuan Chen; Deju Ye*; Enzyme-Mediated In Situ Self-Assembly Promotes In Vivo Biorthogonal Reaction for Pretargeted Multimodality Imagine. Angew. Chem. Int. Ed. 2021, 60, 18082.
7. Jianhui Weng; Yuqi Wang Yan Zhang; Deju Ye*; An Activatable Near-Infrared Fluorescence Probe for in Vivo Imaging of Acute Kidney Injury by Targeting Phosphatidylserine and Caspase-3. J. Am. Chem. Soc. 2021, 143, 18294.
8. Luyan Wu; Yusuke Ishigaki: Wenhui Zeno: Takashi Harimoto; Baoli Yin; Yinghan Chen; Shiyi Liao;
Yongchun Liu; Yidan Sun; Xiaobo Zhang: Ying Liu; Yong Liang; Pengfei Sun: Takanori Suzuki*; Guosheng Song*; Quli Fan*; Deju Ye*; Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy. Nat. Commun. 2021, 12, 6145.
9. Luyan Wu; Wenhui Zeng; Yusuke Ishigki; Junya Zhang; He Bai; Takashi Harimoto; Takanori Suzuki; Deju Ye*; A Ratiometric Photoacoustic Probe with a Reversible Response to Hydrogen Sulfide and Hydroxyl Radicals for Dynamc Imaging of Liver Inflammation. Angew. Chem. Int. Ed. 2022, 61, e202209248.
10. Wenhui Zeng; Luyan Wu; Yusuke Ishigaki; Takashi Harimoto; Yuxuan Hu; Yidan Sun; Yuqi Wang; Takanori Suzuki*; Hong-Yuan Chen; Deju Ye*; An Activatable Afterglow/MRI Bimodal Nanoprobe with Fast Response to HaS for In Vivo Imaging of Acute Hepatitis. Angew. Chem. Int. Ed. 2022, 61, e2022111759.
11. Yuqi Wang; He Bai;Yinxing Miao; Jianhui Weng; Zheng Huang; Jiayu Fu; Yan Zhang*; Jianguo Lin*; Deju Ye*; Tailoring a Nar-Infrared Macrocyclization Scaffold Allows the Control of In Situ Self-Assembly for Photoacoustic/PET Bimodal Imaging. Angew. Chem. Int. Ed. 2022, 61, e202200369.
12. Yuqi Wang; Yuxuan Hu; Deju Ye*; Activatable Multimodal Probes for In Vivo Imaging and Theranostics. Angew. Chem. Int. Ed. 2022, 61, e202209512.
13. Lingjun Liu; Junya Zhang; Ruibing An; Qi Xue; Xi Cheng; Yuxuan Hu; Zheng Huang; Luyan Wu; Wenhui Zeng; Yinxing Miao; Jie Li; Yu Zhou; Hong- Yuan Chen; Hong Liu*; Deju Ye*; Smart Nanosensitizers for Activatable Sono-Photodynamic Immunotherapy of Tumors by Redox-Controlled Disassembly. Angew. Chem. Int. Ed. 2023, 63, e202217055.
14. Xidan Wen; Rui Zhang; Yuxuan Hu; Luyan Wu; He Bi; Dongfan Sog; Yanfeng Wang; Ruibing An; Jianhui Weng; Shuren Zhang; Rong Wang; Ling Qiu; Jianguo in; Guandao Gao; Hong Liu*; Zijian Guo*; Deju Ye*; Controlled sequential in situ self-assembly and disassembly of a fluorogenic cisplatin prodrug for cancer theranostics. Nat. Commun. 2023, 14, 80.
15. Wenhui Zeng; Deju Ye*; Seeing cancer via sonoafterglow, Nat. Biomed. Eng. 2023, 7, 197.

*以上信息由高级会员个人更新和维护。