李育林

男， 合肥工业大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2003.09-2007.07，中国科学技术大学化学系，本科生
2007.09-2012.07，中国科学技术大学化学系，博士研究生
2012.09-2015.11，美国普渡大学化学系，博士后
2015.12-2019.11，合肥工业大学化学与化工学院，研究员
2019.12-至今，合肥工业大学化学与化工学院，教授，博士生导师

研究领域和兴趣

DNA纳米自组装化学

主要业绩

长期专注DNA纳米技术领域，在DNA自组装及复合材料制备等方面取得成果如下：（1）发展DNA自组装化学调控方法。利用溶液中共存的响应性分子，发展了通用的DNA动态自组装化学调控策略，既不依赖特殊碱基序列，也不需要特定化学修饰，为生物计算、纳米机器等提供了新的思路；利用不同金属阳离子调控DNA自组装中的非共价相互作用，实现了DNA三维框架结构高浓度下的高产率组装，为避免非共价组装中的“动力学陷阱”提供了解决方案。相关工作发表于Angew. Chem. Int. Ed.和ChemBioChem上。（2）发展“组装+变构”两步法，高产率制备不能直接组装的DNA复杂结构。相关工作发表于Angew. Chem. Int. Ed.。（3）发展框架核酸引导组装策略，程序化构建具有甲烷、乙烷等分子构型的纳米离散组装体，相关工作发表于J. Am. Chem. Soc.和Chem. Commun.上。先后主持国家自然科学基金面上项目1项和青年项目1项。入选安徽省“百人计划”特聘专家。

代表成果

1. Zhichao Mei, Lingjun Wan, Mengzhou Wei, Yulin Li*, Sequence-Independent Logical Regulation of the Assembly and Disassembly of DNA Polyhedra, ChemBioChem, 2023, 24, e202300240 (doi: 10.1002/cbic.202300240).
2. Kaixuan Zhou, Zhichao Mei, Yunxiang Lei, Zhen Guan, Chengde Mao, Yulin Li*, Boosted Productivity in Single-Tile-Based DNA Polyhedra Assembly by Simple Cation Replacement, ChemBioChem, 2022, 23, e202200138 (doi: 10.1002/cbic.202200138).
3. Yulin Li, Zhaoxiang Deng*, “Ag Ion Soldering: An Emerging Tool for Sub-nanomeric Plasmon Coupling and Beyond”, Acc. Chem. Res., 2019, 52, 3442-3454 (doi: 10.1021/acs.accounts.9b00463).
4. Yang Yu, Bang Jin, Yulin Li*, Zhaoxiang Deng*, Stimuli-Responsive DNA Self-Assembly: From Principles to Applications, Chem. Eur. J., 2019, 25, 9785-9798 (doi: 10.1002/chem.201900491).
5. Yongfei Li, Lei Song, Bang Wang, Jianbo He, Yulin Li*, Zhaoxiang Deng*, Chengde Mao*, Universal pH-Responsive and Metal-Ion-Free Self-Assembly of DNA Nanostructures, Angew. Chem. Int. Ed., 2018, 57, 6892-6895 (doi: 10.1002/anie.201804054).
6. Yulin Li, Zhiyu Liu, Guimei Yu, Wen Jiang, Chengde Mao*, Self-Assembly of Molecule-like Nanoparticle Clusters Directed by DNA Nanocages, J. Am. Chem. Soc., 2015, 137, 4320-4323 (doi: 10.1021/jacs.5b01196).
7. Yulin Li, Cheng Tian, Zhiyu Liu, Wen Jiang, Chengde Mao*, Structural Transformation: Assembly of An Otherwise Inaccessible DNA Nanocage, Angew. Chem. Int. Ed., 2015, 54, 5990-5993 (doi: 10.1002/anie.201500755).
8. Yulin Li, Yuanqin Zheng, Ming Gong, Zhaoxiang Deng*. Pt nanoparticles decorated with a discrete number of DNA molecules for programmable assembly of Au-Pt bimetallic superstructures. Chem. Commun., 2012, 48, 3727-3729 (doi: 10.1039/c2cc30370a).
9. Yulin Li, Xiaogang Han, Zhaoxiang Deng*, Logical Regulations of the Aggregation/Dispersion of Gold Nanoparticles via Programmed Chemical Interactions, Langmuir, 2011, 27, 9666-9670 (doi: 10.1021/la201617p).
10. Yulin Li, Xiaogang Han, Zhaoxiang Deng*, Grafting Single-Walled Carbon Nanotubes with Highly Hybridizable DNA sequences: Potential Building Blocks for DNA-Programmed Material Assembly, Angew. Chem. Int. Ed., 2007, 46, 7481-7484 (doi: 10.1002/anie.200701748).

*以上信息由高级会员个人更新和维护。