袁林

男， 湖南大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2002.09-2006.07 南华大学化学化工学院，工学学士；
2006.09-2013.05 湖南大学化学化工学院，理学博士;
2012.06-2015.09 湖南大学化学化工学院，助理教授
2014.02-2015.03 新加坡国立大学化学系，博士后
2015.10-2017.01 湖南大学化学化工学院，副教授
2017.01- 现在 湖南大学化学化工学院，教授

研究领域和兴趣

荧光探针、光学成像、功能染料

主要业绩

袁林博士主要从事有机功能染料和光学探针领域的研究，取得了系列研究成果：
提出同时提高有机荧光探针斯托克斯位移、光稳定性和荧光亮度的协同调控策略，实现细胞内靶标的高信噪比和高分辨率成像；构建化学稳定性高和荧光亮度可控的近红外荧光染料，建立激活型近红外荧光传感新方法，实现活体内靶标的高对比度成像；基于荧光团和识别单元协同调控构建可逆荧光探针，实现细胞和活体内靶标的动态监测和定量分析。目前，开发的近红外荧光染料已被国内外多个课题组用于发展荧光探针与诊疗试剂；开发的部分荧光探针也被生物医学领域专家用于研究细胞功能。

代表成果

1. G. Jiang, H. Liu, H. Liu, G. Ke, T.-B. Ren,* B. Xiong,* X.-B. Zhang, L. Yuan*. Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing. Angew. Chem. Int. Ed. 2023, e202315217. DOI: 10.1002/anie.202315217
2. G. Jiang, X.-F. Lou, S. Zuo, X. Liu, T.-B. Ren, L. Wang, X.-B. Zhang, L. Yuan*. Tuning the Cellular Uptake and Retention of Rhodamine Dyes by Molecular Engineering for High-Contrast Imaging of Cancer Cells. Angew. Chem. Int. Ed. 2023, 62, e202218613. DOI: 10.1002/anie.202218613
3. W. Li, S. Yin, Y. Shen, H. Li, L. Yuan*; X.-B. Zhang*. Molecular Engineering of pH-Responsive NIR Oxazine Assemblies for Evoking Tumor Ferroptosis via Triggering Lysosomal Dysfunction. J. Am. Chem. Soc. 2023, 145, 3736–3747. DOI:10.1021/jacs.2c13222. 
4. L. He, L.-H. He, S. Xu, T.-B. Ren*, X.-X. Zhang, Z.-J. Qin, X.-B. Zhang, L. Yuan*. Engineering of Reversible NIR‐II Redox‐Responsive Fluorescent Probes for Imaging of Inflammation In Vivo. Angew. Chem. Int. Ed. 2022, 61, e202211409. DOI: 10.1002/anie.202211409
5. G. Jiang, T.-B. Ren, E. D’Este, M. Xiong, B. Xiong, K. Johnsson, X.-B. Zhang, L. Wang*, L. Yuan*. A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy. Nat. Commun. 2022, 13, 2264. DOI:10.1038/s41467-022-29547-3.
6. Z. Qin, T.-B. Ren, H. Zhou, X. Zhang, L. He, Z. Li, X.-B. Zhang. L. Yuan*. NIRII-HDs: A Versatile Platform for Developing Activatable NIR-II Fluorogenic Probes for Reliable In Vivo Analyte Sensing. Angew. Chem. Int. Ed. 2022, 61, e202201541. DOI: 10.1002/anie.202201541.
7. D. Cheng, J. Peng, Y. Lv, D. Su, D. Liu, M. Chen, L. Yuan*, X. Zhang. De Novo Design of Chemical Stability Near-infrared Molecular Probes for High-fidelity Hepatotoxicity Evaluation in Vivo. J. Am. Chem. Soc. 2019, 141(15), 6352–6361. DOI: 10.1021/jacs.9b01374.
8. T. Ren, W. Xu, W. Zhang, X. Zhang, Z. Wang, Z. Xiang, L. Yuan*, X. Zhang. A General Method to Increase Stokes Shift by Introducing Alternating Vibronic Structures. J. Am. Chem. Soc. 2018, 140 (24), 7716–7722. DOI: 10.1021/jacs.8b04404
9. T. Ren, W. Xu, Q. Zhang, X. Zhang, S. Wen, H. Yi, L. Yuan*, X. Zhang. Enhancing the Anti-Solvatochromic Two-Photon Fluorescence for Cirrhosis Imaging by Forming a Hydrogen-Bond Network. Angew. Chem. Int. Ed. 2018, 57(25), 7473-7477. DOI:10.1002/anie.201800293
10. D. Cheng, Y. Pan, L. Wang, Z. Zeng, L. Yuan*, X. Zhang, Y.-T. Chang. Selective visualization of the endogenous peroxynitrite in an inflamed mouse model by a mitochondria-targetable two-photon ratiometric fluorescent probe. J. Am. Chem. Soc. 2017, 139, 285-292. DOI: 10.1021/jacs.6b10508

*以上信息由高级会员个人更新和维护。