李延

男， 西北大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1997-9 至 2001-7, 延安大学, 化学教育, 学士
2002-9 至 2005-7, 陕西师范大学, 分析化学, 硕士
2005-9 至 2008-7, 陕西师范大学, 分析化学, 博士
2008-09 至 2011-04, 西北大学, 分析科学研究所, 讲师
2011-04 至 2016-04, 西北大学, 分析科学研究所, 副教授
2014-08 至 2015-08, 美国德州大学奥斯汀分校, 化学系, 访问学者
2016-04 至 2018-04, 西北大学, 分析科学研究所, 教授
2018-04 至今, 西北大学, 化学与材料科学学院, 教授

研究领域和兴趣

生物电分析化学

主要业绩

以构建高灵敏度高选择性核酸表观遗传修饰的电化学发光生物传感分析新方法为主线，以DNA或RNA为分子识别物质，成功合成了多种新型电致化学发光生物探针，发展了多种电化学发光纳米材料信号放大和核酸信号放大策略；建立了测定遗传性疾病、癌症相关的生物标志物（甲基化RNA序列、甲基化DNA序列、羟甲基化DNA序列、酶等）的高灵敏度高选择性电化学发光传感分析新方法；实现了DNA表观遗传修饰的电化学发光高效、特异和动态检测。

代表成果

1. Wanqiao Bai, Ruonan Wu, Zhenjie Xue*, Xiaomin Song, Zeng-ao Xia, Kailin Zhang, Kang Shao, Yan Li*, Tie Wang*, Hollow Porous structures for improving the sensitivity of colorimetric array gas sensors, Advanced Functional Materials, 2024, 2401421.
2. Sijia Li, Jiayue Shi, Xia Yang, Yanxia Qiao, Yang Jiang, Yaqian zhou*, Yan Li*, Chengxiao Zhang, Washing-free electrochemiluminescence biosensor for the simultaneous determination of N6 methyladenosines incorporating a tri-double resolution strategy. ACS Sensors, 2023, 8, 2771–2779.
3. Xia Yang, Shuai Qiao, Wei Zhao, Sijia Li, Yanxia Qiao, Yang Jiang, Yaqian Zhou*, Yan Li*, Homogeneous electrochemiluminescence for highly sensitive determination of demethylase FTO based on target-regulated DNAzyme cleavage and host−guest interaction. Analytical Chemistry, 2023, 95,11420-11428.
4. Wanqiao Bai, Aiping Cui, Meizhou Liu, Xuezhi Qiao, Yan Li*, and Tie Wang*, Signal-Off Electrogenerated chemiluminescence biosensing platform based on the quenching effect between ferrocene and Ru(bpy)32+-functionalized metal−organic frameworks for the detection of methylated RNA, Analytical Chemistry, 2019, 91, 11840−11847.
5. Shangxian Ma, Huiping Sun, Yan Li*, Honglan Qi*, and Jianbin Zheng. Discrimination between 5 hydroxymethylcytosine and 5 methylcytosine in DNA via selective electrogenerated chemiluminescence (ecl) labeling, Analytical Chemistry, 2016, 88, 9934−9940.
6. Y Li, H Deng, JE Dick, AJ Bard*, Analyzing benzene and cyclohexane emulsion droplet collisions on ultramicroelectrodes, Analytical Chemistry, 2015, 87 (21), 11013–11021.
7. Yang Jiang, Xia Yang, Sijia Li, Yanxia Qiao, Yaqian Zhou*, Yan Li*, Chemiluminescence initiated by nebulization of oxidant- and catalyst-free aqueous luminol solutions, Chemical Engineering Journal, 2024, 481, 148753.
8. Yang Jiang, Qian Li, Yun Xu, Wanqiao Bai, Xia Yang, Sijia Li, Yan Li*, Electrochemiluminescent emission potential tunable Cu–Zn–In–S/ZnS nanocrystals for multiplex microRNAs potential-resolved detection, Biosensors and Bioelectronics, 2022, 201, 113980.
9. Aiping Cui, Jianwei Zhang, Wanqiao Bai, Huiping Sun, Lin Bao, Fen Ma, Yan Li∗, Signal-on electrogenerated chemiluminescence biosensor for ultrasensitive detection of microRNA-21 based on isothermal strand-displacement polymerase reaction and bridge DNA-gold nanoparticles, Biosensors and Bioelectronics, 2019, 144, 111664.
10. Sijia Li, Shengtao Zhang, Jiayue Shi, Xia Yang, Huiping Sun, Yan Li*, Sensitive and non-separation 5-hydroxymethylcytosine double-stranded DNA sensing in different mice tissues: Electrogenerated chemiluminescence biosensing method incorporating DNA nanomachine amplification and nanocomposite magnetic separation, Sensors & Actuators: B. Chemical, 2023, 336, 129722.

*以上信息由高级会员个人更新和维护。