张占欣

女， 兰州大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

09/1999 – 06/2003, 河北师范大学，化学专业，学士
09/2003 – 06/2008, 兰州大学化学化工学院，有机化学专业硕博连读，博士
07/2008-目前, 兰州大学药学院，讲师，副教授，教授

研究领域和兴趣

天然产物化学

主要业绩

从事我国传统中草药植物中具有重要生物活性和新颖结构萜类化合物的发现研究工作。对数十种植物的化学成分进行了系统的分离分析。药理活性方面，开展了抗AD、抗PD、抗肿瘤、抗菌、抗糖尿病等生物活性研究。发现的5个新颖碳骨架萜类化合物eupulcherol A, teuviscins A, euphorikanin A, crocrassin A和norcrassin A被天然产物权威评论杂志Natural Product Reports选为热点化合物。在Organic Letters, Organic Chemistry Frontiers, Bioorganic Chemistry, Phytochemistry, Organic & Biomolecular Chemistry, Fitoterapia, Chemistry & Biodiversity, Natural Product Research等SCI杂志上发表研究论文50多篇。先后主持完成国家自然科学基金，甘肃省自然科学基金等项目。

代表成果

1. Xue Bai, Chun-Min Liu, Hui-Jie Li, Zong-Ping Zhang, Wen-Bo Cui, Feng-Li An, Zhan-Xin Zhang*, Dong-Sheng Wang*, Dong-Qing Fei*. Ethyl caffeate attefnuates Aβ-induced toxicity in Caenorhabditis elegans AD models via the insulin/insulin-like growth factor-1 signaling pathway. Bioorganic Chemistry 2023, 139, 106714.
2. Xiao-Han Chen, Xu Liu, Wen-Bo Cui, Feng-Li An, Li Liu, Qian Wu, Jian-Ning Yu, Jian-Ye Dai, Zhan-Xin Zhang*, Dong-Qing Fei*. Highly oxygenated germacrane-type sesquiterpenoids from the whole plant of Salvia cavaleriei H.Lév. and their biological activities. Phytochemistry 2023, 211, 113686.
3. Xu Liu, Xiao-Qing Zhan, Mei-Jie Wang, Wen-Bo Cui, Xiao-Han Chen, Feng-Ming Qi, Jian-Ning Yu, Jian-Ye Dai, Dong-Qing Fei*, Zhan-Xin Zhang*. Bioactive diterpenoids and sesquiterpenoids with different skeletons from Salvia digitaloides Diels. Phytochemistry 2023, 205, 113501.
4. Pan-Jie Su, Zong-Ping Zhang, Wen-Bo Cui, Xu Liu, Ru-Yue Wang, De-Juan Zhi, Feng-Ming Qi, Xiao-Han Chen, Yue-Qian Li, Komi Djimabi, Yuan-Qiang Guo, Zhan-Xin Zhang*, Dong-Qing Fei*. Polyoxygenated sesquiterpenoids from Salvia castanea and their potential anti-Alzheime's disease bioactivities. Fitoterapia 2021, 151, 104867.
5. Wen-Bo Cui, Zong-Ping Zhang, Xue Bai, Shan-Shan Wang, Xiao-Han Chen, Xu Liu, Pan-Jie Su, De-Juan Zhi, Dong-Qing Fei, Zhan-Xin Zhang*, Dong-Sheng Wang*. Cryptotanshinone Alleviates Oxidative Stress and Reduces the Level of Abnormally Aggregated Protein in Caenorhabditis elegans AD Models. International Journal of Molecular Sciences 2022, 23, 10030.
6. Yi-Fan Yu#, Ying-Hong Liu#, Xiao-Han Chen, De-Juan Zhi, Feng-Ming Qi, Zong-Ping Zhang, Yue-Qian Li, Zhan-Xin Zhang*, Dong-Qing Fei*. Cadinane-type sesquiterpenes from the resinous exudates of Commiphora myrrha and their anti-Alzheimer's disease bioactivities. Fitoterapia 2020, 142, 104536.
7. Chun-Xue Yu, Ru-Yue Wang, Feng-Ming Qi, Pan-Jie Su, Yi-Fan Yu, Bing Li, Ye Zhao, De-Juan Zhi, Zhan-Xin Zhang*, Dong-Qing Fei*. Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer’s disease bioactivity. Organic & Biomolecular Chemistry 2020, 18, 76-80.
8. Ye Zhao, Bing Li, Yi-Fan Yu, Pei-Qian Wu, Chun-Xue Yu, Pan-Jie Su, De-Juan Zhi, Feng-Ming Qi, Dong-Qing Fei*, Zhan-Xin Zhang*. Narjatamanins A and B, a pair of novel epimers possessing a 2,3-seco-iridoid skeleton with an unusual 1,10-oxygen bridge from Nardostachys jatamansi and evaluation of their effects on worm paralysis in AD C. elegans. RSC Advances 2019, 9, 24333-24337.
9. Pei-Qian Wu, Yi-Fan Yu, Ye Zhao, Chun-Xue Yu, De-Juan Zhi, Feng-Ming Qi, Dong-Qing Fei*, Zhan-Xin Zhang*. Four novel sesquiterpenoids with their anti-Alzheimer's disease activity from Nardostachys chinensis. Organic & Biomolecular Chemistry 2018, 16, 9038-9045.
10. Zheng-Yu Li, Feng-Ming Qi, De-Juan Zhi, Qiao-Ling Hu, Ying-Hong Liu, Zhan-Xin Zhang*, Dong-Qing Fei*. A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum. Organic Chemistry Frontiers 2017, 4, 42-46.

*以上信息由高级会员个人更新和维护。