韩晓霞

女， 吉林大学超分子结构与材料国家重点实验室， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999.9－2003.6 长春师范大学生物科学专业，获理学学士学位
2004.9－2009.6 吉林大学物理化学专业，硕博连读，获理学博士学位
2009.8－2011.10 日本关西学院大学，JSPS博士后
2011.11－2013.12 德国柏林工业大学，洪堡学者
2013.12－2019.09 吉林大学超分子结构与材料国家重点实验 副教授
2019.09 - 至今 吉林大学超分子结构与材料国家重点实验 教授

研究领域和兴趣

表面增强拉曼光谱在生命科学领域的应用研究

主要业绩

博士学位论文《基于表面增强拉曼散射的蛋白质检测方法研究》获吉林省优秀博士论文和全国百篇优秀博士论文提名奖。获得日本学术振兴会（JSPS）和德国洪堡基金会（Alexander von Humboldt Foundation）的博士后奖学金，先后在日本关西学院大学化学系和德国柏林工业大学Max-Volmer实验室从事博士后研究。2014年回国建立课题组，并独立开展拉曼光谱在生命科学领域的应用研究。迄今为止，以通讯作者或/和第一作者在Nat. Rev. Methods Primers (1篇)、Angew. Chem. Int. Edit. (2篇)、Nano Lett. (3篇)、Redox Biol. (1篇)、ACS Nano (1篇)、Mater. Horiz. (1篇)、Small (2篇)、Biosens. Bioelectron. (2篇)、TrAC-Trend. Anal. Chem. (1篇)、Anal. Chem. (15篇) 等期刊发表SCI论文44篇。参与编写英文专著4部，获省部级奖励4项。

代表成果

[1] Tang, J. Zhu, H. Xie, L. Song, G. Xu, W. Li, L. Cai, X. X. Han,* Mitochondria-Specific Molecular Cross-talk between Ferroptosis and Apoptosis Revealed by In Situ Raman Spectroscopy. Nano Lett. 2024, 24, 2384-2391
[2] J. Zhu, J. Zhu, H. Xie, J. Tang, Y. Miao, L. Cai, P. Hildebrandt,* X. X. Han,* In Situ Raman Spectrosco-py Reveals Cytochrome c Redox-Controlled Modulation of Mitochondrial Membrane Permeabilization That Triggers Apoptosis. Nano Lett. 2024, 24, 370-377
[3] Xu, W. Li, H. Xie, J. Zhu, L. Song, J. Tang, Y. Miao, X. X. Han* In Situ Monitoring of Membrane Protein Electron Transfer via Surface-Enhanced Resonance Raman Spectroscopy. Anal. Chem. 2024, 96, 6-11
[4] Tang, L. Song, H. Xie, J. Zhu, W. Li, G. Xu, L. Cai, X. X. Han,* In Situ and Real-Time Monitoring of Mitochondria–Endoplasmic Reticulum Crosstalk in Apoptosis via Surface-Enhanced Resonance Raman Spectroscopy. Nano Lett. 2023, 23, 8363-8369
[5] H. Xie, L. Song, S. Katz, J. Zhu, Y. Liu, J. Tang, L. Cai, P. Hildebrandt* and X. X. Han*, Electron trans-fer between cytochrome c and microsomal monooxygenase generates reactive oxygen species that accelerates apoptosis, Redox. Biol., 2022, 53, 102340.
[6] X. X. Han*, R. S. Rodriguez, C. L. Haynes*, Y. Ozaki* and B. Zhao*, Surface-enhanced Raman spec-troscopy, Nat. Rev. Methods Primers, 2021, 1, 87.
[7] Liu, Y.; Ma, H.; Han, X. X.*; Zhao, B.* Metal–Semiconductor Heterostructures for Surface-Enhanced Raman Scattering: Synergistic Contribution of Plasmons and Charge Transfer. Mater. Horiz. 2021, 8, 370-382.
[8] Ma, H.; Liu, S.; Liu, Y.; Zhu, J.; Han, X. X.*; Ozaki, Y.; Zhao, B.* In-Situ Fingerprinting Phosphorylated Proteins via Surface-Enhanced Raman Spectroscopy: Single-Site Discrimination of Tau Biomarkers in Alzheimer's Disease. Biosens. Bioelectron. 2021, 171, 112748.
[9] Chen, L.; Tang, J.; Ma, H.; Jin, S.; Xue, X.; Han, X. X.*; Jung, Y. M.* High-efficiency charge transfer on SERS-active semiconducting K2Ti6O13 nanowires enables direct transition of photoinduced electrons to protein redox centers. Biosens. Bioelectron. 2021, 191, 113452.
[10] Zhu, J.; Jiang, M.; Ma, H.; Zhang, H.; Cheng, W.; Li, J.; Cai, L.; Han, X. X.*; Zhao, B. Redox-State-Mediated Regulation of Cytochrome c Release in Apoptosis Revealed by Surface-Enhanced Raman Scattering on Nickel Substrates. Angew. Chem. Int. Ed. 2019, 58, 16499 –16503.

*以上信息由高级会员个人更新和维护。