桂敬汉

男， 中国科学院上海有机化学研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

2003.09-2007.07，安徽师范大学化学与材料科学学院，本科学生
2007.09-2012.07，中国科学院上海有机化学研究所，硕博研究生
2012.07-2013.02，中国科学院上海有机化学研究所，研究助理
2013.02-2016.03，美国Scripps研究所，博士后
2016.03-至今，中国科学院上海有机化学研究所，研究员，课题组长

研究领域和兴趣

天然产物合成

主要业绩

主要从事活性甾体和萜类天然产物的高效合成研究：发展了过氧选择性碎裂的新型化学反应，提出了骨架可控性重组的仿生合成新策略，高效完成了40多个具有重要生物活性的甾体和萜类天然产物的合成（其中26个首次合成），筛选出多个具有新颖化学结构和显著抗氧化、抗肿瘤活性的化合物等。
目前总计发表SCI论文27篇，包括以通讯作者身份在Acc. Chem. Res., J. Am. Chem. Soc.和Angew. Chem. Int. Ed.等顶尖期刊发表的15篇论文。获得国家海外高层次人才青年项目（2017年）和国家基金委优秀青年科学基金（2021年）的资助，并获得科学探索奖, Natural Product Reports Emerging Investigator Lectureship和中国化学会青年化学奖等多个国内和国际的荣誉。

代表成果

1. Wu, J.; Bao, J.; Deng, J.; Tian, H.; Gui, J.* Concise Syntheses of Harziane Diterpenoids by Merging Local Desymmetrization and Radical Retrosynthesis. J. Am. Chem. Soc. 2025, 147, 30599−30605.
2. Huang, G.; Zhang, X.; Gu, Y.-C.; Gui, J.* Divergent Total Syntheses of Rearranged Steroids Swinhoeisterols A–C. J. Am. Chem. Soc. 2025, 147, 20239−20245.
3. Xie, Y.; Bao, J.; Wang, Y.; Shen, Y.; Liang, Z.; Tian, H.; Gui, J.* Enantioselective Total Synthesis of (−)-Rubriflordilactone B by a Bioinspired Skeletal Reorganization Approach. J. Am. Chem. Soc. 2025, 147, 7875−7885.
4. Wang, Y.; Gui, J.* Bioinspired Skeletal Reorganization Approach for the Synthesis of Steroid Natural Products. Acc. Chem. Res. 2024, 57, 568−579.
5. Cen, K.; Bao, J.; Wang, X.; Tian, H.; Wang, Y.; Gui, J.* Bioinspired Divergent Synthesis of Aspersteroids A and B. J. Am. Chem. Soc. 2024, 146, 6481−6486.
6. Song, H.; Zhang, Z.; Cao, C.;* Tang, Z.;* Gui, J.;* Liu, W.* Biocatalytic Steroidal 9α-Hydroxylation and Fragmentation Enable the Concise Chemoenzymatic Synthesis of 9,10-Secosteroids. Angew. Chem. Int. Ed. 2024, 63, e202319624.
7. Wang, X.; Huang, G.; Wang, Y.; Gui, J.* Asymmetric Total Synthesis of the Rearranged Steroid Phomarol Enabled by a Biomimetic SN2′ Cyclization. J. Am. Chem. Soc. 2023, 145, 9354−9363.
8. Yang, P.; Li, Y.-Y.; Tian, H.; Qian, G.-L.; Wang, Y.; Hong, X.;* Gui, J.* Syntheses of Bufospirostenin A and Ophiopogonol A by a Conformation-Controlled Transannular Prins Cyclization. J. Am. Chem. Soc. 2022, 144, 17769−17775.
9. Wang, Y.; Tian, H.; Gui, J.* Gram-Scale Synthesis of Bufospirostenin A by a Biomimetic Skeletal Rearrangement Approach. J. Am. Chem. Soc. 2021, 143, 19576−19586.
10. Ju, W.; Wang, X.; Tian, H.; Gui, J.* Asymmetric Total Synthesis of Clionastatins A and B. J. Am. Chem. Soc. 2021, 143, 13016−13021.
11. Li, X.; Zhang, Z.; Fan, H.; Miao, Y.; Tian, H.; Gu, Y.; Gui, J.* Concise Synthesis of 9,11-Secosteroids Pinnigorgiols B and E. J. Am. Chem. Soc. 2021, 143, 4886−4890.
12. Ning, Y.; Tian, H.; Gui, J.* Biogenesis-Guided Synthesis and Structural Revision of Sarocladione Enabled by Ruthenium-Catalyzed Endoperoxide Fragmentation. Angew. Chem. Int. Ed. 2021, 60, 11222−11226 (VIP).
13. Wang, Y.; Chen, B.; He, X.; Gui, J.* Bioinspired Synthesis of Nortriterpenoid Propindilactone G. J. Am. Chem. Soc. 2020, 142, 5007−5012.
14. Deng, J.; Ning, Y.; Tian, H.; Gui, J.* Divergent Synthesis of Antiviral Diterpenes Wickerols A and B. J. Am. Chem. Soc. 2020, 142, 4690−4695.
15. Wang, Y.; Ju, W.; Tian, H.; Sun, S.; Li, X.; Tian, W.; Gui, J.* Facile Access to Bridged Ring Systems via Point-to-Planar Chirality Transfer: Unified Synthesis of Ten Cyclocitrinols. J. Am. Chem. Soc. 2019, 141, 5021−5033.
16. Wang, Y.; Ju, W.; Tian, H.; Tian, W.; Gui, J.* Scalable Synthesis of Cyclocitrinol. J. Am. Chem. Soc. 2018, 140, 9413−9416.
17. Deng, J.; Wu, J.; Tian, H.; Bao, J.; Shi, Y.; Tian, W.;* Gui, J.* Alkynes From Furans: A General Fragmentation Method Applied to the Synthesis of the Proposed Structure of Aglatomin B. Angew. Chem. Int. Ed. 2018, 57, 3617−3621.

*以上信息由高级会员个人更新和维护。