陈锋

男， 西安交通大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

教育经历：
2007.9-2011.7，西安交通大学，生命科学与技术学院，生命科学基地班，本科
2011.9-2016.9，西安交通大学，生命科学与技术学院，生物医学工程，博士
工作经历：
2016.9-2019.1，西安交通大学，生命科学与技术学院，讲师
2019.2-2022.11，西安交通大学，生命科学与技术学院，副教授
2022.12-至今，西安交通大学，生命科学与技术学院，教授

研究领域和兴趣

生命分析化学，细胞生物物理，核酸表观遗传

主要业绩

围绕细胞分子种类、表观修饰、空间邻近、时间动态、生物物理等多维度与多组学信息，开展化学测量新方法与生物功能研究，以通讯作者或第一作者在Accounts. Chem. Res.、Nat. Protoc.、Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Nucleic Acids Res.、Anal. Chem.、Chinese Chem. Lett.等国内外期刊发表学术论文30余篇；授权国家发明专利10余项。主持国家青年科学基金（B类）与（C类）、重大研究计划（培育项目）、面上项目与陕西省杰出青年科学基金、前沿探索重点项目等，入选陕西省青年科技新星、陕西省化学优秀青年、西安交通大学青年拔尖人才（教授）等支持计划。获陕西省自然科学奖一等奖（3/5）、中国分析测试协会科学技术奖一等奖（3/9）。

代表成果

1. Zhu Li#, Xinyin Li#, Mengying Ye, Wenjing Shu, Yan He, Haotian Li, Feng Chen* and Yongxi Zhao*. Location-Differentiated DNA Hierarchical Cyclic Construction Demarcating Identical Biomolecules Across Cell Membrane Microenvironments. Angewandte Chemie International Edition, 2025, 64, e202505249.
2. Huahang Yu, Mengying Ye, Yingying Guo, Yating Sun, Ke Cao, Feng Chen* and Yongxi Zhao*. ABC-seq Expands Small RNAs Profiling with Successive Nucleic Acid Structure-differentiated Enzymatic Recognition. Angewandte Chemie International Edition, 2025, 64, e202423208.
3. Siyue Fan#, Xinyin Li#, Huan Liu, Mengying Ye, Yan He, Wenhao Fu, Feng Chen* and Yongxi Zhao*. Molecule Differentiation Encoding Microscopy to Dissect Dense Biomolecules in Cellular Nanoenvironments Below Spatial Resolution. Angewandte Chemie International Edition, 2025, 64, e202425136.
4. Feng Chen, Xinyin Li, Min Bai, and Yongxi Zhao*. Visualizing epigenetic modifications and their spatial proximities in single cells using three DNA-encoded amplifying FISH imaging strategies: BEA-FISH, PPDA-FISH and Cell-TALKING. Nature Protocols, 2025, 20, 220-247.
5. Xiaowen Cao, Feng Chen*, Jing Xue, Yue Zhao, Min Bai and Yongxi Zhao*. Hierarchical DNA branch assembly-encoded fluorescent nanoladders for single-cell transcripts imaging. Nucleic Acids Research, 2023, 51, 3, e13.
6. Feng Chen#, Jing Xue#, Min Bai, Chunhai Fan and Yongxi Zhao*. Lighting up Nucleic Acid Modifications in Single Cells with DNA-Encoded Amplification. Accounts of Chemical Research, 2022, 55, 2248-2259.
7. Feng Chen#, Min Bai#, Xiaowen Cao, Jing Xue, Yue Zhao, Na Wu, Lei Zhang, Dexin Zhang, and Yongxi Zhao*. Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications. Nature Communications, 2021, 12, 1965.
8. Feng Chen#, Jing Xue#, Jin Zhang, Min Bai, Xu Yu, Chunhai Fan and Yongxi Zhao*. Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding. Journal of the American Chemical Society, 2020, 142, 6, 2889-2896.
9. Xiaowen Cao, Huahang Yu, Jing Xue, Min Bai, Yue Zhao, Youjun Li, Yongxi Zhao and Feng Chen*. RNA-primed Amplification for Noise-suppressed Visualization of Single-cell Splice Variants. Analytical Chemistry, 2020, 92, 13, 9356-9361.

*以上信息由高级会员个人更新和维护。