王蔚芝

女， 北京理工大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2002.09-2006.06 北京理工大学 应用化学 理学学士
2006.09-2011.06 中国科学院化学研究所 分析化学 理学博士
2011.08-2019.06 国家纳米科学中心 助理研究员、副研究员
2016-11.2017.12 美国斯坦福大学 访问学者
2019.07-2023.08 北京理工大学 副教授
2023.08至今 北京理工大学 教授

研究领域和兴趣

微流控筛选与靶向多肽分析

主要业绩

主要从事基于靶向多肽的高选择性分析。针对复杂生理体系分析中的关键科学问题，基于靶向多肽开展高选择性分析研究并取得创新成果：1) 提出了分子组装介导的协同识别机理并指导靶向多肽设计，显著降低了非特异干扰，提升了靶向多肽亲和力、特异性与稳定性；2) 建立了高内涵微流控芯片多肽筛选新方法，肽库筛选鉴定效率较常规方法显著提高；3) 基于上述机理和方法获得了一系列新型靶向多肽，实现了针对肿瘤相关蛋白等目标物的高选择性识别并应用于临床在体分子分型。相关成果以通讯作者发表于Angew Chem Int Ed、Adv Mater、Chem Sci、ACS Nano、Anal Chem、Lab Chip等SCI期刊。获国家自然科学基金委优秀青年科学基金资助（2023），入选北京市优秀人才培养青年拔尖人才（2016），入选中国科学院青年创新促进会（2019），以第一完成人获中国分析测试协会科学技术（CAIA奖）二等奖（2020）。主持国家自然科学基金委项目、中央军委后保部项目、北京市自然科学基金项目等。任北京市色谱学会常务理事。担任JOAT、Micro-Nano Lett等期刊青年编委。授权发明专利10余项，其中1项已进入临床（体内）应用。

代表成果

[1] Limin Zhang, Mengzhen Li, Minxuan Wang, Lingyun Li, Mingmei Guo, Yubin Ke, Peng Zhou, and Weizhi Wang*. Tailored Cross-beta Assemblies Establish Peptide "Dominos" Structures for Anchoring Undruggable Pharmacophores. Angewandte Chemie International Edition, 61 (2022), DOI:10.1002/anie.202212527
[2] Limin Zhang, Zhenqi Jiang*, Xi Yang, Yixia Qian, Minxuan Wang, Shang Wu, Lingyun Li, Fei Jia, Zihua Wang, Zhiyuan Hu*, Minzhi Zhao*, Xiaoying Tang, Gang Li, Hanbing Shang, Xiaoyuan Chen*, and Weizhi Wang*. A Totipotent "All-In-One" Peptide Sequentially Blocks Immune Checkpoint and Reverses the Immunosuppressive Tumor Microenvironment. Advanced Materials, 35 (2023), DOI: 10.1002/adma.202207330
[3] Weizhi Wang#, Zhuoran Ma#, Shoujun Zhu, Hao Wan, Jingying Yue, Huilong Ma, Rui Ma, Qinglai Yang, Zihua Wang, Qian Li, Yixia Qian, Chunyan Yue, Yuehua Wang, Linyang Fan, Yeteng Zhong, Ying Zhou, Hongpeng Gao, Junshan Ruan, Zhiyuan Hu*, Yongye Liang*, Hongjie Dai*. Molecular cancer imaging in the second near-infrared window using a renal-excreted NIR-II fluorophore-peptide probe. Advanced Materials, 30 (2018), DOI: 10.1002/adma.201800106
[4] Weizhi Wang*, Zhiyuan Hu*. Targeting Peptide-based Probes for Molecular Imaging and Diagnosis. Advanced Materials, 31 (2019), DOI: 10.1002/adma.201804827
[5] Limin Zhang, Yuwei Tian, Mengzhen Li,a Minxuan Wang, Shang Wu, Zhenqi Jiang, Qiqin Wang, and Weizhi Wang*. Peptide nano 'bead-grafting' for SDT-facilitated immune checkpoints blocking. Chemical Science, 13 (2022), DOI: 10.1039/d2sc02728c
[6] Xin Wang, Jinge Zhao, Jian Zhang, Jingtian Cao, Yao Yu, Bokai Ma, Guangle Niu, Shixiang Lu, Limin Zhang*, Weizhi Wang*. π-π Stacking Network-Based Supramolecular Peptide Nanoprobe for Visualization of the ICB-Enhanced Ferroptosis Process. Analytical Chemistry, 96 (2024), DOI: 10.1021/acs.analchem.4c03381
[7] Jinge Zhao, Limin Zhang, Jingtian Cao, Yao Yu, Bokai Ma, Yujiu Jiang, Junfeng Han, Weizhi Wang*. Sequence-Prescribed β‑Sheet for Enhanced Electron Tunneling: Boosting Interface Recognition and Electrochemical Measurement. Analytical Chemistry, 96 (2024), DOI:10.1021/acs.analchem.4c02273
[8] Lingyun Li, Mengzhen Li, Minxuan Wang, Limin Zhang, Yao Yu, Jiatao Zhang*, Bing Ma*, and Weizhi Wang*. A "Cell Space Station" for Spatiotemporal Molecular Manipulation of Immune Checkpoint. ACS Nano, 16 (2022), DOI: 10.1021/acsnano.2c05483
[9] Shang Wu, Limin Zhang, and Weizhi Wang*. Screened alpha-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain. Analytical Chemistry, 94 (2022), DOI: 10.1021/acs.analchem.2c02223
[10] Minxuan Wang, Lingyun Li, Limin Zhang, Jinge Zhao, Zhenqi Jiang, and Weizhi Wang*. Peptide-derived biosensors and their applications in tumor immunology-related detection. Analytical Chemistry, 94 (2022), DOI: 10.1021/acs.analchem.1c04461
[11] Yao Yu, Minxuan Wang, Mengzhen Li, Limin Zhang, Jinge Zhao, Jie Cao*, and Weizhi Wang*. Controlled Recognition and Corona Formation by Cascade Micellar Nanoprobes: for Boosting Glioma Theranostics. Analytical Chemistry, 94 (2022), DOI: 10.1021/acs.analchem.2c02501
[12] Mingmei Guo, Limin Zhang, Yuwei Tian, Minxuan Wang, and Weizhi Wang*. Living-system-driven evolution of self-assembled-peptide probes: for boosting glioma theranostics. Analytical Chemistry, 2021, 93: 8035-8044
[13] Yuehua Wang, Fei Jia, Zihua Wang, Yixia Qian, Linyang Fan, He Gong, Aiqin Luo, Jian Sun, Zhiyuan Hu, Weizhi Wang*. Boosting the theranostic effect of liposomal probes toward prominin-1 through optimized dual-site targeting. Analytical Chemistry, 91 (2019), DOI: 10.1021/acs.analchem.9b00622
[14] Xiangqian Jia, Mingmei Guo, Qiuju Han, Yuwei Tian, Yafei Yuan, Zihua Wang, Yixia Qian, Weizhi Wang*. Synergetic tumor probes for facilitating therapeutic delivery by combined-functionalized peptide ligands. Analytical Chemistry, 92 (2020): DOI: 10.1021/acs.analchem.0c00440

*以上信息由高级会员个人更新和维护。