董梦秋

女， 北京生命科学研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

1992：四川大学生物系生物化学专业，学士
1995：中国科学院上海生物化学研究所，硕士
2001：美国耶鲁大学，分子生物物理与生物化学系，博士
2001–2003: 美国加州大学圣迭戈分校，细胞分子医学系，博士后
2003–2007：美国斯克利普斯研究院，博士后
2007年11月至今：北京生命科学研究所研究员

研究领域和兴趣

生物质谱

主要业绩

董梦秋课题组开发的交联肽段质谱鉴定技术是辅助解析蛋白质结构或蛋白-蛋白相互作用的有效工具，被全球很多实验室采用。相关文章在Nature Methods、Nature Communications、eLife、Journal of Proteome Research、Analytical Chemistry 等期刊上发表。

代表成果

1. Wang JH†, Tang YL†, Gong Z, Jain R, Xiao F, Zhou Y, Tan D, Li Q, Huang N, Liu SQ, Ye K, Tang C*, Dong MQ*, Lei X*. (2022) Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers. Nat Commun. 13(1):1468. doi: 10.1038/s41467-022-28879-4.
2. Jones AX†, Cao Y†, Tang YL†, Wang JH, Ding YH, Tan H, Chen ZL, Fang RQ, Yin J, Chen RC, Zhu X, She Y, Huang N, Shao F, Ye K, Sun RX, He SM, Lei X*, Dong MQ*. (2019) Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers. Nat Commun. 10(1):3911. doi: 10.1038/s41467-019-11917-z.
3. Chen ZL†, Meng JM†, Cao Y†, Yin JL, Fang RQ, Fan SB, Liu C, Zeng WF, Ding YH, Tan D, Wu L, Zhou WJ, Chi H, Sun RX, Dong MQ*, He SM*. (2019) A high-speed search engine pLink with systematic evaluation for proteome-scale identification of cross-linked peptides. Nat Commun. 10(1):3404. doi: 10.1038/s41467-019-11337-z.
4. Ding YH†, Gong Z†, Dong X†, Liu K, Liu Z, Liu C, He SM, Dong MQ*, Tang C*. (2017) Modeling protein excited-state structures from "over-length" chemical cross-links. J Biol Chem. 292(4):1187-1196.
5. Tan D†, Li Q†, Zhang MJ, Liu C, Ma C, Zhang P, Ding YH, Fan SB, Tao L, Yang B, Li X, Ma S, Liu J, Feng B, Liu X, Wang HW, He SM, Gao N, Ye K, Dong MQ*, Lei X*. (2016) Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. eLife. 2016 Mar 8;5. pii: e12509. doi: 10.7554/eLife.12509.
6. Ding YH, Fan SB, Li S, Feng BY, Gao N, Ye K, He SM, Dong MQ*. (2016) Increasing the depth of mass-spectrometry-based structural analysis of protein complexes through the use of multiple cross-linkers. Anal Chem. 88(8):4461-9.
7. Lu S†, Fan SB†, Yang B†, Li YX, Meng JM, Wu L, Li P, Zhang K, Zhang MJ, Fu Y, Luo J, Sun RX, He SM*, and Dong MQ*. (2015) Mapping Native Disulfide Bonds at a Proteome Scale. Nature Methods doi: 10.1038/nmeth.3283.
8. Yang B†, Wu YJ†, Zhu M†, Fan SB†, Lin J, Zhang K, Li S, Chi H, Li YX, Chen HF, Luo SK, Ding YH, Wang LH, Hao Z, Xiu LY, Chen S, Ye K, He SM*, and Dong MQ* (2012) Identification of cross-linked peptides from complex samples. Nature Methods 9(9): 904-906

*以上信息由高级会员个人更新和维护。