顾琼

女， 中山大学药学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1996-2000 安徽中医药大学 本科
2001-2007 中国科学院昆明植物研究所 博士
2007-2009 中山大学药学院 博士后
2010-2014 中山大学药学院 讲师
2014-2015 北卡罗莱纳大学教堂山分校药学院 访问学者
2015-2024 中山大学药学院 副教授
2024-至今 中山大学药学院 教授

研究领域和兴趣

天然产物化学生物学；中药创新药物

主要业绩

研究方向为基于天然产物的创新药物研究。从中药中寻找具有抑制铁死亡、抗骨质疏松和抗肿瘤活性天然产物，对活性分子进行靶标鉴定和成药性优化，发现药物先导物。以第一或通讯作者，在本领域Nat Comm, ACS Cent Sci, Mol Ther, J Med Chem, Org Lett, J Nat Prod和Phytomedicine等经典期刊发表文章80余篇，申请专利70项，授权专利43项，转让16项。主持1项科技部863计划和4项国家自然科学基金和其他多项省市基金。

代表成果

代表性论文：
1. Yuying Fang, Xiucai Chen, Qiongyun Tan, Huihao Zhou, Jun Xu*, Qiong Gu*. Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: a new mechanism of action. ACS Cent Sci 2021, 7, 980-989.
2. Dane Huang#, Chao Zhao#, Ruyue Li, Bingyi Chen, Yuting Zhang, Zhejun Sun, Junkang Wei, Huihao Zhou, Qiong Gu, Jun Xu. Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis. Nat Commun, 2022, 13: 5338.
3. Mengjiao Hao, Zhuoji Guan, Zhikang Zhang, Haopeng Ai, Xing Peng, Huihao Zhou, Jun Xu*, Qiong Gu*. Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-b receptor 1 recycling by stabilizing vimentin. Mol Ther, 2023, 31 (10): 3015-3033.
4. Hao Chen†, Pei Hua†, Dane Huang, Yuting Zhang, Huihao Zhou, Jun Xu, Qiong Gu*. Discovery of spiro[pyrrolidine-3,3'-oxindole] LXRβ agonists for the treatment of osteoporosis. J Med Chem, 2023, 66(1): 752-765.
5. Xing Peng,† Zikang Zhang,† Yuting Zhang,† Huihao Zhou, Wenqi Li, Minxian Dai, Jinsai, Shang, Jun Xu,* Qiong Gu*. Discovery of novel neo-clerodane derivatives as potent dual-functional anti-osteoporosis agents through targeting PPARγ. J Med Chem, 2024, 67 (17): 15738-15755.
6. Dane Huang†, Chao Zhao†, Ruyue Li, Nan Yao, Jun Xu, Qiong Gu*. Discovery of novel anti-osteoporosis lead with bone resorption inhibition and anabolic promotion through chemotype-assembly approach. J Med Chem, 2024, 67 (17): 15311-15327.
7. Mengyang Xu, Chao Zhao, Biying Zhu, Liangyue Wang, Huihao Zhou, Daoguang Yan,* Qiong Gu.* Jun Xu.* Discovering high potent Hsp90 inhibitors as antinasopharyngeal carcinoma agents through fragment assembling approach. J Med Chem, 2021, 64, 2010-2023.
8. Chao Zhao#, Dane Huang#, Ruyue Li, Yida Xu, Shimin Su, Qiong Gu,* Jun Xu.* Identifying novel anti-osteoporosis leads with a chemotype-assembly approach. J Med Chem, 2019, 62, 5885-5900.
9. Shao-Nan Liu, Dane Huang, Susan L. Morris-Natschke, Hang Ma, Zhihong Liu, Navindra P. See-ram, Jun Xu, Kuo-Hsiung Lee, Qiong Gu* Euphomilones A and B, ent-rosane diterpenoids with 7/5/6 and 5/7/6 skeletons from Euphorbia milii. Org Lett, 2016, 18, 6132-6135.
10. Xiang-Kun Luo,# Jie Cai,# Zhi-Yong Yin, Pan Luo, Chan-Juan Li, Hang Ma, Navindra P. Seeram, Qiong Gu,* Jun Xu. Fluvirosaones A and B, two indolizidine alkaloids with a pentacyclic skeleton from Flueggea virosa. Org Lett, 2018, 20, 991-994.

*以上信息由高级会员个人更新和维护。