陈兰美

男， 广东医科大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

工作经历：
(1) 2020.01至现在, 广东医科大学, 药学院, 教授
(2) 2019-8至2020-8, Murdoch University, Centre for Molecular Medicine&Innovative Therapeutics, Visiting Fellow
(3) 2014.01至2020.03, 广东医科大学, 药学院, 副教授
(4) 2009.03至2013.12, 广东医科大学, 药学院, 讲师
(5) 2008.07至2009.01, 广东医科大学, 药学院, 助教

学习教育经历：
(1) 2003.09 至 2008-07, 中山大学, 化学生物学, 博士（硕博联读）
(2) 1999-09 至 2003-07, 信阳师范大学, 化学教育, 学士

研究领域和兴趣

生物无机化学，药物化学

主要业绩

主要从事具有靶向功能的天然产物小分子及其金属配合物的设计、合成及其抗肿瘤和抗菌研究。2015年广东省高等院校优秀青年教师培养对象，广东省高等学校“千百十人才培养工程”校级培养对象，广东省自然科学基金评审专家及Journal of Medicinal Chemistry, Chemical Engineering Journal, Advanced Science, Theranostics，European Journal of Medicinal Chemistry等杂志审稿人。先后主持国家自然科学青年基金，广东省自然科学基金，广东省优秀青年教师培养项目，广东省卫生厅及中药局等课题。以第一或通讯作者在国际知名SCI期刊上发表高水平论文38篇，H-index: 31，其中近五年来发表18篇。申请国家发明专利11项，已授权9项。

代表成果

[1] Xufeng Zhu1, Jinjun Chen1, Binhua Wu, Yating Huang, Yan Zou, Chunmei Liang, Yingnian Lu*, Hui Luo, Lanmei Chen*, Jincan Chen*, Polyvalent copper oxide nanozymes: Co-delivery of ROS and NO for inducing cuproptosis-like bacterial death against MRSA infections, Chemical Engineering Journal, 2024, 499, 156507.
[2] Jincan Chen1, Qian Wu1, Shenting Zhang, Jie Gao, Wenzhu Yu, Tianling Hu, Jiale Zhu, Miao Guo, Xufeng Zhu*, Lanmei Chen*, The efficient screening of avermectin B1a aptamer and colorimetric detection of its regulation of Ru NPs activity, Microchemical Journal, 2024, 206, 111429.
[3] Xufeng Zhu1, Chunmei Liang1, Jinjun Chen, Jie Gao, Weigang Chen, Qianqian Ouyang, Lianxiang Luo, Zunnan Huang, Hui Luo, Lanmei Chen*, Jincan Chen*, Phase separation of extracellular polymeric substances induced by bacteria responsive Nano-Antibiotics for drug-resistant bacterial infection management, Chemical Engineering Journal, 2024, 481, 148136.
[4] Lanmei Chen, Hong Tang, Tianling Hu, Jie Wang, Qianqian Ouyang, Xufeng Zhu*,Rui Wang, Wenyong Huang, Zunnan Huang*, Jincan Chen*, Three Ru(II) complexes modulate the antioxidant transcription factor Nrf2 to overcome cisplatin resistance, Journal of Inorganic Biochemistry, 2024, 259, 112666.
[5] Xufeng Zhu#, Qiang Sun#, Xinhua Guo, Chunmei Liang, Yao Zhang, Wenyong Huang, Wenliang Pei, Zunnan Huang*, Lanmei Chen*, Jincan Chen*, Cyclometalated ruthenium (II) complexes induced HeLa cell apoptosis through intracellular reductive injury, Journal of Inorganic Biochemistry, 2023, 112333.
[6] Weigang Chen, Xianhong Cai, Qiang Sun, Xinhua Guo, Chunmei Liang, Hong Tang,3 Heming Huang, Hui Luo, Lanmei Chen*, Jincan Chen*, Design and synthesis of aptamer-cyclometalated iridium(III) complex conjugate targeting cancer cells, European Journal of Medicinal Chemistry, 2022, 236, 114335.
[7] Lanmei Chen, Jie Wang, Xianhong Cai, Suxiang Chen, Jingjing Zhang, Baojun Li, Weigang Chen, Xinhua Guo, Hui Luo*, Jincan Chen*, Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway, Bioorganic Chemistry, 2022, 119, 105516.
[8] Jincan Chen, Yuanyuan Deng, Jie Wang, Suxiang Chen, Fa Peng, Xuerong He, Meijun Liu, Hui Luo*, Jingjing Zhang*, Lanmei Chen*, Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling, Journal of Biological Inorganic Chemistry, 2021, 26, 793–808.
[9] Tao Wang#, Lanmei Chen#, Arpitha Chikkanna, Suxiang Chen, Isabell Brusius, Nabayet Sbuh, Rakesh N. Veedu*, Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis, Theranostics, 2021, 11, 5174-5196
[10] 陈兰美，陈锦灿，吴谦，朱旭峰，张沈婷，郭淼，一种阿维菌素B1a适配体及其筛选方法和应用，中国，发明专利，专利号：ZL 2024 1 0158148.1，申请日：2024.02.04，授权日：2025.01.24。

*以上信息由高级会员个人更新和维护。