盛翔

男， 中国科学院天津工业生物技术研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

2005.09 - 2009.06 长春理工大学，化学与环境工程学院，化学工程与工艺，工学学士
2009.09 - 2014.06山东大学，化学与化工学院，化学（理论与计算化学），理学博士
2014.08 - 2018.12瑞典斯德哥尔摩大学，博士后
2019.01 - 2020.11瑞典斯德哥尔摩大学，研究科学家
2021.02–至今 中国科学院天津工业生物技术研究所，研究员

研究领域和兴趣

酶的计算模拟与理性设计

主要业绩

研究团队主要采用物理原理和人工智能融合的计算模拟方法研究生物酶体系中物质转化的化学基本原理、蛋白结构的动态变化规律以及新酶工业属性的调控机制，基于结构与功能信息，建立人工酶理性设计新方法，指导实现高效人工酶的精准智能创制。目前已解析数十种具有工业应用价值的酶体系的催化机制，阐明了调控其活性和选择性的关键因素，获得了多个高性能生物催化剂，并基于此设计和构建了多种药物和大宗化学品中间体的酶法合成路线。自2021年独立开展工作，作为第一/通讯（含共同）在Angew. Chem. Int. Ed. (3)、Nat. Commun. (2)、ACS Catal. (4)、ACS Cent. Sci.、Chem Catal、Acc. Chem. Res.等期刊发表论文30篇，申请中国发明专利8项；以项目负责人身份主持国家重点研发计划青年科学家项目、国家自然科学基金青年基金等国家和省部级项目4项，以课题/子课题负责人参与中国科学院C类先导专项、中国科学院稳定支持基础研究领域青年团队计划等。

代表成果

1. Fuqiang Chen, Chenghua Zhang, Shiqing Zhang, Wuyuan Zhang, Hao Su*, Xiang Sheng* Computational Modeling of the Enzymatic Achmatowicz Rearrangement by Heme-Dependent Chloroperoxidase: Reaction Mechanism, Enantiopreference, Regioselectivity, and Substrate Specificity. J. Chem. Inf. Model., 2025, 65, 1928-1939. https://doi.org/10.1021/acs.jcim.4c01658
2. Shiqing Zhang, Chenghua Zhang, Aijing Guo, Baoyan Liu, Hao Su*, Xiang Sheng* Computational Mechanistic Investigation of the Kinetic Resolution of α-Methyl-phenylacetaldehyde by Norcoclaurine Synthase. Commun. Chem., 2024, 7, 64. https://doi.org/10.1038/s42004-024-01146-x
3. Yuqiu Lan, Chenghua Zhang, Chunping Tang, Yang Ye, Rui Zhang, Xiang Sheng*, Cangsong Liao* Semirational Protein Engineering of a Decarboxylative Aldolase for Regiodivergent and Stereodivergent Synthesis of Cyclic Imino Acids. Angewandte Chemie International Edition, 2025, Accepted, e202500080. https://doi.org/10.1002/anie.202500080
4. Huanhuan Li, Yawen Huang, Fuqiang Chen, Zhigang Zeng, Frank Hollmann, Xin Wu, Xiyang Zhang, Peigao Duan*, Hao Su, Jianjun Shi, Xiang Sheng*, Wuyuan Zhang* Unspecific Peroxygenase Enabled Formation of Azoxy Compounds. Nat. Commun., 2024, 15, 8312. https://doi.org/10.1038/s41467-024-52648-0
5. Rui Zhang*, Chenghua Zhang, Jiamu Tan, Yifan He, Dan Zhuo, Jingxuan Zhang, Zhenzhen Luo, Qiaoqiao Li, Jiaying Yao, Changqiang Ke, Chunping Tang, Yang Ye, Shijun He, Xiang Sheng*, Cangsong Liao* Enzymatic Synthesis of Noncanonical α‐Amino Acids Containing γ‐Tertiary Alcohols. Angew. Chem. Int. Ed., 2024, 63, e202318550. https://doi.org/10.1002/anie.202318550
6. Xiaofeng Han, Fuqiang Chen, Huanhuan Li, Ran Ge, Qianqian Shen, Peigao Duan, Xiang Sheng*, Wuyuan Zhang* Reaction engineering blocks ether cleavage for synthesizing chiral cyclic hemiacetals catalyzed by unspecific peroxygenase. Nat. Commun., 2024, 15, 1235. https://doi.org/10.1038/s41467-024-45545-z
7. Zhiwei Deng, Hao Su, Xiaodong Hou, Huibin Xu, Zhenbo Yuan, Xiang Sheng*, Yijian Rao* Mechanistic Investigation on C–C Bond Cleavage of Anthraquinone Catalyzed by an Atypical Nonheme Iron-Dependent Dioxygenase BTG13. ACS Catal., 2024, 14, 797-811. https://doi.org/10.1021/acscatal.3c04053
8. Libo Zhang, Shiqing Zhang, Lijing Liao, Huanying Tang, Wenli Wang, Fucheng Yin, Liangliang Han, Kejin Zhu, Yushi Liu, Dingqiao Xu, Xiaobing Wang, Minjian Qin, Yibei Xiao*, Xiang Sheng*, Yucheng Zhao* Discovery, Structure, and Mechanism of the (R, S)-Norcoclaurine Synthase for the Chiral Synthesis of Benzylisoquinoline Alkaloids. ACS Catal., 2023, 13, 15164-15174. https://doi.org/10.1021/acscatal.3c03296
9. Xiang Sheng*, Fahmi Himo* The Quantum Chemical Cluster Approach in Biocatalysis. Acc. Chem. Res. 2023, 56, 938-947. https://doi.org/10.1021/acs.accounts.2c00795
10. Xuanzhong Liu, Zhenbo Yuan, Hao Su, Xiaodong Hou, Zhiwei Deng, Huibin Xu, Baodang Guo, Dejing Yin, Xiang Sheng*, Yijian Rao* Molecular Basis of the Unusual Seven-Membered Methylenedioxy Bridge Formation Catalyzed by Fe(II)/α-KG-Dependent Oxygenase CTB9. ACS Catal., 2022, 12, 3689-3699. https://doi.org/10.1021/acscatal.1c04627

*以上信息由高级会员个人更新和维护。