张传瑞

男， 中国科学院上海药物研究所/中科环渤海（烟台）药物高等研究院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999.09-2003.07 北京师范大学化学学院，应用化学，学士
2003.09-2008.07 中国科学院上海药物研究所，药物化学，博士
2008.07-2010.10 中国科学院上海药物研究所，助理研究员
2010.10-2011.01 中国科学院上海药物研究所，副研究员
2011.01-2012.01 美国亚利桑那大学，博士后
2012.01-2015.12 美国密歇根州立大学，博士后
2016.07-2022.12 重庆大学药学院，研究员
2022.12-至今 中国科学院上海药物研究所，研究员

研究领域和兴趣

天然药物、天然产物化学生物学、中药现代化

主要业绩

长期从事天然药物与中药现代化研究，专注于传统药用植物及药食两用植物中的药效物质基础、作用靶点及相关药理机制，同时开展天然来源的新药研发与中药现代化相关工作。
迄今，已对60余种药用植物开展了系统性的“资源挖掘-活性发现-机制研究”工作，共分离鉴定出2000余个单体化合物，其中新化合物700余个，涵盖18种新颖骨架60余个化合物。通过系统的药理筛选和构效关系研究，获得100余个具有抗肿瘤、抗炎、抗乙肝病毒等生物活性的化合物，并遴选出6个具有开发前景的先导分子。在此基础上，阐明了多种药用植物或药食两用植物的药效物质基础与作用机制。累计发表SCI论文70余篇，申请发明专利3项。主持国家自然科学基金面上项目、重点项目子课题等10余项。作为核心成员曾获上海市自然科学一等奖、中国药学会科学技术奖二等奖等重要奖项。

代表成果

1. Yu Liu, Wei Li, Yu Su, Li Rao, Qian He, Yun-Xia You, Chuan-Rui Zhang*, Dimeric alkenyl α-pyrones from Cryptocarya calcicola with their cytotoxicity, Phytochemistry, 243 (2026), 114724, https://doi.org/10.1016/j.phytochem.2025.114724;
2. Li Rao, Yu Su, Qian He, Jia Ye, Yu Liu, Yue Fan, Feng Hu, Zhen Zhou, Li-She Gan, Yonghui Zhang*, Chuan-Rui Zhang*, Geranylated or prenylated flavonoids from Cajanus volubilis, Chinese Journal of Natural Medicines, 21 (2023), 292−297, https://doi.org/10.1016/S1875-5364(23)60437-6;
3. Qian He, Simin Li, Yue Fan, Yu Liu, Yu Su, Zhen Zhou, Yi-Nan Zhang, Guo-Li Li*, Li Rao*, Chuan-Rui Zhang*, Complex flavanones from Cryptocarya metcalfiana and structural revision of oboflavanone A, Journal of Natural Products, 85 (2022), 1617−1625, https://doi.org/10.1021/acs.jnatprod.2c00279;
4. Yu Liu, Yun-Xia You, Li Rao, Qian He, Yu Su, Yue Fan, Yizhou Li, You-Kai Xu, Chuan-Rui Zhang*, Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity, Chinese Journal of Natural Medicines, 20 (2022), 139−147, https://doi.org/10.1016/S1875-5364(21)60112-7;
5. Qian He, Yue Fan, Yu Liu, Li Rao, Yun-Xia You, Yu Su, Zhen Zhou, You-Kai Xu, Chuan-Rui Zhang*, Cryptoyunnanones A‒H, complex flavanones from Cryptocarya yunnanensis, Journal of Natural Products, 84 (2021), 2209−2216, https://doi.org/10.1021/acs.jnatprod.1c00287;
6. Li Rao, Yao Li, Qian He, Yu Liu, Yu Su, Yun-Xia You, Yue Fan, Bin Lin, Yi-Nan Zhang, Chuan-Rui Zhang*, Iridoid constituents of Viburnum brachybotryum, Journal of Natural Products, 84 (2021), 1915−1923, https://doi.org/10.1021/acs.jnatprod.1c00042;
7. Li Rao, Yun-Xia You, Yu Su, Yue Fan, Yu Liu, Qian He, Yi Chen, Jie Meng, Lin Hu, Yizhou Li, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*, Lignans and neolignans with antioxidant and human cancer cell proliferation inhibitory activities from Cinnamomum bejolghota confirm its functional food property, Journal of Agricultural and Food Chemistry, 68 (2020), 8825−8835, https://doi.org/10.1021/acs.jafc.0c02885;
8. Wei Li, Li Rao, Yu Liu, Qian He, Yue Fan, Yun-Xia You, Yu Su, Feng Hu, You-Kai Xu, Bin Lin, Sheng Yin, Chuan-Rui Zhang*, (±)-Meliviticines A and B: rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity, Bioorganic Chemistry, 90 (2019), 103099, https://doi.org/10.1016/j.bioorg.2019.103099;
9. Chuan-Rui Zhang, Wajid Khan, Jehan Bakht, Muraleedharan G. Nair*, New antiinflammatory sucrose esters in the natural sticky coating of tomatillo (Physalis philadelphica), an important culinary fruit, Food Chemistry, 196 (2016), 726−732, https://doi.org/10.1016/j.foodchem.2015.10.007;
10. Chuan-Rui Zhang, Amila A. Dissanayake, Kudret Kevseroğlu, Muraleedharan G. Nair*, Evaluation of coriander spice as a functional food by using in vitro bioassays, Food Chemistry, 167 (2015), 24−29, https://doi.org/10.1016/j.foodchem.2014.06.120

*以上信息由高级会员个人更新和维护。