徐允河

男， 中国科学技术大学化学与材料科学学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999.09-2003.07 本科，化学，青岛大学
2003.09-2006.07 硕士，无机化学，南开大学
2006.09-2010.09 博士，有机化学，新加坡南洋理工大学
2010.09-2012.02 研究助理/博士后，新加坡南洋理工大学
2012.02-2020.12 副教授，中国科学技术大学
2021.01-----至今 特任教授/ 教授，中国科学技术大学

研究领域和兴趣

1）有机硅化合物合成方法及应用研究 2）新型金属有机试剂制备、合成及应用研究 3）活性农药分子设计与合成研究

主要业绩

围绕"烯烃立体选择性合成"这一核心科学问题，创新性地提出并发展了两类催化策略：1）铜催化C-Si键构筑策略，通过开发硅自由基加成、铜硅中间体介导的转化及硅氢化等新型反应模式，建立了烯基有机硅的立体可控合成新方法；2）过渡金属催化C-H活化策略，设计发展了分子内/分子间烯烃氧化交叉偶联新反应，实现了不饱和C-C键的精准修饰。这些系统性工作突破了传统烯烃合成中对多取代烯烃立体构型难以调控的瓶颈，为烯烃的立体选择性功能化提供了全新研究范式。

代表成果

1) Copper-catalyzed Intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes
Xiao-Yan Zhu, Wenyu Gao, Jin-Lin Xu, Zi-Lu Wang, Jin-Bo Zhao, Yun-He Xu*
Nat. Commun. 2025, 16, 378.

2) Regiodivergent Hydrosilylation of Polar Enynes to Synthesize Site-Specific Silyl-Substituted Dienes
Zi-Lu Wang, Ying Wang, Yu-Chen Sun, Jin-Bo Zhao and Yun-He Xu*
Angew. Chem. Int. Ed. 2024, 63, e202405791.

3) Regio- and enantioselective CuH-catalyzed 1,2- and 1,4-hydrosilylation of 1,3-enynes
Zi-Lu Wang, Qi Li, Meng-Wei Yang, Zhao-Xin Song, Zhen-Yu Xiao, Wei-Wei Ma, Jin-Bo Zhao and Yun-He Xu*
Nat. Commun. 2023, 14, 5048.

4) Copper-Catalyzed Regiodivergent and Enantioselective Hydrosilylation of Allenes
Jian-Lin Xu, Zhe-Yuan Xu, Zi-Lu Wang, Wei-Wei Ma, Xin-Yue Sun, Yao Fu*, Yun-He Xu*
J. Am. Chem. Soc. 2022, 144, 5535-5542.

5) Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes
Zheng-Li Liu, Chao Yang, Qi-Yan Xue, Meng Zhao, Cui-Cui Shan, Yun-He Xu*, Teck-Peng Loh
Angew.Chem. Int. Ed. 2019, 58, 16538–16542.

6) Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes
Bing Jiang, Meng Zhao, Shu-Sen Li, Yun-He Xu,* Teck-Peng Loh*
Angew.Chem. Int. Ed. 2018, 57, 5555 –5559.

7) Chelation versus Non-Chelation Control in the Stereoselective Alkenyl sp2 C-H Bond Finctionalization Reaction
Qiu-Ju Liang, Chao Yang, Fei-Fan Meng, Bing Jiang, Yun-He Xu,* Teck-Peng Loh*
Angew.Chem. Int.Ed. 2017, 56, 5091 –5095.

8) Pd-Catalyzed Intramolecular C-N Bond Cleavage, 1,4-Migration, sp(3) C-H Activation, and Heck Reaction: Four Controllable Diverse Pathways Depending on the Judicious Choice of the Base and Ligand
Min Wang, Xiang Zhang, Yu-Xuan Zhuang, Yun-He Xu,* Teck-Peng Loh*
J. Am. Chem. Soc. 2015, 137, 1341-1347.

9) Stereo- and Chemoselective Cross-Coupling between Two Electron-Deficient Acrylates: An Efficient Route to (Z, E)-Muconate Derivatives
Xu-Hong Hu, Jian Zhang, Xiao-Fei Yang, Yun-He Xu,* Teck-Peng Loh*
J. Am. Chem. Soc. 2015, 137, 3169-3172.

10) Synthesis of Highly Substituted Racemic and Enantioenriched Allenylsilanes via
Copper-Catalyzed Hydrosilylation of (Z)‑2-Alken-4-ynoates with Silylboronate
Min Wang, Zheng-Li Liu, Xiang Zhang, Pan-Pan Tian, Yun-He Xu,* Teck-Peng Loh*
J. Am. Chem. Soc. 2015, 137, 14830–14833.

*以上信息由高级会员个人更新和维护。