钱宇

男， 中山大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2003 - 2007，大连理工大学，制药工程专业，学士, 导师：孟庆伟
2007 - 2013，华东师范大学，有机化学专业，博士，导师：胡文浩
2011 - 2013，美国马里兰大学，化学与生物化学系，联合培养博士研究生&访问学者，导师：Michael P. Doyle
2013 - 2016，上海药明康德新药研发有限公司， 国际新药研发部项目组长
2016 - 2017，华东师范大学，化学与分子工程学院，副研究员
2017 - 2025，中山大学，药学院，副教授
2025- 至今， 中山大学，药学院，教授

研究领域和兴趣

高效多组分合成新技术及在抗感染与抗肿瘤药物开发中的应用

主要业绩

中山大学“百人计划”二期引进人才，广东省珠江人才创新团队核心成员，担任广东省化学会制药工程专业委员会常务委员、广东省药理学会海洋药物药理专业委员会委员。主要从事功能型金属卡宾类中间体参与的多组分反应研究，致力于发展高效、高选择性的多官能团化反应新策略。开创性提出“金属卡拜等价物—叶立德—新金属卡宾—叶立德—亲电捕捉”的级联转化新路径，突破了传统有机合成依赖分步构建碳碳键、碳杂原子键的固有模式。该路径通过精准调控金属卡宾中间体的反应活性，实现了多组分的高效协同转化，建立了普适性的分子成键新方法，为复杂功能分子的精准构筑提供了原创性技术支撑。相关成果在药物分子设计、功能材料开发等领域展现出重要应用前景。在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Nat. Commun.、Cancer Discov.、Chem. Sci.、Sci. China Chem.、J. Med. Chem.、Org. Lett. 等国际权威期刊发表SCI论文50余篇，获授权发明专利10余项（含PCT专利2项）。主持（或参与）国家自然科学基金、国家重点研发计划、科技部新药创制重大专项子课题、广东省自然科学基金、广东省珠江人才创新团队项目、广东省重点领域研发计划重点项目等多项国家级及省部级科研项目。

代表成果

[1] Xiaoyan Yang, Xiaoyu Zhou, Wenhao Hu*, Yu Qian*, “Asymmetric multi-component trifunctionalization reactions with α-Halo Rh-carbenes”, Nat. Commun., 2025, DOI: 10.1038/s41467-025-56446-0.
[2] Taoda Shi,*, Yukai Li, Jiying Yang, Weining Weng, Mengchu Zhang, Jirong Shu, Yu Qian,* Tianyuan Zhang, Wenhao Hu*, “Multicatalysis-Enabled Multicomponent Reactions Generate a PTP1B Inhibitor” ACS Cent. Sci., 2025, DOI:10.1021/ acscentsci.5c00041.
[3] Mengchu Zhang, Xiaoyan Yang, Xiang Fu, Xiaoyu Zhou, Yu Qian*, Wenhao Hu*, “Chemo- and diastereoselective four-component reactions with Rh carbynoids”, Green Synthesis and Catalysis, 2024, DOI: 10.1016/j.gresc.2024.10.006
[4] Pei Li, Maoqing Shi, Kaixin Yang, Tongfei Jing, Zhenghui Kang,* Wenhao Hu, Yu Qian*, “Diastereoselective Synthesis of 4‑Hydroxy-2-quinolinones via Formal [2 + 4] Cycloaddition Reactions Using α‑Diazo Pyrazoleamides as C2 Synthons”, Org. Lett. 2024, DOI: 10.1021/acs.orglett.4c01956.
[5] Yu Qian*, Jie Tang, Xiaoyu Zhou, Jian Luo, Xiaoyan Yang, Zhuofeng Ke*, and Wenhao Hu*, “Enantioselective Multifunctionalization with Rh Carbynoids”, J. Am. Chem. Soc. 2023, DOI: 10.1021/jacs.3c10460
[6] Mengchu Zhang, Tianyuan Zhang, Sifan Yu, Huang Qiu, Abdulla Yusuf, Xinfang Xu, Yu Qian*, Wenhao Hu*, “Construction of 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters via ternary catalysis”, Chem. Sci., 2023, DOI: 10.1039/d3sc03452f.
[7] Aimin Xu, Xiaoyu Zhou, Rimei Zheng, Zhijing Zhang, Xinru Yin, Kemiao Hong, Zhuofeng Ke*, Yu Qian*, Wenhao Hu*, “Chiral rhodium(II)-catalyzed asymmetric aldol-type interception of an oxonium ylide to assemble chiral 2,3-dihydropyrans”, Sci. China Chem. 2022, DOI: 10.1007/s11426-022-1275-9.
[8] Liu Hu, Xing Cai, Suzhen Dong, Yongjia Zhen, Jidi Hu, Shenjun Wang, Jingwen Jiang, Jiawu Huang, Yuqiao Han, Yu Qian*, Yanqiu Yuan*, Wenhao Hu, “Synthesis and Anticancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors” J. Med. Chem. 2020, DOI: 10.1021/acs.jmedchem.0c00079.
[9] Xichen Xu#, Yu Qian#, Peter Y. Zavalij, Michael P. Doyle*, “Selective catalyst-dependent competitive 1,2-C→C, -O→C and -N→C migrations from β-methylene-β-silyloxy-β-amido-α-diazoacetates”, J. Am. Chem. Soc. 2013, DOI: 10.1021/ja311392m.
[10] Yu Qian, Xinfang Xu, Xiaochen Wang, Peter J. Zavalij, Wenhao Hu, Michael P. Doyle*, “Rhodium(II)- and Copper(II)-Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways”, Angew. Chem. Int. Ed. 2012, DOI: 10.1002/ange.201202525.

*以上信息由高级会员个人更新和维护。